The Pituitary and Adrenal Cortex in General Medicine

Nabarro, J. D. N.

doi:10.1136/bmj.2.5199.625

BMJ

1960

DOI: 10.1136/bmj.2.5199.625

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The Pituitary and Adrenal Cortex in General Medicine

J. D. N. Nabarro¹

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1961

1983

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Cited by 9 publications

(1 citation statement)

References 18 publications

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“…Osteoporosis: Collapse of the lower dorsal or lumbar vertebrae is a well known complication of Cushings disease.• Similarly this may occur in patients on steroid therapy and it is secondary to the severe osteoporosis which occasionally results. Nabarro (1960) had three cases of vertebral collapse in 322 patients receiving this long-term treatment. The healing of fractures, however, is not usually delayed (Rosenberg 1958).…”

mentioning

confidence: 99%

Surgical Problems Resulting from Steroid Therapy

Winstone¹

1962

Int J Clinical Practice

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mentioning

confidence: 99%

Surgical Problems Resulting from Steroid Therapy

Winstone¹

1962

Int J Clinical Practice

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Chemical immunosuppression and human cancer

Penn¹

1974

Cancer

152

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A significant advance in our understanding of cancer is the realization that states of immunodeficiency are associated with an increased incidence of malignancies. Malignant cells have been inadvertently transplanted with homografts obtained from donors with cancer. In the immunosuppressed host such cells have survived, multiplied, and spread. In addition, organ homograft recipients have shown a 5.6% incidence of de novo malignancies at some time after transplantation. Organ transplant recipients who had pre‐existing malignancies removed developed recurrences or metastases of the original neoplasms in 41% of cases. Malignancies have also been observed in nontransplant patients treated for a variety of disorders. Cancer chemotherapeutic agents have immunosuppressive side effects; patients have manifested new malignancies while their original tumors were controlled by the antineoplastic drugs. The danger of malignancy makes it imperative that immunosuppressive therapy should only be used when strongly indicated, as in organ transplantation, or where other forms of therapy have failed to control the patient's disease. The use of the appropriate cancer themotherapeutic agents in patients with advanced malignancies is fully justified, as the risk of development of new tumors is far outweighed by the months or years of control of the original neoplasms. Chemotherapy, as an adjuvant to radiotherapy or surgery in the management of localized cancers, should be used with caution as it has yielded disappointing results in many series.

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The treatment of rheumatoid arthritis

Wright

1963

Journal of Chronic Diseases

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The Pituitary and Adrenal Cortex in General Medicine

Cited by 9 publications

References 18 publications

Surgical Problems Resulting from Steroid Therapy

Surgical Problems Resulting from Steroid Therapy

Chemical immunosuppression and human cancer

The treatment of rheumatoid arthritis

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