The physiological expression of scavenger receptor SR-B1 in canine endometrial and placental epithelial cells and its potential involvement in pathogenesis of pyometra

Gabriel, Cordula; Becher-Deichsel, Anja; Hlavatý, Juraj; Mair, Georg; Walter, Ingrid

doi:10.1016/j.theriogenology.2016.01.021

Cited by 15 publications

(18 citation statements)

References 43 publications

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“…During luteal phase of estrous cycle blood progesterone level increases which in turn leads to increased secretions from endometrial glands, increase proliferation of endometrium, reduced myometrial contraction and closure of cervix (Hardie, 1995) that favours occurrence of disease. Factors associated with bacteria as well as their receptor expression may lead to enhance bacterial attachment to endometrium (Gabriel et al, 2016). Wijewardana et al (2015) described negative correlation between progesterone on maturation of antigen presenting dendritic cells which may lead to reduction of cell mediated immunity (CMI).…”

Section: Pathogenesismentioning

confidence: 99%

Canine Pyometra: Current Perspectives on Causes and Management – A Review

Kumar

Saxena²

2018

IJVSBT

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Canine pyometra is a pathological condition of endometrium which results in accumulation of purulent semisolid substance in uterus. Canine pyometra is a sequlae of cystic endometrial hyperplacia (CEH) which results from hormonal imbalance. Despite of enormous veterinary medical research and development, still its main aspect of etio-pathology is not fully known. Canine pyometra is mostly associated with other similar uterine pathological conditions, i.e., hydrometra, mucometra and chronic endomertitis.

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Section: Pathogenesismentioning

confidence: 99%

Canine Pyometra: Current Perspectives on Causes and Management – A Review

Kumar

Saxena²

2018

IJVSBT

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“…Importantly, the ability of E. coli bacteria to adhere to the uterine endometrium was shown to be increased under the influence of progesterone (Sandholm, Vasenius, & Kivistö, ), but this effect was not demonstrated in a later study (Krekeler, Lodge et al., ). Other factors and receptors expressed differently may also enhance bacterial attachment in pyometra (Leitner, Aurich, Galabova, Aurich, & Walter, ; Gabriel, Becher‐Deichsel, Hlavaty, Mair, & Walter, ). A negative effect by progesterone on the maturation of antigen‐presenting dendritic cells could also contribute to a diminished immune defence (Wijewardana et al., ).…”

Section: What Is New About the Pathogenesis And Hormones Versus Bactmentioning

confidence: 99%

Canine pyometra: What is new?

Hagman

2016

Reprod Domestic Animals

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“…104 All these features make EVs strong candidates as reporters and effectors of disease. In the context of CVD, EVs are involved in cell proliferation and differentiation, inflammation, stress response, angiogenesis, senescence, stem cell maintenance, tissue repair, and cardiovascular remodeling, [105][106][107][108][109][110] which are associated with many cardiovascular pathologies such as cardiac hypertrophy, heart failure, hypertension, atherogenesis, and diabetic cardiomyopathy. [111][112][113][114][115][116] Extracellular vesicle uptake and function EVs from donor cells can be taken up by recipient cells.…”

Section: Physiological and Pathological Functions Of Extracellular Vesiclesmentioning

confidence: 99%

Cardiovascular morbidities of obstructive sleep apnea and the role of circulating extracellular vesicles

Castro-Grattoni

Gozal

2019

Ther Adv Respir Dis

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Obstructive sleep apnea (OSA) is characterized by recurrent upper airway collapse during sleep resulting in impaired blood gas exchange, namely intermittent hypoxia (IH) and hypercapnia, fragmented sleep (SF), increased oxidative stress and systemic inflammation. Among a myriad of potential associated morbidities, OSA has been particularly implicated as mechanistically contributing to the prevalence and severity of cardiovascular diseases (CVD). However, the benefits of continuous positive airway pressure (CPAP), which is generally employed in OSA treatment, to either prevent or improve CVD outcomes remain unconvincing, suggesting that the pathophysiological mechanisms underlying the incremental CVD risk associated with OSA are not clearly understood. One of the challenges in development of non-invasive diagnostic assays is the ability to identify clinically and mechanistically relevant biomarkers. Circulating extracellular vesicles (EVs) and their cargos reflect underlying changes in cellular homeostasis and can provide insights into how cells and systems cope with physiological perturbations by virtue of the identity and abundance of miRNAs, mRNAs, proteins, and lipids that are packaged in the EVs under normal as well as diseased states, such as OSA. EVs can not only provide unique insights into coordinated cellular responses at the organ or systemic level, but can also serve as reporters of the effects of OSA in CVD, either by their properties enabling regeneration and repair of injured vascular cells or by damaging them. Here, we highlight recent progress in the pathological CVD consequences of OSA, and explore the putative roles of EVs in OSA-associated CVD, along with emerging diagnostic and therapeutic opportunities. The reviews of this paper are available via the supplemental material section.

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The physiological expression of scavenger receptor SR-B1 in canine endometrial and placental epithelial cells and its potential involvement in pathogenesis of pyometra

Cited by 15 publications

References 43 publications

Canine Pyometra: Current Perspectives on Causes and Management – A Review

Canine Pyometra: Current Perspectives on Causes and Management – A Review

Canine pyometra: What is new?

Cardiovascular morbidities of obstructive sleep apnea and the role of circulating extracellular vesicles

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