The phytochemical, proximate, pharmacological, GC-MS analysis of Cyperus esculentus (Tiger nut): A fully validated approach in health, food and nutrition

Nwosu, Laurine Chikodiri; Edo, Great Iruoghene; Özgör, Erkay

doi:10.1016/j.fbio.2022.101551

Cited by 76 publications

(30 citation statements)

References 31 publications

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“…In general, fatty acids and their esters as a single molecular entity or in combination with other molecules have been shown to exhibit a variety of biological and pharmacological activities, which include antiasthma, antidiuretic, hepatoprotective, antieczemic, antimicrobial, antihistaminic, antiarthritic and cytotoxic activity in various murine and human cancer cell lines. [11][12][13][14][15] For example, octanoic acid has been shown to exhibit anticancer property on human colorectal, skin and mammary gland cancer cells in the MTT assay and reduced cancer cell viability by 70-90%. 16 Additionally, the serum level of octanoic acid has been shown to serve as a biomarker or predictor for the prognosis of advanced colorectal cancer.…”

Section: The Gc-ms Phytochemical Analysis Of Fractions 1 and 2 From T...mentioning

confidence: 99%

“…22 Additionally, n-hexadecanoic acid exhibited antioxidant, antifungal, hypocholesterolemic and anti-inflammatory activities 14,23 and it has been used as an emollient and 5α-reductase inhibitor. 15,23 n-Hexadecanoic acid together with other compounds exhibited antibacterial activity against a panel of bacterial strains. 14 n-Heptadecanoic acid inhibited cell proliferation significantly and promoted apoptosis in PC9 and PC9/GR cells.…”

Section: The Gc-ms Phytochemical Analysis Of Fractions 1 and 2 From T...mentioning

confidence: 99%

“…Compound 3 was obtained as colourless crystals. Its electron impact ionisation (EI, 70 eV) mass spectrum showed molecular ion peak at m/z 256 (95) and other fragment ions at m/z 227 (24), 213 (70), 185 (38), 171 (35), 143 (15), 129 (74), 97 (48), 73 (100), 55 (90), 43 (86). The molecular formula of 3 was determined to be C 16 H 32 O 2 from its molecular ion peak.…”

Section: Fine Chemical Engineering Volume 3 Issue 2|2022| 127mentioning

confidence: 99%

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Phytochemical Analysis and Cytotoxic Activity of Hexane Extract from Lasiosphaera nipponica

Pillai

2022

Fine Chemical Engineering

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Lasiosphaera nipponica finds therapeutic applications as a hemostatic in the traditional Japanese and Chinese medicines. The present study aimed to analyse the phytochemical compositions of two fractions from a hexane extract of L. nipponica by GC-MS analysis and evaluate the cytotoxic activity of these two fractions and a pure compound viz. ergosterol peroxide by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT assay). A hexane extract from L. nipponica was obtained by maceration technique and silica gel column chromatography of this hexane extract led to obtain two fractions and three pure compounds. The two fractions were analysed for phytochemical compositions by GC-MS and the presence of fatty acids, esters of fatty acids and ethyl 9-oxononanoate were identified. Additionally, these two fractions were evaluated for cytotoxic activity in P388, HL60, MCF7, HepG2 and J82 cancer cell lines in culture by MTT assay. Fraction 1 showed good activity in P388 and HL60 cancer cell lines with IC50 values of 9.8 and 18.2 μg/mL, respectively. Fraction 2 also showed good activity in P388 and HL60 cancer cell lines with IC50 values of 19.4 and 16.2 μg/mL, respectively. However, these two fractions did not show any appreciable activity in MCF7, HepG2 and J82 cancer cell lines. The three pure compounds were characterised as n-hexadecanoic acid, n-octadecanoic acid and ergosterol peroxide by spectroscopic means. Of these three pure compounds, only ergosterol peroxide was evaluated for cytotoxic activity in HL60, HepG2 and J82 cancer cell lines. Ergosterol peroxide showed an IC50 value of 82.2 μM (35.1 μg/mL) in HL60 cancer cell lines but it did not show any appreciable activity in HepG2 and J82 cancer cell lines. n-Hexadecanoic acid and n-octadecanoic acid were not evaluated for cytotoxic activity since they obtained in small quantity. From this study, we concluded that the fractions from a hexane extract of L. nipponica have therapeutically important phytochemicals and they exhibited promising cytotoxic activity in P388 and HL60 cancer cell lines. Further studies on L. nipponica are required to explore its therapeutic applications.

