The pivotal role of tricuspid regurgitation in the failing systemic right ventricle: The “chicken and egg story”

Silini, Alexandre; Avesani, Martina; Houyel, Lucile; Thambo, Jean-Benoît; Iriart, Xavier

doi:10.1016/j.acvd.2022.05.004

Cited by 5 publications

(2 citation statements)

References 79 publications

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“…In addition, tricuspid regurgitation can be one of the causes and one of the effects of systemic right ventricular dysfunction as well ( 107 ). Tricuspid valve, in fact, can be congenitally altered and mechanisms like annulus dilatation and septal leaflet traction due to right-to-left septal shift can worsen valve regurgitation.…”

Section: Systemic Rv In Biventricular Physiologymentioning

confidence: 99%

The mechanics of congenital heart disease: from a morphological trait to the functional echocardiographic evaluation

Avesani,

Sabatino,

Borrelli

et al. 2024

Front. Cardiovasc. Med.

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Advances in pediatric cardiac surgery have resulted in a recent growing epidemic of children and young adults with congenital heart diseases (CHDs). In these patients, congenital defects themselves, surgical operations and remaining lesions may alter cardiac anatomy and impact the mechanical performance of both ventricles. Cardiac function significantly influences outcomes in CHDs, necessitating regular patient follow-up to detect clinical changes and relevant risk factors. Echocardiography remains the primary imaging method for CHDs, but clinicians must understand patients' unique anatomies as different CHDs exhibit distinct anatomical characteristics affecting cardiac mechanics. Additionally, the use of myocardial deformation imaging and 3D echocardiography has gained popularity for enhanced assessment of cardiac function and anatomy. This paper discusses the role of echocardiography in evaluating cardiac mechanics in most significant CHDs, particularly its ability to accommodate and interpret the inherent anatomical substrate in these conditions.

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Section: Systemic Rv In Biventricular Physiologymentioning

confidence: 99%

The mechanics of congenital heart disease: from a morphological trait to the functional echocardiographic evaluation

Avesani,

Sabatino,

Borrelli

et al. 2024

Front. Cardiovasc. Med.

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“…Case reports and series implanting clips in the SAVV tricuspid position in d-TGA and cc-TGA have also reported good clinical and echocardiographic improvement ( 115 ). Albeit more extensive studies with longer follow-ups are needed for validation, this percutaneous-based clip implantation may be suitable for sRV patients at high surgical risk ( 116 ).…”

Section: Management Of the Failing Systemic Right Ventriclementioning

confidence: 99%

Heart failure in systemic right ventricle: Mechanisms and therapeutic options

Sabbah

Arabi

Shafqat

et al. 2023

Front. Cardiovasc. Med.

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d-loop transposition of the great arteries (d-TGA) and congenitally corrected transposition of the great arteries (cc-TGA) feature a right ventricle attempting to sustain the systemic circulation. A systemic right ventricle (sRV) cannot support cardiac output in the long run, eventually decompensating and causing heart failure. The burden of d-TGA patients with previous atrial switch repair and cc-TGA patients with heart failure will only increase in the coming years due to the aging adult congenital heart disease population and improvements in the management of advanced heart failure. Clinical data still lags behind in developing evidence-based guidelines for risk stratification and management of sRV patients, and clinical trials for heart failure in these patients are underrepresented. Recent studies have provided foundational data for the commencement of robust clinical trials in d-TGA and cc-TGA patients. Further insights into the multifactorial nature of sRV failure can only be provided by the results of such studies. This review discusses the mechanisms of heart failure in sRV patients with biventricular circulation and how these mediators may be targeted clinically to alleviate sRV failure.

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Replacement of the systemic tricuspid valve in a patient with corrected transposition of the great arteries, ventricular septal defect, and Eisenmenger syndrome

Gorbachevsky,

Shmalts,

Chernogrivov

et al. 2024

Indian J Thorac Cardiovasc Surg

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The pivotal role of tricuspid regurgitation in the failing systemic right ventricle: The “chicken and egg story”

Cited by 5 publications

References 79 publications

The mechanics of congenital heart disease: from a morphological trait to the functional echocardiographic evaluation

The mechanics of congenital heart disease: from a morphological trait to the functional echocardiographic evaluation

Heart failure in systemic right ventricle: Mechanisms and therapeutic options

Replacement of the systemic tricuspid valve in a patient with corrected transposition of the great arteries, ventricular septal defect, and Eisenmenger syndrome

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