The physiological characteristics of zebra fish (Danio rerio) based on metabolism and behavior: A new method for the online assessment of cadmium stress

Qi, Luhuizi; Ma, Jingchun; Song, Jie; Li, Shangge; Cui, Xiaoru; Peng, Xiao-Fang; Wang, Weiliang; Ren, Zongming; Han, Mei; Zhang, Ying

doi:10.1016/j.chemosphere.2017.06.044

Cited by 30 publications

(6 citation statements)

References 44 publications

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“…After absorption, Cd is known to interfere with the biological roles of several essential ions, such as calcium, zinc, and magnesium, among others, and to interact with several biological targets resulting in a wide range of toxic effects [7,11,90,91], the most part of them are partially unrevealed. Some of the effects that have been described in fish exposed to Cd, such as histological alterations in several organs [21], disruption of ion balance [92], changes in the expression of genes related with stress responses [87], cytotoxicity [93], among others [16,17,18,94] may have also contributed to the reduction of the predatory performance found in M-est juveniles exposed to Cd alone. Although the inhibitory effect of Cd on AChE activity of several species is well known [95,96], the mechanisms involved are very complex and are not completely understood even in mammals where they have been intensively studied [e.g., 91,97,98].…”

Section: Resultsmentioning

confidence: 99%

Neurotoxicity, Behavior, and Lethal Effects of Cadmium, Microplastics, and Their Mixtures on Pomatoschistus microps Juveniles from Two Wild Populations Exposed under Laboratory Conditions―Implications to Environmental and Human Risk Assessment

Miranda

Vieira

Guilhermino

2019

IJERPH

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Microplastics (MPs) were found to modulate the toxicity of other pollutants but the knowledge on the topic is still limited. The goals of this study were to investigate the short-term toxicity of cadmium (Cd) to wild Pomatochistus microps juveniles, the potential modulation of acute Cd toxicity by 1–5 µm polyethylene MPs in this species, and possible differences of sensitivity to Cd and MPs-Cd mixtures between juveniles from two distinct wild populations. Juveniles were collected in the estuaries of Minho (M-est) and Lima (L-est) Rivers (NW Portugal). One 96 h bioassay with M-est juveniles and another one with L-est juveniles were carried out in laboratory conditions. Each bioassay had 12 treatments: control, 5 Cd concentrations, 1 MPs concentration, and 5 MPs-Cd mixtures. No significant differences in Cd-induced mortality between juveniles from distinct estuaries or between juveniles exposed to Cd alone and those exposed to MPs-Cd mixtures were found. The total 96h LC10 and LC50 of Cd alone were 2 mg/L (95% CI: 0–4 mg/L) and 8 mg/L (95% CI: 2–17 mg/L), respectively. Cd alone significantly decreased the post-exposure predatory performance (PEPP) of M-est (≥6 mg/L) and L-est juveniles (≥3 mg/L), and acetylcholinesterase (AChE) activity of M-est juveniles (13 mg/L). MPs alone (0.14 mg/L) significantly reduced the PEPP and AChE activity of L-est juveniles but not of M-est juveniles. MPs-Cd mixtures (3–13 mg/L of Cd + 0.14 mg/L of MPs) significantly inhibited the PEPP of juveniles from both estuaries and AChE of L-est estuary juveniles but not of M-est juveniles. Evidences of toxicological interactions, namely antagonism, between MPs and Cd were found. Overall, the results indicate that MPs modulated the sub-lethal toxic effects of Cd in wild P. microps juveniles, especially neurotoxicity. Moreover, the environmental conditions of the natural habitats to which juveniles were exposed during pre-developmental phases influence the sub-lethal toxicity of Cd, MPs, and their mixtures. The implications to environmental and human risk assessment are discussed and further research is needed.

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Section: Resultsmentioning

confidence: 99%

Neurotoxicity, Behavior, and Lethal Effects of Cadmium, Microplastics, and Their Mixtures on Pomatoschistus microps Juveniles from Two Wild Populations Exposed under Laboratory Conditions―Implications to Environmental and Human Risk Assessment

Miranda

Vieira

Guilhermino

2019

IJERPH

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“…With frog tadpoles, swimming performance has been shown to be a good indicator of environmental contamination (Semlitsch et al ; Bridges ; Denoёl et al ). Cameras to track organisms’ positions in 3 dimensions ( x , y , and z coordinates) and to analyze swimming behavior (Kang et al ), as well as online monitoring systems that include metabolism and behavior (Qi et al ), have also been developed and applied as tools to help in assessing the toxicity potential of contaminants. Reviews by Melvin and Wilson () and Parker () discuss the use of behavior in ecotoxicology in detail.…”

