The pituitary-adrenal response to novel stimulation and ether stress in young adult and aged rats

Brett, Linda P.; Chong, Gary S.; Coyle, Sallyeana; Levine, Seymour

doi:10.1016/0197-4580(83)90037-4

Cited by 69 publications

(23 citation statements)

References 34 publications

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“…ACTH responses to acute stress are diminished in aging [20], Adrenocortical responsiveness is reported to be increased [21] or decreased [22] by stressors and ACTH. Our results may reflect HPA dysfunction associated with aging related to antipsychotic drugs.…”

Section: Discussionmentioning

confidence: 98%

Depressed Pituitary-Adrenal Response to Surgical Stress in Chronic Schizophrenic Patients

Kudoh

Kudo²,

Ishihara³

et al. 1997

Neuropsychobiology

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We evaluated whether pituitary-adrenal response to surgical stress is modified in chronic schizophrenic patients. Twenty-two schizophrenic patients on chronic antipsychotic therapy of phenothiazine derivatives over 10 years underwent orthopedic surgery of the extremities under general anesthesia by isoflurane and nitrous oxide. In chronic schizophrenic patients, responses of plasma epinephrine, norepinephrine, ACTH and cortisol levels during surgical stress were significantly lower than those of control patients. The attenuated response to surgical stress in these patients may be associated with their autonomic dysfunction and decreased pituitary-adrenal activity due to chronic administration of antipsychotic agents.

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Section: Discussionmentioning

confidence: 98%

Depressed Pituitary-Adrenal Response to Surgical Stress in Chronic Schizophrenic Patients

Kudoh

Kudo²,

Ishihara³

et al. 1997

Neuropsychobiology

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“…Chronic corticosterone treatment suppresses the expression of 5-HT 1A receptor mRNA selectively in the dentate gyrus (Meijer and De Kloet, 1994) and induces a reduction of [ 3 H]8-OH-DPAT binding that is confined to the dentate gyrus and the oriens and lacunosum moleculare layers of CA4 (Mendelson and McEwen, 1992). It may be an obvious conclusion that the higher basal plasma corticosterone level and the prolonged plasma corticosterone stress response during aging (Hess and Reigle, 1970;Brett et al, 1983;Sapolsky et al, 1983;Van Eekelen et al, 1991;Korte et al, 1992Korte et al, , 1996 may be a major factor underlying the age-dependent selective loss of 5-HT 1A receptors in the dentate gyrus.…”

Section: Discussionmentioning

confidence: 99%

Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging

Nyakas

Oosterink

Keijser

et al. 1997

Journal of Chemical Neuroanatomy

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Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging Nyakas, C; Oosterink, BJ; Felszeghy, K; deJong, GI; Korf, J; Luiten, PGM; Keijser, Jan N. Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Nyakas, C., Oosterink, BJ., Felszeghy, K., deJong, GI., Korf, J., Luiten, PGM., & Keijser, J. N. (1997). Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging. Journal of Chemical Neuroanatomy, 13(1), 53-61. https://doi.org/10.1016/S0891-0618(97)00025-2 Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. AbstractThe effect of aging on 5-HT 1A receptor binding in several forebrain areas associated with the basal forebrain cholinergic system was investigated in rats of 3-, 24-and 30-months-old by receptor autoradiography and biochemical binding assay using [ 3 H]8-OH-DPAT as a ligand. Autoradiographic measurements demonstrated a marked region-specific decline of ligand binding in: (i) regions of the basal forebrain cholinergic cell groups, i.e. the medial septum, diagonal band nuclei and magnocellular nucleus basalis, (ii) the frontal and parietal neocortex and (iii) the dentate gyrus of the hippocampus. No change or only a slight decrease of the 5-HT 1A receptor density was found in other areas investigated: the CA1 and CA3 sectors of hippocampus, the cingular and perirhinal cerebral cortex and the lateral septum. The autoradiographic findings were substantiated by the biochemical binding assay, which revealed a comparable loss of 5-HT 1A receptor in the hippocampus and neocortex at the age of 30 months. The results clearly show that with increasing age the decrement of 5-HT 1A receptor binding in the rat forebrain is remarkably region-selective and particularly affects the cholinergic cell groups that innervate cortex and hippocampus. This phenomenon appears to be especially significant in relation to the neuronal substrates underlying the age-related alterations of mood and cognition. © 1997 Elsevier Science B.V.

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“…However, the mean plasma concentration of corticosterone was elevated in aged rats.  Brett et al, [435] found no change with age (young 3-to 6-mo vs old 24-to 27-mo) in either sex in basal corticosterone levels, no change with age in males in stress-induced increments in corticosterone, and no change with age in males in stress-induced elevations in corticosterone, but a reduction in elevations induced by more potent stressors.  Sapolsky et al, [436] reported elevation of basal corticosterone levels with advancing age (ranging from 3-to 27 months of age).…”

Section: Fisher 344 (F344) Ratsmentioning

confidence: 94%

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Zaidi¹

2013

TOLSJ

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Steroid hormones are lipophilic, low-molecular weight organic compounds all of which are derived from cholesterol. They are primarily synthesized by steroidogenic glands such as gonads (ovary and testis), the adrenal gland and, during pregnancy, by the placental trophoblasts. Limited steroid synthesis also takes place in the brain. Steroid hormones are crucial for the proper functioning of the body. They mediate a wide variety of vital physiological functions, ranging from maintaining normal reproductive function and secondary sexual characteristics, to regulating virtually every metabolic process in the body. Like many age-related endocrine disorders, aging also progressively impacts the tissue-specific synthesis and secretion of steroid hormones. The goal of this review is to summarize the effects of aging on steroid hormone synthesis and secretion by the adrenal gland and gonads of both human and experimental animal models, to describe the potential involvement of excessive oxidative stress in mediating age-related alterations in steroidogenesis, and to discuss the possible underlying mechanisms involved.

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The pituitary-adrenal response to novel stimulation and ether stress in young adult and aged rats

Cited by 69 publications

References 34 publications

Depressed Pituitary-Adrenal Response to Surgical Stress in Chronic Schizophrenic Patients

Depressed Pituitary-Adrenal Response to Surgical Stress in Chronic Schizophrenic Patients

Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

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