The pituitary-ovarian axis in dogs with remnant ovarian tissue

Buijtels, J.J.C.W.M.; Gier, J. De; Kooistra, H.S.; Naan, E.C.; Oei, Christine; Okkens, A.C.

doi:10.1016/j.theriogenology.2010.10.015

Cited by 12 publications

(26 citation statements)

References 33 publications

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“…In ORS bitches, the pituitary–ovarian axis is still active in a regular fashion. Thus, GnRH stimulation in ORS bitches could result in elevated serum oestradiol and progesterone concentrations (Buijtels et al., ). The diagnosis of ORS has been made based on clinical examination of the bitches and elevated ovarian steroid concentrations with or without GnRH stimulation, which is insufficient and inadequate at anoestrous phase of sexual cycle.…”

Section: Discussionmentioning

confidence: 99%

Does serum anti‐Müllerian hormone levels always discriminate presence of the ovaries in adult bitches? Comparison of two ELISA kits

Yağci

Pekcan

Polat

et al. 2016

Reprod Domestic Animals

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Anti-Müllerian hormone (AMH) is produced in the ovary, and thus, it is an excellent marker of follicle pool in females. Current interest is the clinical use of this parameter as a biomarker to assess presence or absence of an intact ovary and to diagnose ovarian remnant syndrome (ORS) following incomplete ovariohysterectomy (OHE) in bitches. The aim of this study was to evaluate serum AMH concentrations in bitches (n = 34) before and after OHE using two different commercial ELISA kits, one of which is based on detecting human AMH and the other is based on detecting human AMH and the other specified for canine AMH. Furthermore, serum AMH levels were also measured in six ORS cases to compare the diagnostic utility of the two different ELISA kits. Serum AMH concentrations measured using the human and canine kit prior to and after OHE were 0.32 ± 0.24, 0.006 ± 0.22 ng/ml (p < .001) and 12.08 ± 22.81, 9.55 ± 15.42 ng/ml (p = .868), respectively. Thus, the canine-based kit was not able to reveal the significant drop in serum AMH levels. In conclusion, the human-based ELISA kits successfully detected the drop in serum AMH concentrations. Reliable results can only be achieved from well-designed ELISA kits, and AMH levels might be a useful diagnostic tool for the evaluation of presence or absence of ovaries as well as for the detection of ORS cases in bitches.

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Section: Discussionmentioning

confidence: 99%

Does serum anti‐Müllerian hormone levels always discriminate presence of the ovaries in adult bitches? Comparison of two ELISA kits

Yağci

Pekcan

Polat

et al. 2016

Reprod Domestic Animals

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“…Das Ovarrest-Syndrom (ORS) ist definiert als Auftreten klinischer Symptome, die bei einem Tier nach vorangegangener Ovarektomie oder Ovariohysterektomie durch verbliebenes funktionelles Ovargewebe hervorgerufen werden (2,3,12). Die Ovarreste finden sich typischerweise an der ursprünglichen Lokalisation der Eierstöcke, weshalb ein Operationsfehler als wahrscheinlichste Ursache des ORS angenommen wird (2).…”

Section: Introductionunclassified

“…Tiere mit ORS werden mit sehr vielfältigen Symptomen vorgestellt, die mit der endogenen Hormonproduktion durch das Ovarrest-Gewebe in Zusammenhang stehen (2,3,12,16). Das ORS manifestiert sich in der Regel in Form von Symptomen des Proöstrus oder Östrus wie Vulvaschwellung, blutig-wässriger Vaginalausfluss und Östrusverhalten (2,16).…”

Section: Introductionunclassified

“…Das ORS manifestiert sich in der Regel in Form von Symptomen des Proöstrus oder Östrus wie Vulvaschwellung, blutig-wässriger Vaginalausfluss und Östrusverhalten (2,16). Der Zeitraum zwischen Einsetzen der klinischen Symptomatik und der Ovarektomie variiert stark (2,3,9). Die klinischen Anzeichen können periodisch auftreten oder permanent vorhanden sein (3).…”

Section: Introductionunclassified

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Magnetresonanztomographie und Laparoskopie zur Diagnose und Behandlung eines Ovarrest-Syndroms bei einer Hündin

Krauss

Krauß²

2015

Tierarztl Prax Ausg K

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Ovarian remnant tissue was diagnosed in a 6-year-old female Pointer presented with a history of periodic signs of oestrus after ovariohysterectomy. The diagnosis was based on clinical gynaecological examination, vaginoscopy, vaginal cytology, analysis of serum progesterone concentration, and magnetic resonance imaging. The ovarian remnant tissue was approached in a minimally invasive manner via laparoscopy and resected with a vessel-sealing system. The oestrus signs disappeared within 14 days after laparoscopy.

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“…A hormone challenge test using either hCG or GnRH has been used to demonstrate a rise in progesterone in animals with ovarian remnants . In spayed bitches, LH levels are higher than in bitches with remnant or intact ovarian tissue . An exception to this is when a short duration (< 24 h) LH peak occurs during the oestrous cycle to initiate ovulation …”

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confidence: 99%

Low sensitivity of a test for anti‐Mullerian hormone to assess presence of ovaries in prepubertal bitches

et al. 2018

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The pituitary-ovarian axis in dogs with remnant ovarian tissue

Cited by 12 publications

References 33 publications

Does serum anti‐Müllerian hormone levels always discriminate presence of the ovaries in adult bitches? Comparison of two ELISA kits

Does serum anti‐Müllerian hormone levels always discriminate presence of the ovaries in adult bitches? Comparison of two ELISA kits

Magnetresonanztomographie und Laparoskopie zur Diagnose und Behandlung eines Ovarrest-Syndroms bei einer Hündin

Low sensitivity of a test for anti‐Mullerian hormone to assess presence of ovaries in prepubertal bitches

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