The pineal organ of Raja clavata: Opsin immunoreactivity and ultrastructure

Vigh-Teichmann, I.; Vígh, B.; Silva, M. J. Manzano e; Aros, B

doi:10.1007/bf00206272

Cited by 27 publications

(11 citation statements)

References 11 publications

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“…The presence of putative pinealopetal neurons in the dogfish and skate is in agreement with the ultrastructural finding, in the pineal parenchyma, of synaptic boutons that contain dense-cored vesicles and that are clearly different from pinealocyte terminals (Rüdeberg 1969;Vigh-Teichmann et al 1983). Putative pinealopetal cells have been found in the diencephalon and mesencephalon of sturgeon and the mesencephalon of larval lampreys after application of DiI to the pineal organ (Yáñez et al 1993;Yáñez and Anadón 1998).…”

Section: Pinealopetal Neuronssupporting

confidence: 67%

“…Studies of the pineal organ of elasmobranchs (sharks: Studnička 1905;Holmgren 1918;Altner 1965;Rüdeberg 1968Rüdeberg , 1969skates: Vigh-Teichmann et al 1983) have revealed up to five cell types in the pineal parenchyma: photoreceptors, glycogen-storing cells (a receptor cell descendant), supporting cells, cytosome-rich cells (supporting cell descendants), and ganglion cells. Following immunocytochemistry, the outer segments of the pinealocytes of the skate show a strong anti-opsin reaction (Vigh-Teichmann et al 1983). Pineal ganglion cells show acetylcholinesterase activity in a species of shark (Ueck 1979), and, in the dogfish, pineal photoreceptors have been shown to be choline-acetyltransferaseimmunoreactive (Anadón et al 2000).…”

Section: Introductionmentioning

confidence: 98%

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A DiI-tracing study of the neural connections of the pineal organ in two elasmobranchs ( Scyliorhinus canicula and Raja montagui ) suggests a pineal projection to the midbrain GnRH-immunoreactive nucleus

Mandado

Molíst

Anadón

et al. 2001

Cell and Tissue Research

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The pineal organ of elasmobranchs is an elongated photoreceptive organ. In order to investigate the afferent and efferent connections of the pineal organ of two elasmobranchs, the skate (Raja montagui) and the dogfish (Scyliorhinus canicula), a fluorescent carbocyanine (DiI) was applied to the pineal organ of paraformaldehyde-fixed brains. This application strongly labeled the pineal tract, which formed extensive bilateral projections. In both species, the pinealofugal fibers coursed to the dorsomedial thalamus, the medial pretectal area, the posterior tubercle, and the medial mesencephalic tegmentum and branched profusely in these areas. Application of DiI to the pineal organ also labeled occasional perikarya in the dorsomedial thalamus, posterior commissural region, posterior tubercle, and mesencephalic tegmentum. A comparison of these results with those of immunocytochemical analyses of the dogfish brain with an anti-salmon gonadotropin-releasing hormone (sGnRH) antiserum revealed a close topographical relation between the pineal projections and the midbrain sGnRH-immunoreactive (ir) nucleus, the only structure in the dogfish brain that contained sGnRHir neurons. This and the widespread distribution of sGnRHir fibers in the brain suggest that the midbrain sGnRHir nucleus is a part of the secondary pineal pathways and may be involved in light-mediated pineal regulation of brain function. Although GnRH distribution has not been studied in the skate, a midbrain GnRHir nucleus has been identified in three other elasmobranchs, including a skate relative. The probable existence of direct pineal projections to the GnRHir midbrain nucleus in elasmobranchs and other anamniotes is discussed.

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Section: Pinealopetal Neuronssupporting

confidence: 67%

Section: Introductionmentioning

confidence: 98%

A DiI-tracing study of the neural connections of the pineal organ in two elasmobranchs ( Scyliorhinus canicula and Raja montagui ) suggests a pineal projection to the midbrain GnRH-immunoreactive nucleus

Mandado

Molíst

Anadón

et al. 2001

Cell and Tissue Research

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“…Ultrastructurally, the photoreceptor cells are endowed with outer segments that resemble the cones of the retina in the arrangement of their membrane disks (Hyla regilla: EAKIN,1961;EAKIN et al, 1961EAKIN et al, , 1963Rana esculenta, R. temporaria: OKSCHE andVON HARNACK, 1962, 1963;OKSCHE and VAUPEL-VON HARNACK, 1963 pipiens: KELLY and SMITH, 1964;ELDRED and NOLTE, 1981;Xenopus laevis: KORF et al, 1981). However, the antigenicity of the frog pineal photoreceptor has been found to be predominantly of the rod-type (VIGH-TEICHMANN et al, 1980a, 1983a.…”

Section: Discussionmentioning

confidence: 99%

Three types of photoreceptors in the pineal and frontal organs of frogs : Ultrastructure and opsin immunoreactivity.

