The phytochemical and pharmacological profile of taraxasterol

Jiao, Fengjuan; Tan, Zengyue; Zhou, Bojie; Meng, Lingyan; Shi, Xinyue

doi:10.3389/fphar.2022.927365

Cited by 19 publications

(6 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TAX could be isolated from many types of plants including Taraxacum o cinale F. H. Wigg 23,24 . In recent years, the anti-tumor function of TAX has gained increased attention.…”

Section: Discussionmentioning

confidence: 99%

“…TAX can be extracted from many types of plants and is one of the main active components of Taraxacum o cinale F. H. Wigg 23 . Previous studies have proved that TAX has anti-in ammatory, antioxidative and anti-carcinogenic properties 24 . TAX can inhibit tumor cells growth of many types of cancer including nasopharyngeal carcinoma, breast carcinoma, colon carcinoma, cervix carcinoma, ovary carcinoma and so on [25][26][27] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Taraxasterol suppresses the proliferation and tumor growth of prostate cancer cells through the FGFR2-PI3K/AKT signaling pathway

Yang

Xin

Yin

et al. 2023

Preprint

View full text Add to dashboard Cite

Prostate cancer (PCa)is prevalent among older men and difficult to survive after metastasis. It is urgent to find new drugs and treatments. Several studies show that taraxasterol (TAX) has important anti-inflammatory, anti-oxidative and anti-tumor effects. However, the function and mechanisms of TAX in PCa remain unclear. Here, we found that TAX could significantly suppress the viability and growth of PCa cells and down-regulate the expression of c-Myc and cyclin D1 in vitro. Mechanistically, PI3K/AKT signaling pathway was weakened and the expression of FGFR2 was reduced after TAX treatment in PCa cells. Moreover, TAX evidently inhibited the tumor growth in nude mice and the expression of c-Myc, cyclin D1, p-AKT and FGFR2 were down-regulated in xenograft tumor. These results indicate that TAX suppresses the proliferation of PCa cells via inhibiting the activation of PI3K/AKT signaling pathway and the expression of FGFR2, which means TAX may be a novel anti-tumor agent for PCa treatment.

show abstract

“…TAX could be isolated from many types of plants including Taraxacum o cinale F. H. Wigg 23,24 . In recent years, the anti-tumor function of TAX has gained increased attention.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Taraxasterol suppresses the proliferation and tumor growth of prostate cancer cells through the FGFR2-PI3K/AKT signaling pathway

Yang

Xin

Yin

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…TAX could be isolated from many types of plants including Taraxacum officinale Wigg 24 , 25 . In recent years, the anti-tumor function of TAX has gained increased attention.…”

Section: Discussionmentioning

confidence: 99%

“…TAX can be extracted from many types of plants and is one of the main active components of Taraxacum officinale Wigg 24 . Previous studies have proved that TAX has anti-inflammatory, anti-oxidative and anti-carcinogenic properties 25 . TAX can inhibit tumor cells growth of many types of cancer including nasopharyngeal carcinoma, breast carcinoma, colon carcinoma, cervix carcinoma, ovary carcinoma and so on 26 – 28 .…”

Section: Introductionmentioning

confidence: 99%

Taraxasterol suppresses the proliferation and tumor growth of androgen-independent prostate cancer cells through the FGFR2-PI3K/AKT signaling pathway

Yang,

Xin,

Yin

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Prostate cancer (PCa) is prevalent among older men and difficult to survive after metastasis. It is urgent to find new drugs and treatments. Several studies show that taraxasterol (TAX) has important anti-inflammatory, anti-oxidative and anti-tumor effects. However, the function and mechanisms of TAX in PCa remain unclear. Here, we found that TAX could significantly suppress the viability and growth of androgen-independent PCa cells and down-regulate the expression of c-Myc and cyclin D1 in vitro. Mechanistically, PI3K/AKT signaling pathway was weakened and the expression of FGFR2 was reduced after TAX treatment in androgen-independent PCa cells. Moreover, TAX evidently inhibited the tumor growth in nude mice and the expression of c-Myc, cyclin D1, p-AKT and FGFR2 were down-regulated in xenograft tumor. These results indicate that TAX suppresses the proliferation of androgen-independent PCa cells via inhibiting the activation of PI3K/AKT signaling pathway and the expression of FGFR2, which means TAX may be a novel anti-tumor agent for later PCa treatment.

show abstract

“…The triterpenoid taraxasterol is a bioactive compound widely recognized for its presence in several medicinal plants, presenting pharmacological properties, such as antiinflammatory, antioxidant, anticarcinogenic activities [26], and chemopreventive action [27]. The compound luteolin, a flavonoid found in several species of plants used in traditional medicine, exerts activities as an antioxidant, antiallergic [28], anti-inflammatory [29], anticarcinogenic agent [30,31] and others.…”

Section: Fig 3 Sars-cov-2 Proteins That Demonstrated High Levels Of I...mentioning

confidence: 99%

In Silico Study of Organic Compounds from Dipteryx odorata with SARS-COV-2 Targets by Molecular Docking and ADME-TOX Analysis

Souza,

Sousa

et al. 2024

JAMMR

View full text Add to dashboard Cite

Introduction: The new coronavirus SARS-CoV-2, identified in December 2019 as the cause of COVID-19, has triggered an outbreak of potentially fatal atypical pneumonia. The constant search for new molecules or strategies to combat this disease continues. Thus, the objective of this work was to evaluate, using in silico methods, the compounds present in Dipteryx odorata as inhibitors of crucial targets of SARS-COV-2. Methodology: The methodology included the selection of plant compounds from the Pubchem database and obtaining the structures of SARS-COV-2 proteins (6vxx, 6lu7, 1R42) from the Protein Data Bank (PDB). The molecular docking analysis was performed using the Autodock Tools 1.5.6 and Autodock Vina programs, LigPlus to obtain amino acids, and Chimera v.13.1 to generate 3D images. The absorption, distribution, metabolism, excretion and toxicity (ADME-TOX) properties of the most promising compounds were evaluated with the pkCSM tool. Results: In total, 672 molecular dockings were carried out, tested with 168 ligands, resulting in 17 compounds with binding energies lower than -7.9 kcal.mol-¹. A highlight was the exceptional interaction of the vouacapenic acid compound with the Spike protein, recording an energy of -9.9 kcal.mol-¹. The study revealed that compounds such as vouacapenic acid, taraxasterol and luteolin showed notable interactions with the Spike protein, in addition to positive results in the ADMET-TOX profile. Conclusion: These findings indicate the potential of these compounds and point to the need for in vivo and in vitro studies to validate their antiviral efficacy as therapeutic agents against SARS-COV-2.

show abstract

The phytochemical and pharmacological profile of taraxasterol

Cited by 19 publications

References 91 publications

Taraxasterol suppresses the proliferation and tumor growth of prostate cancer cells through the FGFR2-PI3K/AKT signaling pathway

Taraxasterol suppresses the proliferation and tumor growth of prostate cancer cells through the FGFR2-PI3K/AKT signaling pathway

Taraxasterol suppresses the proliferation and tumor growth of androgen-independent prostate cancer cells through the FGFR2-PI3K/AKT signaling pathway

In Silico Study of Organic Compounds from Dipteryx odorata with SARS-COV-2 Targets by Molecular Docking and ADME-TOX Analysis

Contact Info

Product

Resources

About