The PI3K/Akt system is involved in the neuroprotective preconditioning of rats with moderate hypobaric hypoxia

Belyakov, A. V.; Semenov, D. G.

doi:10.1134/s1819712417020039

Cited by 3 publications

(2 citation statements)

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“…26 In addition, Akt, one of the key kinases in many neuroprotective signaling cascades, can be activated during preconditioning of hypoxia. 27 In the current study, the results of Western blot showed that Gyp could obviously increase the levels of p-Akt and p-ERK in the mice, indicating that these two pathways were activated (Figure 5A and B). In addition, our results suggested that the level of p-CREB in the hypobaric hypoxia group was lower than that in control group, and Gyp significantly increased the phosphorylation of CREB, while the total protein was not altered.…”

Section: ■ Results and Discussionsupporting

confidence: 53%

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Dammarane-Type Saponins from Gynostemma pentaphyllum Prevent Hypoxia-Induced Neural Injury through Activation of ERK, Akt, and CREB Pathways

Wang

Zhao

Cheng

et al. 2019

J. Agric. Food Chem.

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Gynostemma pentaphyllum possesses neuroprotective bioactivity. However, the effect of gypenosides on hypoxia-induced neural damage remains obscure. In this study, Gyp, the active fraction extracted from G. pentaphyllum and its bioactive compounds as well as the underlying molecular mechanisms were investigated. Eighteen dammarane-type saponins were isolated from Gyp. The absolute configurations of six unreported compounds (13–18) were assessed via electron capture detection (ECD) analyses. The results of cell viability assay showed that Gyp and its bioactive compounds (13–16 and 18) effectively protected PC12 cells from hypoxia injury. Gyp pretreatment also improved mice spatial memory impairment caused by hypoxia exposure. At the molecular level, Gyp and its bioactive compounds could activate the signaling pathways of ERK, Akt, and CREB in vitro and in vivo. In summary, Gyp and its bioactive compounds could prevent hypoxia-induced injury via ERK, Akt, and CREB signaling pathways.

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Section: ■ Results and Discussionsupporting

confidence: 53%

“…Moreover, hypoxia can downregulate the level of BDNF, inducing dendritic atrophy and neurodegeneration . In addition, Akt, one of the key kinases in many neuroprotective signaling cascades, can be activated during preconditioning of hypoxia …”

Section: Resultsmentioning

confidence: 99%