The physiology of growth hormone and sport

Widdowson, W. Matthew; Healy, Marie-Louise; Sönksen, Peter H.; Gibney, James

doi:10.1016/j.ghir.2009.04.023

Cited by 52 publications

(41 citation statements)

References 162 publications

(182 reference statements)

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“…In acromegalic patients, excess GH does not result in increased muscle mass or strength (21)(22)(23), while the observed increase in muscle strength and endurance experienced by GHD patients following GH treatment appear to be a result of altered metabolic functions as well as a stimulation of protein synthesis, suppression of protein oxidation and increased muscle mass (24)(25)(26)(27). Taken together, it is currently not clear whether GH/IGF1 and skeletal muscle myofibrillar protein synthesis are positively correlated in man, but investigating both acromegalic and GHD patients offers a unique possibility to address this question.…”

Section: Introductionmentioning

confidence: 99%

GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients

Doessing¹,

Holm²,

Heinemeier³

et al. 2010

European Journal of Endocrinology

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Objective: Disproportionate growth of musculoskeletal tissue is a major cause of morbidity in both acromegalic (ACRO) and GH-deficient (GHD) patients. GH/IGF1 is likely to play an important role in the regulation of tendon and muscle collagen. We hypothesized that the local production of collagen is associated with the level of GH/IGF1. Design and methods: As primary outcomes, collagen mRNA expression and collagen protein fractional synthesis rate (FSR) were determined locally in skeletal muscle and tendon in nine ACRO and nine GHD patients. Moreover, muscle myofibrillar protein synthesis and tendon collagen morphology were determined. Results and conclusions: Muscle collagen I and III mRNA expression was higher in ACRO patients versus GHD patients (P!0.05), whereas collagen protein FSR did not differ significantly between ACRO and GHD patients in muscle (PZ0.21) and tendon (PZ0.15). IGF1Ea and IGF1Ec mRNA expression in muscle was higher in ACRO patients versus GHD patients (P!0.01). Muscle IGF1Ea mRNA expression correlated positively with collagen I mRNA expression (P!0.01). Tendon collagen fibrillar area tended to be higher in GHD patients relative to ACRO patients (PZ0.07). Thus, we observed a higher expression for collagen and IGF1 mRNA in local musculotendinous tissue in ACRO patients relative to GHD patients. Moreover, there was a tendency towards a higher collagen protein FSR and a smaller collagen fibril diameter in ACRO patients relative to GHD patients. The results indicate a collagenstimulating role of local IGF1 in human connective tissue and add to the understanding of musculoskeletal pathology in patients with either high or low GH/IGF1 axis activity.

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Section: Introductionmentioning

confidence: 99%

GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients

Doessing¹,

Holm²,

Heinemeier³

et al. 2010

European Journal of Endocrinology

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“…O GH, como o cortisol, também apresenta importante função no controle da glicemia ao promover elevação dos substratos que estimulam a gliconeogênese hepática 24 . Em nosso estudo podemos observar tal comportamento, as concentrações de GH elevaram na recuperação com pico em Rec.…”

Section: Discussionunclassified

Estudo do comportamento cortisol, gh e insulina apos uma sessao de exercicio resistido agudo