Section: Spatial Avoidance and Habitat Preference Versus Behavioral Ementioning

confidence: 99%

Spatial avoidance as a response to contamination by aquatic organisms in nonforced, multicompartmented exposure systems: A complementary approach to the behavioral response

Araújo¹,

Blasco²

2018

Enviro Toxic and Chemistry

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The idea that the hazard of contaminants is exclusively related to their toxic effects does not consider the fact that some organisms can avoid contamination, preventing toxicity. Although inferences about avoidance are made in most behavioral ecotoxicology studies, assessment of the real spatial displacement (organisms moving toward another habitat to escape contamination) is difficult due to the type of exposure (confined and mandatory) used in the bioassays: a forced exposure approach. A complementary approach using nonforced exposure systems to assess how contaminants affect the spatial distribution of organisms in a bicompartmented (toxic or nontoxic) environment has long been described. Recently, this nonforced approach has been developed to include a multi compartmented system in which different samples can be simultaneously tested. The aim of the present review was to describe the importance of the nonforced, multicompartmented exposure approach to simulate a gradient or patches of contamination, to describe the 2 main exposure systems, and to highlight the ecological relevance of including spatial avoidance and habitat preference in ecotoxicological studies. The multicompartmentalization of the system makes it possible to simulate more complex scenarios and therefore include new ecological concepts in bioassays. We also contrasted spatial avoidance in the nonforced exposure systems with the behavioral endpoints measured under other exposure systems. Finally, we showed that the nonforced, multicompartmented exposure approach makes it possible 1) to improve environmental risk assessments by adding the dispersion pattern of organisms in a multihabitat scenario, and 2) to integrate ecological concepts such as recolonization of recovering habitats, loss of habitat connectivity, habitat fragmentation, and contamination-driven metapopulation, which have received limited attention in ecotoxicological studies. Environ Toxicol Chem 2019;38:312-320. C 2018 SETAC

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“…Metals such as Cd affect gills by changing their morphology, which causes imbalanced respiration and osmoregulation (Evans 1987). When fish are exposed to sublethal Cd levels, this can negatively affect their life history (Cazan and Klerks 2015), physiology (Pereira et al 2016), and behavior (Qi et al 2017). However, fish can partly protect themselves against the damaging effects of metal exposure by metallothionein (MT) induction in the liver and kidneys (Carpene et al 1994).…”

Section: Introductionmentioning

confidence: 99%

Combined effects of cadmium exposure and temperature on the annual killifish (Nothobranchius furzeri)

Philippe

Hautekiet

Grégoir

et al. 2018

Enviro Toxic and Chemistry

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Freshwater organisms are increasingly exposed to combinations of stressors. However, because it is time-consuming and costly, research on the interaction of stressors, such as compound toxicity and global warming on vertebrates, is scarce. Studies on multigenerational effects of these combined stressors are almost nonexistent. In the present study, we tested the combined effects of 4 °C warming and cadmium (Cd) exposure on life-history traits, biomarkers, bioaccumulation, and multigenerational tolerance in the turquoise killifish, Nothobranchius furzeri. The extremely short life cycle of this vertebrate model allows for assessment of sublethal and multigenerational effects within 4 mo. The applied Cd concentrations had only limited effects on the measured endpoints, which suggests that N. furzeri is more resistant to Cd than fathead minnow and rainbow trout. In contrast, the temperature increase of 4 °C was stressful: it delayed female maturation and lowered adult mass and fecundity. Finally, indications of synergistic effects were found on peak fecundity and embryonic survival. Overall, these results indicate the importance of studying chronic and multigenerational effects of combined stressors. Environ Toxicol Chem 2018;37:2361-2371. © 2018 SETAC.

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The physiological characteristics of zebra fish (Danio rerio) based on metabolism and behavior: A new method for the online assessment of cadmium stress

Cited by 30 publications

References 44 publications

Neurotoxicity, Behavior, and Lethal Effects of Cadmium, Microplastics, and Their Mixtures on Pomatoschistus microps Juveniles from Two Wild Populations Exposed under Laboratory Conditions―Implications to Environmental and Human Risk Assessment

Neurotoxicity, Behavior, and Lethal Effects of Cadmium, Microplastics, and Their Mixtures on Pomatoschistus microps Juveniles from Two Wild Populations Exposed under Laboratory Conditions―Implications to Environmental and Human Risk Assessment

Spatial avoidance as a response to contamination by aquatic organisms in nonforced, multicompartmented exposure systems: A complementary approach to the behavioral response

Combined effects of cadmium exposure and temperature on the annual killifish (Nothobranchius furzeri)

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