The Pivotal Role of CK2 in the Kinome‐Targeting Hsp90 Chaperone Machinery

Miyata, Yoshihiko

doi:10.1002/9781118482490.ch7

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Protein Kinase Ck2 and The Er Stress Response1

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2013

2015

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“…Binding of HSP90 to CK2 enhances the kinase activity of CK2 and prevents aggregation and inactivation of CK2 [23,24]. The role of CK2 in the chaperone machinery is nicely reviewed by Miyata [25], and is therefore not further addressed in the present review.…”

Section: Protein Kinase Ck2 and The Er Stress Responsementioning

confidence: 99%

Protein kinase CK2 in the ER stress response

Götz¹,

Montenarh²

2013

ABC

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The endoplasmic reticulum is the central organelle within a eukaryotic cell where newly synthesized proteins are processed and properly folded. An excess of unfolded or mis-folded proteins induces ER stress signalling pathways. Usually this means a pro-survival strategy for the cell, whereas under extended stress conditions the ER stress signalling pathways have a pro-apoptotic function. CK2 plays a key role in the regulation of the pro-survival as well as the proapoptotic ER stress signalling by directly modulating the activities of members of the ER stress signalling pathways by phosphorylation, regulating the expression of the key factors of the signalling pathways or binding to regulator proteins. The present review will summarize the state of the art in this new emerging field.

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Section: Protein Kinase Ck2 and The Er Stress Responsementioning

confidence: 99%