Vígh

Vigh-Teichmann

1986

Arch. Histol. Jap., Arch. Histol. Jpn

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“…22). The subependymal neuronal perikarya of some cartilagineous fishes send ciliated dendrites into the lumen of the pineal organ (Triakis scyllia: Ueck and Kobayashi, 1979;Raja clavata: Vigh and Vigh-Teichmann, 1989b;Vigh-Teichmann et al, 1983b;Vigh-Teichmann and Vigh, 1989). These nerve cells resemble bipolar neurons of the retina that form Landolt's clubs and have a receptory pole identical to that of hypothalamic CSF-contacting neurons (Fig.…”

mentioning

confidence: 99%

Actual problems of the cerebrospinal fluid-contacting neurons

Vígh

Vigh-Teichmann

1998

Microsc. Res. Tech.

133

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Cerebrospinal fluid (CSF)‐contacting neurons form a part of the circumventricular organs of the central nervous system. Represented by different cytologic types and located in different regions, they constitute a CSF‐contacting neuronal system, the most central periventricular ring of neurons in the brain organized concentrically according to our concept. Because the central nervous system of deuterostomian echinoderm starfishes and the prochordate lancelet is composed mainly of CSF‐contacting‐like neurons, we hypothesize that this cell type represents ancient cells, or protoneurons, in the vertebrate brain. Neurons may contact the ventricular CSF via their dendrites, axons, or perikarya. Most of the CSF‐contacting nerve cells send their dendritic processes into the ventricular cavity, where they form ciliated terminals. These ciliated endings resemble those of known sensory cells. By means of axons, the CSF‐contacting neurons also may contact the external CSF space, where the axons form terminals of neurohormonal type similar to those known in the neurohemal areas. The most simple CSF‐contacting neurons of vertebrates are present in the terminal filum, spinal cord, and oblongate medulla. The dendritic pole of these medullospinal CSF‐contacting neurons terminates with an enlargement bearing many stereocilia in the central canal. These cells are also supplied with a 9 × 2 + 2 kinocilium that may contact Reissner's fiber, the condensed secretory material of the subcommissural organ. The Reissner's fiber floating freely in the CSF leaves the central canal at the caudal open end of the terminal filum in lower vertebrates, and open communication is thus established between internal CSF and the surrounding tissue spaces. Resembling mechanoreceptors cytologically, the spinal CSF‐contacting neurons send their axons to the outer surface of the spinal cord to form neurosecretory‐type terminals. They also send collaterals to local neurons and to higher spinal segments. In the hypothalamic part of the diencephalon, neurons of two circumventricular organs, the paraventricular organ and the vascular sac, of the magnocellular neurosecretory nuclei and several parvocellular nuclei, form CSF‐contacting dendritic terminals. A CSF‐contacting neuronal area also was found in the telencephalon. The CSF‐contacting dendrites of all these areas bear solitary 9 × 2 + 0 cilia and resemble chemoreceptors and developing photoreceptors cytologically. In electrophysiological experiments, the neurons of the paraventricular organ are highly sensitive to the composition of the ventricular CSF. The axons of the CSF‐contacting neurons of the paraventricular organ and hypothalamic nuclei terminate in hypothalamic synaptic zones, and those of magno‐ and parvocellular neurosecretory nuclei also form neurohormonal terminals in the median eminence and neurohypophysis. The axons of the CSF‐contacting neurons of the vascular sac run in the nervus and tractus sacci vasculosi to the nucleus (ganglion) sacci vasculosi. Some hypothalamic CSF‐contacti...

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The pineal organ of Raja clavata: Opsin immunoreactivity and ultrastructure

Cited by 27 publications

References 11 publications

A DiI-tracing study of the neural connections of the pineal organ in two elasmobranchs ( Scyliorhinus canicula and Raja montagui ) suggests a pineal projection to the midbrain GnRH-immunoreactive nucleus

A DiI-tracing study of the neural connections of the pineal organ in two elasmobranchs ( Scyliorhinus canicula and Raja montagui ) suggests a pineal projection to the midbrain GnRH-immunoreactive nucleus

Three types of photoreceptors in the pineal and frontal organs of frogs : Ultrastructure and opsin immunoreactivity.

Actual problems of the cerebrospinal fluid-contacting neurons

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