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Section: The Gc-ms Phytochemical Analysis Of Fractions 1 and 2 From T...mentioning

confidence: 99%

Section: The Gc-ms Phytochemical Analysis Of Fractions 1 and 2 From T...mentioning

confidence: 99%

Section: Fine Chemical Engineering Volume 3 Issue 2|2022| 127mentioning

confidence: 99%

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Phytochemical Analysis and Cytotoxic Activity of Hexane Extract from Lasiosphaera nipponica

Pillai

2022

Fine Chemical Engineering

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“…3 In recent years, honey has been used as a source of energy-giving food and a major ingredient in cereal-based food for flavoring, coloring and sweetening. [4][5][6] The physicochemical analysis parameters are based on the nectar`s (type and region), soil composition, climatic conditions, processing, storage and transportat 7 . The adulteration of honey can be measured from the physicochemical analysis results.…”

Section: Introductionmentioning

confidence: 99%

“…It has been primarily used for wound remedies and intestinal infections. 6,16 Unfortunately, no physicochemical analysis has been applied in investigating its quality. This research aims to investigate and evaluate the physicochemical characteristic of different honey produced in Delta State, Nigeria, to confirm its economic and nutritional quality compared to the international standard.…”

Section: Introductionmentioning

confidence: 99%

The physicochemical analysis and health benefits of fresh and branded honey produced in delta state, Nigeria

Edo¹,

Onoharigho²,

Emakpor³

et al. 2022

JAPLR

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This research is aimed to investigate and evaluate the physicochemical characteristic of different honey produced in Delta State, Nigeria, to confirm its economical and nutritional quality in comparison with the international standard. The quality of fresh and branded honey samples produced in Delta State was assessed using physicochemical and mineral analysis. Eight fresh honey (FHs) samples and eight branded honey (BHs) samples were collected from the Autonomous Province of Delta State, Nigeria. The tested parameters were pH, free acidity, electrical conductivity, color intensity, moisture, ash, proline, diastase, HMF, invertase, glucose, fructose, sucrose, lipid and mineral content. A qualitative test (Fiehe, Lund and Lugol) was performed to test the purity of honey. Both honey samples displayed good physicochemical properties. The concentration level of sugars was higher in the branded honey in comparison to fresh honey samples. The physicochemical parameters of fresh and branded honey were in concordance with the international standard.

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A review on the biological and bioactive components of Cyperus esculentus L.: insight on food, health and nutrition

Edo,

Samuel,

Nwachukwu

et al. 2024

J Sci Food Agric

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Tiger nut (Cyperus esculentus L.) is a small, tuberous root vegetable that has gained increasing attention in recent years due to its potential health benefits. This review article provides an elaborate overview of tiger nut, including its botany, historical uses, nutritional composition, potential health benefits and traditional medicinal uses. This review article comprehensively discusses the nutritional profile of tiger nut, providing a detailed understanding of its nutrient content. Furthermore, the potential health benefits of tiger nut are thoroughly reviewed, including its effects on digestive health, cardiovascular health, blood sugar control, immune function and other potential therapeutic uses. Scientific articles used for this review were retrieved from ScienceDirect, Google Scholar, PubMed and SciELO databases. Only articles published between 1997 and 2022 were used for research. This review contributes to a better understanding of tiger nut and its prospective uses in functional foods and medicine by combining the available scientific material. © 2024 Society of Chemical Industry.

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The phytochemical, proximate, pharmacological, GC-MS analysis of Cyperus esculentus (Tiger nut): A fully validated approach in health, food and nutrition

Cited by 76 publications

References 31 publications

Phytochemical Analysis and Cytotoxic Activity of Hexane Extract from Lasiosphaera nipponica

Phytochemical Analysis and Cytotoxic Activity of Hexane Extract from Lasiosphaera nipponica

The physicochemical analysis and health benefits of fresh and branded honey produced in delta state, Nigeria

A review on the biological and bioactive components of Cyperus esculentus L.: insight on food, health and nutrition

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