The PI3K/Akt and NF-κB signaling pathways are involved in the protective effects of<i>Lithocarpus polystachyus</i>(sweet tea) on APAP-induced oxidative stress injury in mice

Yang, Jiayu; Zhong, Yu-te; Hao, Wei-Nan; Liu, Xiang-xiang; Shen, Qiong; Liu, Hui; Ren, Shengxiang; Wang, Zi; Li, Wei; Zhao, Lichun

doi:10.1039/d0ra00020e

Cited by 2 publications

(3 citation statements)

References 46 publications

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“…TLB and cisplatin were dissolved in 0.9% sterile saline. The dosage determination of TLB and cisplatin was based on our preliminary experiments and other previous studies. ,, …”

Section: Methodsmentioning

confidence: 99%

“…The dosage determination of TLB and cisplatin was based on our preliminary experiments and other previous studies. 1 , 20 , 21 …”

Section: Methodsmentioning

confidence: 99%

“…The dosage determination of TLB and cisplatin was based on our preliminary experiments and other previous studies. 1,20,21 The mice of cisplatin + TLB 50 and cisplatin + TLB 100 groups were administered intragastrically with TLB (50 and 100 mg/kg per day) for 10 consecutive days, respectively. The mice of the control group were administered intragastrically with sterile saline during this period.…”

Section: Chemical Compounds and Reagentsmentioning

confidence: 99%

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Trilobatin, an Active Dihydrochalcone from Lithocarpus polystachyus, Prevents Cisplatin-Induced Nephrotoxicity via Mitogen-Activated Protein Kinase Pathway-Mediated Apoptosis in Mice

Duan

et al. 2022

ACS Omega

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Although naturally occurring flavonoids have shown beneficial effects on the side effects caused by cisplatin, there are few reports on the protective effect of dihydrochalcone on the cisplatin-induced toxicity. Trilobatin (TLB), as the major sweetener and active ingredient in Lithocarpus polystachyus Rehd, is a dihydrochalcone-like compound that can be present in concentrations of up to 10% or more in tender leaves. Herein, a cisplatininduced acute kidney injury (AKI) model was established to investigate the protective effect and mechanism of TLB against the cisplatin-induced nephrotoxicity in mice. The results showed that TLB significantly reversed the inhibition of CRE, BUN, and MDA levels compared with the cisplatin group. Furthermore, TLB treatment (50 and 100 mg/kg) for 10 days significantly alleviated cisplatin-induced renal pathological changes. TUNEL staining showed that TLB administration can effectively improve the occurrence of apoptosis of renal tissue cells caused by cisplatin exposure. Importantly, western blot analysis verified that TLB alleviated cisplatin-induced nephrotoxicity by regulating the AKT/MAPK signaling pathway and apoptosis. In summary, our findings showed clearly that TLB has a significant preventive effect on cisplatin-induced AKI.

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“…TLB and cisplatin were dissolved in 0.9% sterile saline. The dosage determination of TLB and cisplatin was based on our preliminary experiments and other previous studies. ,, …”

Section: Methodsmentioning

confidence: 99%

“…The dosage determination of TLB and cisplatin was based on our preliminary experiments and other previous studies. 1 , 20 , 21 …”

Section: Methodsmentioning

confidence: 99%

Section: Chemical Compounds and Reagentsmentioning

confidence: 99%

See 1 more Smart Citation

Trilobatin, an Active Dihydrochalcone from Lithocarpus polystachyus, Prevents Cisplatin-Induced Nephrotoxicity via Mitogen-Activated Protein Kinase Pathway-Mediated Apoptosis in Mice

Duan

et al. 2022

ACS Omega

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Dual anti-inflammatory effects of curcumin and berberine on acetaminophen-induced liver injury in mice by inhibiting NF-κB activation via PI3K/AKT and PPARγ signaling pathways

Zhai,

Wang,

Wan

et al. 2024

Biochemical and Biophysical Research Communications

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The PI3K/Akt and NF-κB signaling pathways are involved in the protective effects ofLithocarpus polystachyus(sweet tea) on APAP-induced oxidative stress injury in mice

Abstract: Acetaminophen (APAP)-induced acute liver injury (ALI) is a health issue that has gradually attracted attention, and is often regarded as a model of drug-induced hepatotoxicity.

Cited by 2 publications

References 46 publications

Trilobatin, an Active Dihydrochalcone from Lithocarpus polystachyus, Prevents Cisplatin-Induced Nephrotoxicity via Mitogen-Activated Protein Kinase Pathway-Mediated Apoptosis in Mice

Trilobatin, an Active Dihydrochalcone from Lithocarpus polystachyus, Prevents Cisplatin-Induced Nephrotoxicity via Mitogen-Activated Protein Kinase Pathway-Mediated Apoptosis in Mice

Dual anti-inflammatory effects of curcumin and berberine on acetaminophen-induced liver injury in mice by inhibiting NF-κB activation via PI3K/AKT and PPARγ signaling pathways

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