The phytoestrogen ferutinin improves sexual behavior in ovariectomized rats

Zavatti, Manuela; Benelli, Augusta; Montanari, C.; Zanoli, Paola

doi:10.1016/j.phymed.2008.11.008

Cited by 19 publications

(9 citation statements)

References 43 publications

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“…The partner preference test, performed according to Ågmo et al. 18 with minor modifications, as described previously, 19 was used to evaluate sexual motivation under no‐contact conditions. The apparatus consisted of an open field arena (100 × 50 × 40 cm high) with two round cages made of wire meshing (16 cm diameter, 40 cm high) positioned diagonally at the opposite corners of the arena.…”

Section: Methodsmentioning

confidence: 99%

Effects of the cannabinoid antagonist SR 141716 on sexual and motor behaviour in receptive female rats

Zavatti

Carnevale

Benelli

et al. 2011

Clinical and Experimental Pharmacology and Physiology

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1. The aim of the present study was to investigate the effect of the cannabinoid antagonist/inverse agonist SR 141716 (SR) on the receptive behaviour and sexual motivation of female rats. 2. Partner preference, receptivity and proceptivity were evaluated in ovariectomized female rats primed with oestrogen and progesterone and administered SR (1 or 2.5 mg/kg, i.p.) 20 min prior to testing. 3. In the partner preference test, a reduced interest in both stimulus animals (a sexually active male and an ovariectomized hormone-primed female) was detected in rats treated with SR at both doses, but no effect on preference score was observed. In the receptivity test, pronounced reductions in lordosis quotient, lordosis rating and in the percentage of receptive females were found in SR-treated rats compared with control rats. Proceptive behaviours were not significantly affected by either dose of SR. 4. In addition, we explored the behavioural effects induced by SR in female rats using the open field test. Only at the higher dose (i.e. 2.5 mg/kg) did SR markedly increased grooming and scratching behaviour. 5. The results demonstrate the ability of SR to reduce female sexual receptivity, but not sexual motivation. The reduction does not seem strictly related to the motor alterations induced by the cannabinoid antagonist.

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Section: Methodsmentioning

confidence: 99%

Effects of the cannabinoid antagonist SR 141716 on sexual and motor behaviour in receptive female rats

Zavatti

Carnevale

Benelli

et al. 2011

Clinical and Experimental Pharmacology and Physiology

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“…Previous phytochemical investigation on F. hermoni , root and seed, revealed the presence of various sesquiterpenes, mainly of the daucane type (Abourashed et al , ; Galal, ; Galal et al , ; Diab et al , ; Lhuillier et al , ; Nazari and Iranshahi, ). Extensive research was done to study the hormonal activity of the isolated sesquiterpenes from F. hermonis and recently herbal products containing F. hermonis extract have been sold in the dietary supplement market claiming a sexual function enhancement (Abourashed et al , ; Appendino et al , ; Greige‐Gerges et al , ; Khleifat et al , ; Homady et al , ; Ikeda et al , ; Zanoli et al , ; Zavatti et al , ). Different activities were also reported including antiinflammatory (Geroushi et al , ), cytotoxic (Auzi et al , ; Elouzi et al , ) and other activities (Abdallah et al , ; Severini et al , ; Macho et al , ; Zamaraeva et al , ; Palumbo et al , ; Ferretti et al , ; Hanafi et al , ).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Antioxidant Daucane Sesquiterpenes from Ferula hermonis Boiss

Ibraheim

Abdel‐Mageed

Dai

et al. 2011

Phytotherapy Research

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Seventeen daucane sesquiterpenoid esters, including a new one (4), were isolated from the root of Ferula hermonis Boiss. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidence and correlated with known compounds. The relative stereochemistry of the new compound was determined using 2D NOESY and the most stable and the lowest energy conformation was determined using molecular modelling. The antimicrobial activity was evaluated by determination of MIC using the broth microdilution method against six bacterial strains and one fungal strain (Pseudomonas aeruginosa PAO1, Escherichia coli, Bacillus subtilis ATCC6633, Mycobacterium bovis BCG Pasteur, Mycobacterium tuberculosis H37Rv, Staphylococcus aureus ATCC6538 and Candida albicans SC5314). There was a significant indication that compounds 15, 16, 17 demonstrated potent activity against Gram +ve (S. aureus, B. subtilis), as well as Mycobacterium strains M. bovis BCG and M. tuberculosis H37Rv. None of the isolated compounds exhibited a significant antifungal activity. In the antioxidant study using the DPPH assay method, the highest radical scavenging activity was observed for compounds 15, 16, 17.

