The physiology of waterborne silver toxicity in freshwater rainbow trout (Oncorhynchus mykiss) 2. The effects of silver thiosulfate

Wood, Chris M.; Högstrand, Christer; Gálvez, Fernando; Munger, R. Stephen

doi:10.1016/0166-445x(96)00004-5

Cited by 61 publications

(62 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The model overpredicts gill Ag accumulation in juvenile rainbow trout in the first 5 h of exposure (maximum factor 4.8 deviation), but shows better predictions for longer exposure durations, that is, from 8 until 24 h of exposure (Figure 1a,d). Gill Ag accumulation is well predicted (within a factor of 2.3) in adult rainbow trout after 50 h exposure (McGeer & Wood 13 ), and after 6 days of exposure (Webb & Wood, 31 Wood et al 8 ). The model predicts the timecourse of NKA inhibition reasonably well for juvenile rainbow trout (Figure 1b,e).…”

Section: ■ Resultsmentioning

confidence: 95%

Toxicokinetic Toxicodynamic (TKTD) Modeling of Ag Toxicity in Freshwater Organisms: Whole-Body Sodium Loss Predicts Acute Mortality Across Aquatic Species

Veltman

Hendriks

Huijbregts

et al. 2014

Environ. Sci. Technol.

View full text Add to dashboard Cite

ToxicoKinetic ToxicoDynamic (TKTD) models are considered essential tools to further advance acute toxicity prediction of metals for a range of species and exposure conditions, but they are currently underutilized. We present a mechanistic TKTD model for acute toxicity prediction of silver (Ag) in freshwater organisms. In this new approach, we explicitly link relevant TKTD processes to species (physiological) characteristics, which facilitates model application to other untested freshwater organisms. The model quantifies the reduction in whole-body sodium concentration over time as a function of the target site inhibition over time, the target site density and the species-specific sodium turnover rate. Freshwater species are assumed to die instantly when they have lost a critical amount of their initial whole-body sodium concentration. Results show that mortality is significantly related to sodium loss (r(2) = 0.86) for various aquatic organisms and exposure durations. The model accurately predicts lethal effect concentrations for different freshwater organisms, including Daphnia magna, rainbow trout and juvenile crayfish, and is able to capture the observed size-specific variation of nearly 2 orders of magnitude in empirical LC50s.

show abstract

Section: ■ Resultsmentioning

confidence: 95%

Toxicokinetic Toxicodynamic (TKTD) Modeling of Ag Toxicity in Freshwater Organisms: Whole-Body Sodium Loss Predicts Acute Mortality Across Aquatic Species

Veltman

Hendriks

Huijbregts

et al. 2014

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…Therefore, the mechanism of cytotoxicity of NPs is complicated and the possibility of effects from metal ions has been proposed. Wood et al (1996) reported Ag + toxicity towards aquatic organisms such as fish is caused by the disturbance of ionic regulation. Silver ions were taken up into gill cells via proton-coupled Na + channels (Bury and Wood, 1999) and may then block the ion transporter Na + /K + ATPase.…”

Section: Discussionmentioning

confidence: 99%

A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells

Wang

Aker

Hwang

et al. 2011

Science of The Total Environment

160

View full text Add to dashboard Cite

Nanoparticles (NPs), including nano metal oxides, are being used in diverse applications such as medicine, clothing, cosmetics and food. In order to promote the safe development of nanotechnology, it is essential to assess the potential adverse health consequences associated with human exposure. The liver is a target site for NP toxicity, due to NP accumulation within it after ingestion, inhalation or absorption. The toxicity of nano-ZnO, TiO2, CuO and Co3O4 was investigated using a primary culture of channel catfish hepatocytes and human HepG2 cells as in vitro model systems for assessing the impact of metal oxide NPs on human and environmental health. Some mechanisms of nanotoxicity were determined by using phase contrast inverted microscopy, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays, reactive oxygen species (ROS) assays, and flow cytometric assays. Nano-CuO and ZnO showed significant toxicity in both HepG2 cells and catfish primary hepatocytes. The results demonstrate that HepG2 cells are more sensitive than catfish primary hepatocytes to the toxicity of metal oxide NPs. The overall ranking of the toxicity of metal oxides to the test cells is as follows: TiO2 < Co3O4< ZnO < CuO. The toxicity is due not only to ROS-induced cell death, but also damages to cell and mitochondrial membranes.

show abstract

“…6a). Regardless, these concentrations are remarkably high compared with those of other metals (e.g., Ag, Cd, Cu, and Zn), for which measured plasma metal concentrations on the order of 2 to 25 mol/L have been measured [22][23][24][25]. Pane et al [17] measured a plasma Ni concentration of 107 mol/L in a 99-h exposure to 11 mg/L of dissolved Ni, and they observed continually increasing Ni plasma over the time course of this exposure, with no indication of saturation.…”

Section: Chronic Toxicity Of Nickelmentioning

confidence: 97%

Acute and chronic toxicity of nickel to rainbow trout (Oncorhynchus mykiss)

Brix¹,

Keithly

DeForest

et al. 2004

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Of the fish species tested in chronic Ni exposures, rainbow trout (Oncorhynchus mykiss) is the most sensitive. To develop additional Ni toxicity data and to investigate the toxic mode of action for Ni, we conducted acute (96-h) and chronic (85-d early life-stage) flow-through studies using rainbow trout. In addition to standard toxicological endpoints, we investigated the effects of Ni on ionoregulatory physiology (Na, Ca, and Mg). The acute median lethal concentration for Ni was 20.8 mg/L, and the 24-h gill median lethal accumulation was 666 nmol/g wet weight. No effects on plasma Ca, Mg, or Na were observed during acute exposure. In the chronic study, no significant effects on embryo survival, swim-up, hatching, or fingerling survival or growth were observed at dissolved Ni concentrations up to 466 microg/L, the highest concentration tested. This concentration is considerably higher than the only other reported chronic no-observed-effect concentration (<33 microg/L) for rainbow trout. Accumulation of Ni in trout eggs indicates the chorion is only a partial barrier with 36%, 63%, and 1% of total accumulated Ni associated with the chorion, yolk, and embryo, respectively. Whole-egg ion concentrations were reduced by Ni exposure. However, most of this reduction occurred in the chorion rather than in the embryos, and no effects on hatching success or larval survival were observed as a result. Plasma ion concentrations measured in swim-up fingerlings at the end of the chronic-exposure period were not significantly reduced by exposure to Ni. Nickel accumulated on the gill in an exponential manner but plateaued in trout plasma at waterborne Ni concentrations of 118 microg/L or greater. Consistent with previous studies, Ni did not appear to disrupt ionoregulation in acute exposures of rainbow trout. Our results also suggest that Ni is not an ionoregulatory toxicant in long-term exposures, but the lack of effects in the highest Ni treatment precludes a definitive conclusion.

show abstract

The physiology of waterborne silver toxicity in freshwater rainbow trout (Oncorhynchus mykiss) 2. The effects of silver thiosulfate

Cited by 61 publications

References 20 publications

Toxicokinetic Toxicodynamic (TKTD) Modeling of Ag Toxicity in Freshwater Organisms: Whole-Body Sodium Loss Predicts Acute Mortality Across Aquatic Species

Toxicokinetic Toxicodynamic (TKTD) Modeling of Ag Toxicity in Freshwater Organisms: Whole-Body Sodium Loss Predicts Acute Mortality Across Aquatic Species

A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells

Acute and chronic toxicity of nickel to rainbow trout (Oncorhynchus mykiss)

Contact Info

Product

Resources

About