The physiological role of histamine in the exocrine pancreas

Singh, Jaipaul; Pariente, José A.; Salido, Ginés M.

doi:10.1007/s000110050156

Cited by 20 publications

(15 citation statements)

References 62 publications

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“…231 In the human pancreas, histamine is more abundant in the head portion compared to the tail. Histamine immunoreactive mast cells are distributed throughout the pancreas in many species including humans, dogs, fox, sheep, pigs, cattle, and rats.…”

Section: Histaminementioning

confidence: 99%

“…231 In the human pancreas, histamine is more abundant in the head portion compared to the tail. 231,235 Histamine directly stimulated pancreatic enzyme secretion from pancreatic lobules in vitro from the rat, rabbit, and guinea pig. Due to its location around blood vessels and its known vasodilatory effects, it was postulated that histamine may play a role in mediating pancreatic blood flow, particularly in the microcirculation.…”

Section: Histaminementioning

confidence: 99%

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Regulation of Pancreatic Secretion

Liddle¹

2012

Physiology of the Gastrointestinal Tract

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Section: Histaminementioning

confidence: 99%

Section: Histaminementioning

confidence: 99%

Regulation of Pancreatic Secretion

Liddle¹

2012

Physiology of the Gastrointestinal Tract

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“…More recently, other substances including the islet hormones, vasoactive intestinal polypeptide (VIP), phorbol esters, nitric oxide, histamine and the growth hormones have been implicated in the regulation of exocrine pancreatic secretion (Pearson et al 1982;Singh, 1985a;Nishizuka, 1988;Owyang, 1993;Williams & Goldfine, 1993;Lajas et al 1996;Singh et al 1997). The different secretagogues exert their stimulatory effect via four functionally distinct signal transduction pathways.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Islet Hormones with Cholecystokinin Octapeptide‐Evoked Secretory Responses in the Isolated Pancreas of Normal and Diabetic Rats

Singh

Adeghate

Salido

et al. 1999

Experimental Physiology

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summaryThis study investigates the effects of the islet hormones, insulin (Ins), glucagon (Glu) and somatostatin (Som) with cholecystokinin octapeptide (CCK-8) on amylase secretion and intracellular free calcium concentration [Ca¥]é and their pattern of distribution in the isolated pancreas of normal and diabetic rats. Ins and Glu evoked small increases in amylase output from pancreatic segments compared with a much enhanced effect of CCK-8. In contrast, Som induced a biphasic response comprising an initial decrease followed by a secondary increase and this biphasic response may be dependent upon the concentration. Combining the islet hormones with CCK-8 resulted in marked potentiation in amylase output compared with either CCK-8 alone or the individual hormone. Genistein and tyrphostin A25, the tyrosine kinase inhibitors, evoked a small decrease in amylase output from pancreatic segments. They had no effect on the CCK-8-evoked secretory response but markedly inhibited the potentiation of the islet hormones with CCK-8. In pancreatic acini and acinar cells Ins, Glu and Som individually evoked small increases in amylase output compared with a much larger response with CCK-8. When the islet hormones were combined with CCK-8 there was no potentiation of amylase output. Similarly, when rats were rendered diabetic by prior treatment with streptozotocin Ins, Glu and Som failed to potentiate the secretory response of CCK-8. In fura_2-loaded pancreatic acinar cells Ins or Glu evoked small increases in [Ca¥]é compared with a much larger elevation with CCK-8. Ins, Glu and Som each enhanced the CCK-8-evoked [Ca¥]é. Genistein elicited a decrease in [Ca¥]é both in the absence and presence of the islet hormones. It also decreased the elevation in [Ca¥]é resulting from the combined presence of CCK-8 with either Ins or Glu but it had no effect on CCK-8 in combination with Som. In pancreatic acinar cells from diabetic rat Ins, Glu and Som had no detectable effect on CCK-8-evoked elevation in [Ca¥]é compared with the response obtained with CCK-8 alone. CCK-8-immunopositive cells were distributed around the walls of blood vessels, numerous Inspositive cells in the central and peripheral parts of the islets of Langerhans, Glu-immunoreactive cells in the periphery of islets and Som-positive cells in the outer part of the islets. During diabetes, the number of CCK-immunopositive cells remained unchanged whereas the number of Inspositive cells decreased coupled with an increase in the number of Glu-positive cells. The results indicate that both tyrosine kinase and cellular Ca¥ seem to be the intracellular mediators involved with the enhanced secretory responses obtained with a combination of the islet hormones with CCK-8. Moreover, the presence of viable pancreatic islets of Langerhans seems to be associated with the potentiation of the islet hormones with CCK-8.

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“…These results suggest that CCK is one, but not the exclusive, mediator of pancreatic secretion induced by beer. However, direct effects of beer on enzyme secretion has not been examined, and can not necessarily be inferred from infusion or injection studies because of potential interaction with enteropancreatic reflexes [6], other hormones [7–9] or regulators [9,10] in vivo .…”

Section: Resultsmentioning

confidence: 99%

Beer and its Non-Alcoholic Compounds: Role in Pancreatic Exocrine Secretion, Alcoholic Pancreatitis and Pancreatic Carcinoma

Gerloff

Singer

Feick

2010

IJERPH

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In this article we provide an overview of the newest data concerning the effect of non-alcoholic constituents of alcoholic beverages, especially of beer, on pancreatic secretion, and their possible role in alcoholic pancreatitis and pancreatic carcinoma. The data indicate that non-alcoholic constituents of beer stimulate pancreatic enzyme secretion in humans and rats, at least in part, by direct action on pancreatic acinar cells. Some non-alcoholic compounds of beer, such as quercetin, resveratrol, ellagic acid or catechins, have been shown to be protective against experimentally induced pancreatitis by inhibiting pancreatic secretion, stellate cell activation or by reducing oxidative stress. Quercetin, ellagic acid and resveratrol also show anti-carcinogenic potential in vitro and in vivo. However, beer contains many more non-alcoholic ingredients. Their relevance in beer-induced functional alterations of pancreatic cells leading to pancreatitis and pancreatic cancer in humans needs to be further evaluated.

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The physiological role of histamine in the exocrine pancreas

Cited by 20 publications

References 62 publications

Regulation of Pancreatic Secretion

Regulation of Pancreatic Secretion

Interaction of Islet Hormones with Cholecystokinin Octapeptide‐Evoked Secretory Responses in the Isolated Pancreas of Normal and Diabetic Rats

Beer and its Non-Alcoholic Compounds: Role in Pancreatic Exocrine Secretion, Alcoholic Pancreatitis and Pancreatic Carcinoma

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