Silva

Souza

Tomaz

et al. 2014

Rev Bras Med Esporte

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RESUMOIntrodução: Muitos trabalhos têm estudado o comportamento hormonal nos exercício resistido, entretanto poucos relacionam os hormônios cortisol, GH e insulina. Objetivo: Estudar os ajustes das concentrações plasmáticas dos hormônios cortisol, GH e insulina em exercícios resistidos de mesma intensidade com relação à massas musculares distintas. Métodos: Dez voluntários, com 20,3 ± 4,2 anos, 74,1 ± 10,2 kg de peso, 177,2 ± 4,6 cm de estatura e 23,8 ± 3,2 kg/m 2 de IMC, realizaram uma sessão de leg press (LP) e supino reto (SR) com quatro séries com 10 repetições a 70% 1 RM com três minutos de intervalo. Foram coletadas amostras de sangue para dosagem das concentrações plasmáticas de cortisol, GH e insulina em repouso (Pré) e em 0' (Rec. 0'), 30' (Rec. 30') e 90' (Rec. 90') de recuperação. Resultados: As concentrações plasmáticas de cortisol foram significativamente reduzidas ao final da recuperação em LP (2,20±0,37 ng/dl para 1,33±0,38ng/dl) em relação à pré-dosagem. As concentrações de GH e insulina elevaram-se significativamente durante a recuperação. GH em LP foi significativamente maior em Rec. 0' (2,75±3,29 ng/ml para 9,60±5,32 ng/dl) do que em pré. A insulina elevou-se significativamente em Rec. 30' em LP (14,70±7,92 ulU/ml para 21,66 ± 8,61 ulU/ml) e em SR (6,17 ± 2,99 ulU/ml para 19,70 ± 13,8 ulU/ml) em relação à pré. As concentrações plasmáticas de insulina pré em LP foram significativamente superiores a SR (14,70 ulU/ml e 6,17 ± 2,99 ulU/ml). Conclusão: O exercício resistido promoveu diferentes ajustes nas concentrações hormonais de cortisol, GH e insulina durante o período de recuperação.Palavras-chave: exercício físico, cortisol, hormônio do crescimento, insulina. ABSTRACTIntroduction: Many works have studied the hormonal behavior in resistance exercise, however, few relate the cortisol, GH and insulin hormones. Objective: To study the adjustments of plasma concentrations of the cortisol, GH and insulin hormones in resisted exercises of the same relative intensity with different muscle musses. Methods: Ten volunteers, aged 20.3 ± 4.2 years, weight 74.1 ± 10.2 Kg, 177.2 ± 4.6 cm of stature and 23.8 ± 3.2 Kg/m

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“…In addition, it has been shown that regular exercise leads to an increase in GH secretion rate during 24 hours (9,17). Regarding the effect of physical activity on basic GH level, some researchers have found that moderate and submaximal aerobic and anaerobic exercises don't have any significant effect on the basic level of GH, but maximal anaerobic exercises cause a significant increase in GH secretion (10)(11)(12)(13)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

“…Detailed analysis of data demonstrated that GH basic level of all subjects increased symmetrically following maximal exercise. Increase in GH secretion leads to higher efficiency of the athletes particularly in long-term sports directly by raising oxygen transmission, fat oxidation and muscular potency and indirectly by changing body composition or increasing body temperature set (17).…”

Section: Discussionmentioning

confidence: 99%

Growth hormone and blood sugar changes after exercise under the maximum and maximum in adolescent athletes

Nikseresht¹,

Tazangi²,

Khoshnam³

2011

jjums

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Introduction:Growth hormone is a strong metabolic factor that facilitates growth and hypertrophy and increase transfer of amino acids into the cells. Exercise is a potent stimulant of growth hormone secretion. If it is regularly done, the rate of hormone secretion increases in 24 hours. In previous studies, the role of championship training has been little considered. So, given the importance of the abovementioned hormone in puberty period and the necessity of participation in the championship, this study aimed to investigate the relationship between physical activity in championship level and changes of this hormone. Material and Methods:12 male adolescent athletes Estahban were chosen as the subjects. Finally, eight of them (mean age= 14.44, height= 1.56 m and weight= 46.3 kg) participated in the study. Blood samples were collected before exercise, after 10 weeks of submaximal exercise, and at the end of 3 weeks of maximal exercise. ,. The samples were collected 12 hours after the last training. Results:The results indicated that submaximal exercise had no significant effect on baseline growth hormone and blood sugar (p=0.446, p=0.289). But maximal training caused a significant increase in the baseline growth hormone and blood sugar (p=0.048, p=0.045). Conclusion:According to the results, exercise intensity below the maximum for male adolescents has a significant impact on the amount of baseline growth hormone whereas maximal exercise increases the amount of baseline growth hormone significantly. Increased growth hormone leads to increased protein synthesis, increased bone, increased muscle size and improved athletic performance.

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The physiology of growth hormone and sport

Cited by 52 publications

References 162 publications

GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients

GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients

Estudo do comportamento cortisol, gh e insulina apos uma sessao de exercicio resistido agudo

Growth hormone and blood sugar changes after exercise under the maximum and maximum in adolescent athletes

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