The Pittsburgh insulin-dependent diabetes mellitus registry: Seasonal incidence

Fishbein, Howard; Re, LaPorte; Orchard, Trevor J.; Drash, A L; Lh, Kuller; Wagener, Diane K.

doi:10.1007/bf01271164

Cited by 35 publications

(10 citation statements)

References 14 publications

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“…The degree of variation emerging from our study compares well with that described by others, in that it is most distinct in boys and older children (13,15,17). Recently published data provided by the EURODIAB ACE study group confirmed a rising amplitude with age, with a similar pattern for boys and girls (16).…”

Section: J F M a M J J A S O N Dsupporting

confidence: 90%

Incidence of IDDM in German Children Aged 0–14 years: A 6-year population-based study (1987–1993)

et al. 1997

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Section: J F M a M J J A S O N Dsupporting

confidence: 90%

Incidence of IDDM in German Children Aged 0–14 years: A 6-year population-based study (1987–1993)

et al. 1997

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“…The pattern of seasonality is similar to that reported in many other studies [8,12,14,[31][32][33][34][35] with excess incidence in the local winter. Some studies have not shown this [17,36].…”

supporting

confidence: 76%

The epidemiology of diabetes mellitus in the United Kingdom: The Yorkshire regional childhood diabetes register

et al. 1993

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Summary. A register of the incidence of Type 1 (insulin-dependent) diabetes mellitus in the Yorkshire region of the United Kingdom has been completed. A total of 1,490 subjects aged between 0 and 16 years were identified from 1978 to 1990, giving an incidence of 13.7 per 100,000 (ages 0-14) or 13.6 per 100,000 (ages 0-16), comparable to other recent studies in the United Kingdom. An age-period-cohort analysis shows evidence for a modest drift effect of 1.75 % per year (95% confidence interval 0.28 to 3.25%). There is a marked epidemic pattern with peaks at 4-year intervals. The age-incidence curve is similar to that reported elsewhere, having peaks in early childhood and puberty. Girls have an earlier pubertal peak than boys. There is substantial seasonal variation in incidence confined to those over 5 years of age. Ascertainment is believed to be very complete, and is estimated to be 97.6% (95% confidence interval 97.2% to 98.1%).Key words: Type 1 (insulin-dependent) diabetes mellitus, epidemiology, aetiology, disease registry, childhood, ascertainment estimates.Type 1 (insulin-dependent) diabetes mellitus is an increasingly common disorder in many European populations [1,2]. Neither the causes of the condition, nor the causes of the increased incidence are known. Although a genetic predisposition is clearly of great importance, direct epidemiological evidence from case-control studies [3,4] and indirect epidemiological evidence from migrant studies [5,6] indicate that environmental agents are also very important.The descriptive epidemiology of Type i diabetes is an important source of information for the framing of aetiological hypotheses. Several prominent features require explanation. There is great geographical variation in incidence, with as much as a 40-fold variation between countries; Finland and Sardinia have the highest incidence rates (over 30 per 100,000 per year); Japan, Africa and Korea have the lowest (0.3 to 2.5 per 100,000 per year) [7][8][9][10][11][12][13]. The age incidence curve typically shows a peak in early adolescence, and may have a secondary peak earlier in childhood. There is marked seasonality of onset in many (though not all) studies [12,[14][15][16][17], although this may relate more to infections precipitating a metabolic decompensation in prediabetic persons, than to any aetiological agent [8]. The incidence in a population may change rapidly during short periods of time, whether in the indigenous population [18], or in migrant populations [5].A necessary first step in any series of investigations of the aetiology of Type 1 diabetes is to establish a good, well-validated register. This was the aim of the Yorkshire project.

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“…It has been found repeatedly that the clinical onset of the disease occurs relatively more frequently in the winter months in both the northern and southern hemispheres (7,8). Possibly, this pattern of seasonality is most pronounced for children with diagnosis around puberty and less pronounced for those with onset within the first years of life (6).…”

Section: A Greenmentioning

confidence: 96%

Descriptive Epidemiology of Type 1 Diabetes in Youth: Incidence, Mortality, Prevalence, and Secular Trends

Green

2008

Endocrine Research

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The Pittsburgh insulin-dependent diabetes mellitus registry: Seasonal incidence

Cited by 35 publications

References 14 publications

Incidence of IDDM in German Children Aged 0–14 years: A 6-year population-based study (1987–1993)

Incidence of IDDM in German Children Aged 0–14 years: A 6-year population-based study (1987–1993)

The epidemiology of diabetes mellitus in the United Kingdom: The Yorkshire regional childhood diabetes register

Descriptive Epidemiology of Type 1 Diabetes in Youth: Incidence, Mortality, Prevalence, and Secular Trends

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