The Phytochemical Constituents and Pharmacological Activities of Annona atemoya: A Systematic Review

Abstract

Annona atemoya also known as the custard apple is a hybrid between two Annonaceae species: Cherimoya (Annona cherimola) and the sugar apple (Annona squamosa). It is widely cultivated in tropical and subtropical continents including north and south America, Asia, Africa and Australia. Despite becoming an increasingly important commercial fruit plant due to its’ creamy succulent flesh, compared to other Annonaceae species relatively few studies have investigated the phytochemistry and bioactivities of A. atemoya. Studies that evaluated A. atemoya extracts and its constituents were searched through the databases Scopus, Pubmed and Embase from inception to June 2020. Constituents of A. atemoya include alkaloids, flavonoids, terpenes and acetogenins. The results indicate that the constituents of A. atemoya possess cytotoxic, anti-angiogenic, hypolipidemic, antioxidant, anti-inflammatory and neuroprotective activities. However, many of these studies are currently limited in quality and further phytochemical and pharmacological studies are required.

Botanical, genetic, phytochemical and pharmaceutical aspects of Annona cherimola Mill

“…This effect was caused by the action of the epidermal growth factor receptor/G protein-coupled receptor kinase 2 pathway. These activities were even higher than other extracts from previously characterized medicinal plants (Kazman et al, 2020). These data showed that the extract of species of the family Annonaceae may be the basis of future drug development for neurological disorder treatment.…”

“…Experiments using antibody microarray analysis showed that epidermal growth factor receptor was induced in neuronal cells in mice. The technique of high-performance liquid chromatography showed that rutin is highly present in the extract of this Annona hybrid and together with isoquercitrin revealed inhibitory action on Aβ aggregation (Kazman et al, 2020). This evidence demonstrated that rutin is a bioactive compound against Alzheimer's disease.…”

Phytochemical analysis of Annona atemoya seed extract by HPLC and their ability to inhibit the growth of Agrobacterium tumefaciens

“…The presence of acetogenin, alkaloids, essential oils, phenolic compounds, cyclic peptides, amino acids, dyes, and vitamins has also been reported from the extract of different Annona plant parts (Bhardwaj et al 2020). In addition, alkaloids and flavonoids are found in the seeds of A. atemoya and A. squamosa (Al Kazman et al 2020;Kumar et al 2021).…”

“…Many tropical and subtropical continents, including southern and northern America, Asia, Africa, and Australia, as well as Spain, are home to A. atemoya cultivation. A. atemoya is a cross between the Cherimoya (Annona squamosa) (Li et al 2019; Kazman et al 2020). A. atemoya is short-branched with low, drooping branches and grows to a height of around 7.5 to 10 m. The leaves of A. atemoya, which average 15 cm in length, are alternate, leathery, deciduous, and less hairy than those of the parent cheimola.…”

“…The fruits have a nice flavor, with white flesh and smooth, brown-to-black seeds. The pulp can be easily separated from the white flesh (Kazman et al 2020;Kupe et al 2021). There are known uses for several Annona species, including Annona muricata, in conventional and alternative medicine.…”