The physiological functions of lymphangiocrine signals

Liu, Cenxi; Li, Jin

doi:10.1016/j.tem.2023.03.004

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…While this review has focused on the discussion of angiocrine factors in embryonic development, it should also be noted that angiocrine and lymphangiocrine signaling has important roles in regeneration, homeostasis and disease, which have been explored in other recent reviews ( Rafii et al, 2016 ; Pasquier et al, 2020 ; Gomez-Salinero et al, 2021 ; Chen and Ding, 2022 ; Liu and Li, 2023 ). As the molecular mechanisms regulating embryonic development are often reinitiated in regeneration, and hijacked by disease, the knowledge garnered on angiocrine factors in embryonic development is likely to impact our understanding of angiocrine signals and their potential therapeutic applications in these fields.…”

Section: Discussionmentioning

confidence: 99%

Endothelial-derived angiocrine factors as instructors of embryonic development

Bishop

Schwarz

Wiszniak

2023

Front. Cell Dev. Biol.

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Blood vessels are well-known to play roles in organ development and repair, primarily owing to their fundamental function in delivering oxygen and nutrients to tissues to promote their growth and homeostasis. Endothelial cells however are not merely passive conduits for carrying blood. There is now evidence that endothelial cells of the vasculature actively regulate tissue-specific development, morphogenesis and organ function, as well as playing roles in disease and cancer. Angiocrine factors are growth factors, cytokines, signaling molecules or other regulators produced directly from endothelial cells to instruct a diverse range of signaling outcomes in the cellular microenvironment, and are critical mediators of the vascular control of organ function. The roles of angiocrine signaling are only beginning to be uncovered in diverse fields such as homeostasis, regeneration, organogenesis, stem-cell maintenance, cell differentiation and tumour growth. While in some cases the specific angiocrine factor involved in these processes has been identified, in many cases the molecular identity of the angiocrine factor(s) remain to be discovered, even though the importance of angiocrine signaling has been implicated. In this review, we will specifically focus on roles for endothelial-derived angiocrine signaling in instructing tissue morphogenesis and organogenesis during embryonic and perinatal development.

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Section: Discussionmentioning

confidence: 99%

Endothelial-derived angiocrine factors as instructors of embryonic development

Bishop

Schwarz

Wiszniak

2023

Front. Cell Dev. Biol.

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“…Furthermore, several other lymphangiogenic factors, such as collagen and calcium-binding EGF domain-containing protein (CCBE1), Semaphorins and Neuropilins, fibroblast growth factor-2 (FGF2), sphingosine 1-phosphate (S1P), bone morphogenetic protein-9 (BMP9) and activin-like kinase receptor type I (ALK1), Notch1 and Ephrin B2 are studied and reviewed thoroughly elsewhere ( 164 ). In addition to lymphangiogenic factors, lymphoangiocrine molecules, such as Reelin, that are secreted from the lymphatics during injury are reported to mediate the beneficial effects of lymphangiogenesis in a disease context, and these factors and associated pathways could be worthwhile to investigate as novel therapeutic targets ( 165 , 166 ).…”

Section: Therapeutic Targets and Opportunitiesmentioning

confidence: 99%

Targeting lymphatic function in cardiovascular-kidney-metabolic syndrome: preclinical methods to analyze lymphatic function and therapeutic opportunities

Fowler,

Song,

Tam

et al. 2024

Front. Cardiovasc. Med.

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The lymphatic vascular system spans nearly every organ in the body and serves as an important network that maintains fluid, metabolite, and immune cell homeostasis. Recently, there has been a growing interest in the role of lymphatic biology in chronic disorders outside the realm of lymphatic abnormalities, lymphedema, or oncology, such as cardiovascular-kidney-metabolic syndrome (CKM). We propose that enhancing lymphatic function pharmacologically may be a novel and effective way to improve quality of life in patients with CKM syndrome by engaging multiple pathologies at once throughout the body. Several promising therapeutic targets that enhance lymphatic function have already been reported and may have clinical benefit. However, much remains unclear of the discreet ways the lymphatic vasculature interacts with CKM pathogenesis, and translation of these therapeutic targets to clinical development is challenging. Thus, the field must improve characterization of lymphatic function in preclinical mouse models of CKM syndrome to better understand molecular mechanisms of disease and uncover effective therapies.

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“…With single cell RNA-seq analysis, we have determined that NTS was also produced specifically by the lymphatic endothelial cells (LECs) as an anti-thermogenic peptide in the brown adipose tissue (23) and a pro-lipid absorption peptide regulating the development of atherosclerosis in the intestine (24)(25)(26). Ntsr2, but not Ntsr1, is widely expressed in brown adipocytes, beige adipocytes and white adipocytes (27).…”

Section: Introductionmentioning

confidence: 99%

Neurotensin-Neurotensin Receptor 2 signaling in adipocytes regulates food intake through ceramide metabolism

Fu,

Yang,

Guo

et al. 2024

Preprint

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SUMMARYNeurotensin (NTS) is a secretory peptide produced by the lymphatic endothelial cells (LEC). Our previous study revealed that NTS suppressed the activity of brown adipose tissue via the interactions with NTSR2. In the current study, we found that the depletion ofNtsr2in the white adipocytes upregulated food intake, while the local treatment of NTS suppressed the food intake. Mechanistic study revealed that the suppression of NTS-NTSR2 signaling enhanced the phosphorylation of ceramide synthetase 2 (CerS2), increased the abundance of its products ceramide C20-C24 and downregulated the production of GDF15 in the white adipose tissues, which was responsible for the elevation of food intake. With four populations of different age and ethnic background, we discovered a potential causal and positive correlation between ceramide C20-24 and food intake in human. Our study identified that NTS-NTSR2 signaling can perform the neurological regulation via controlling the production of ceramide in the white adipocytes.

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The physiological functions of lymphangiocrine signals

Cited by 4 publications

References 11 publications

Endothelial-derived angiocrine factors as instructors of embryonic development

Endothelial-derived angiocrine factors as instructors of embryonic development

Targeting lymphatic function in cardiovascular-kidney-metabolic syndrome: preclinical methods to analyze lymphatic function and therapeutic opportunities

Neurotensin-Neurotensin Receptor 2 signaling in adipocytes regulates food intake through ceramide metabolism

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