The pigment of melanosis coli: a lectin histochemical study

Benavides, Sebastián H.; Morgante, P; Monserrat, Alberto J.; Zárate, Jorge; Porta, Eduardo A.

doi:10.1016/s0016-5107(97)70060-9

Cited by 39 publications

(29 citation statements)

References 28 publications

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“…Interestingly, a recent investigation has also revealed an intense argentaffin reaction abolished by bleaching in affected human tissues, which is typical of a melanic substance that may originate from anthranoids and/or their metabolites, most of which are brown. 4 A similar reaction was found in the lymph node of Nero Siciliano pigs with acquired pigmentation following acorn ingestion. 10 Melanosis coli is an uncommon condition in swine that has been identified in multiple unrelated production systems.…”

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confidence: 57%

“…2,16 Lectin-based histochemistry has been used to suggest that the source of the pigment saccharides present in melanosis coli in humans originated from macrophage phagocytosis of apoptotic epithelial cells while also demonstrating that the pigments of melanosis coli have characteristics typical of both lipofuscin and ceroid. 4 Ceroid accumulation has been documented in the small intestine of dogs with intestinal leiomyometaplasia as well as in nutritional panniculitis in cats, mink, foals, and pigs. 12 Insufficient vitamin E, a potent antioxidant embedded in cell membranes, and ingestion of unsaturated fatty acids have been implicated in both conditions.…”

Section: Discussionmentioning

confidence: 99%

“…A lectin-based histochemical technique demonstrated that the pigment in macrophages in the lamina propria was typical of lipofuscin as well as ceroid in humans. 4 Ceroid accumulation has been documented in multiple species and can be associated with vitamin E deficiency and ingestion of unsaturated fatty acids. 12 Vitamin E is a potent antioxidant, and hypovitaminosis E may lead to lipid peroxidation through lack of free radical scavenging.…”

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confidence: 99%

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Evidence of Oxidative Injury in Pigs With Melanosis Coli

et al. 2014

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Melanosis coli is a dark discoloration of the colon due to accumulation of pigment-laden macrophages in the lamina propria. Three case submissions were received where rectal discoloration was reported at slaughter in pigs from separate production systems and melanosis coli was confirmed microscopically. Tissues from affected and unaffected cohort pigs were evaluated for evidence of oxidative damage using immunohistochemical staining for 3-nitrotyrosine, 4-hyroxynonenol, and malondialdehyde. Affected colons had significantly greater immunolabeling for all 3 target compounds than unaffected colons (P .001, all analyses). Hepatic vitamin E levels were low in both affected and unaffected pigs, and there was a trend toward lower values in affected pigs. Given the limited number of slaughter-collected samples available for this investigation, further study is warranted to elucidate the possible association between low vitamin E concentrations and oxidative damage in cases of melanosis coli in pigs.

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confidence: 57%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Evidence of Oxidative Injury in Pigs With Melanosis Coli

et al. 2014

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“…Traditionally, melanosis coli is associated with the chronic ingestion of anthronoid laxatives and commonly found in the elderly. 5 Anthraquinone-induced apoptosis of colonic epithelial cells has been implicated in the pathogenesis of this condition. 6 However, it is also seen in patients who do not use laxatives, possibly due to phagocytosis by macrophages of colonic epithelial cells that have undergone apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Pigmented mesenteric lymphadenopathy in familial adenomatous polyposis - an unusual cause of intraoperative abandonment of ileo-anal pouch

Nigam

Haboubi²,

O’Dwyer³

2005

Ann R Coll Surg Engl

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A n 18-year-old female was referred to the gastroenterology clinic with a 3-month history of postprandial vomiting, colicky lower abdominal pain and 3 kg weight loss. Her bowels were regular with no bleeding or mucous discharge per rectum. She had no urinary or gynaecological symptoms and no significant past history. Her paternal grandfather had died of colon cancer, aged 60 years. She was pale but abdominal examination was unremarkable. Full blood count revealed iron-deficiency anaemia and, at upper GI endoscopy, multiple fundal hyperplastic polyps were identified. Severe duodenitis was present although a Helicobacter pylori urease test was negative. At colonoscopy, numerous polyps carpeted the colon suggesting familial adenomatous polyposis (FAP). Biopsies confirmed the presence of dysplastic adenomata and also revealed submucosal pigmentation suggestive of melanosis coli. Fundoscopy revealed congenital hypertrophy of retinal pigment epithelium (CHRPE) and genetic testing revealed a mutation in the APC gene on chromosome 5. Her parents and sister were screened and found to be free of the disease clinically and not to harbour the mutation.She was counselled with regards to a restorative proctocolectomy but, at operation, multiple enlarged pigmented lymph nodes > 2 cm in diameter were found in the small bowel mesentery. Node biopsy and frozen section showed no evidence of malignancy but the presence of dense pigmentation (Fig. 1)

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“…The pigmentation is actually caused by the accumulation of the degradation substance lipofuscin in macrophages of the lamina propria. 2 Colonic neoplasms typically lack pigment-containing macrophages and therefore are more easily visualized in patients with melanosis coli. 3 SSPs can have a subtle endoscopic appearance and require careful inspection for detection and it may be assumed that colonoscopic detection of SSPs in patients with melanosis coli can be facilitated by the absence of pigmentation in these polyps.…”

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confidence: 99%