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“…Ferutinin, the main component, showed a binding affinity for both estrogen receptors (ERa and ERb) equivalent to about one-tenth of the binding affinity of estradiol and with a potent estrogenic effect [143]. The ethanolic extract must be considered an active phytoestro-gen. Ovariectomized nonestrogen-primed rats did not display lordosis during sexual behavior assessment due to hormone deficiency [144]. This deficit was associated with the inability to perform paced mating behavior and a lack of preference for a sexually active male [145,146].…”

Section: Ferula Hermonismentioning

confidence: 94%

“…The ethanolic extract must be considered an active phytoestrogen. Ovariectomized nonestrogen‐primed rats did not display lordosis during sexual behavior assessment due to hormone deficiency [144]. This deficit was associated with the inability to perform paced mating behavior and a lack of preference for a sexually active male [145,146].…”

Section: Estrogenic Effectsmentioning

confidence: 97%

Medicinal Plants as Alternative Treatments for Female Sexual Dysfunction: Utopian Vision or Possible Treatment in Climacteric Women?

Mazaro-Costa

Andersen

Hachul

et al. 2010

The Journal of Sexual Medicine

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Introduction Female sexual dysfunction (FSD) is a complex and multifactorial condition. An increased incidence of FSD is especially associated with the decline of estrogen. Thus, menopause is a critical phase for FSD complaints. In this context, medicinal plants may be a therapeutic option. Aim To identify and describe the popular and clinical uses of medicinal plants for FSD treatment in climacteric women. We highlighted the majority of the plants commonly involved with the female reproductive system including: Angelica sinensis, Cimicifuga racemosa, Ferula hermonis, Ginkgo biloba, Humulus lupulus, Lepidium meyenii, Tribulus terrestris, Trifolium pratense, and Vitex agnus-castus. Methods This study is a narrative review of studies of plants that are possible alternative treatments for FSD. The species described have clinical and popular uses in different cultures as well as medical indications for female reproductive disturbances, mainly in climacteric women. We have also analyzed the evidence level of clinical studies. Main Outcome Measures The main outcome assessed is the efficacy of plants in improving the symptoms of FSD. Results There is little evidence from the literature to recommend the use of medicinal plants when treating FSD. The majority of studies with a strong level of evidence are associated with the treatment of the vasomotor symptoms of menopause. Ferula hermonis, Angelica sinensis, and Gingko biloba may be suggested for arousal disorder studies. Cimicifuga racemosa, Trifolium pratense, and Vitex agnus-castus may be recommended for several FSD. Humulus lupulus and Tribulus terrestris may help with desire disorder studies. Lepidium meyenii should be studied further. Conclusions Studies of these plants indicate that they may be useful as a possible alternative and/or complementary approach for studies aimed at the treatment of FSD. At this time, however, this review cannot recommend a plant that has a strong enough level of evidence for treatment of FSD. Thus, there is a need for clinical (double-blinded and randomized) studies to evaluate the efficacy and safety of several plants that can exert a positive effect on the management of FSD.

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The phytoestrogen ferutinin improves sexual behavior in ovariectomized rats

Cited by 19 publications

References 43 publications

Effects of the cannabinoid antagonist SR 141716 on sexual and motor behaviour in receptive female rats

Effects of the cannabinoid antagonist SR 141716 on sexual and motor behaviour in receptive female rats

Antimicrobial Antioxidant Daucane Sesquiterpenes from Ferula hermonis Boiss

Medicinal Plants as Alternative Treatments for Female Sexual Dysfunction: Utopian Vision or Possible Treatment in Climacteric Women?

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