The place of antibiotics in colonic surgery: A clinical study

Everett, M. T.; Brogan, T. D.; Nettleton, Joyce A.

doi:10.1002/bjs.1800560911

Cited by 53 publications

(20 citation statements)

References 11 publications

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“…Surveillance of SSI with feedback of appropriate data to surgeons has been shown to be an important component of strategies to reduce SSI risk [26,27].A successful surveillance program includes the use of epidemiologically sound infection definitions and effective surveillance methods, stratification of SSI rates according to risk factors associated with SSI development and data feedback. Hence a number of antibiotics prescribed after surgery can play a major role in the prevention of surgical site infection [28][29][30]. Surveillance on a number of antibiotics used post-surgery will give the surgeons an appropriate data to prescribe antibiotics, reduce the number of antibiotics post-surgery which will reduce the burden on patient's pocket or increasing the number of antibiotics in cases where there is a higher risk of surgical site infection.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Two or More Antibiotics Regimen Versus One or No Antibiotic Regimen in Post-Operative Surgery

Mihirkumar¹,

Ashley²,

Nawaz³

et al. 2017

Int J Pharm Pharm Sci

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Objective: Surgical site infections [SSI] are the leading cause of hospital-acquired infections. The objective of this study was to evaluate whether surgical site infections can be reduced with twoormoreantibioticsregimenversusoneornoantibioticregimeninpost-operativesurgery. Methods:The patients were grouped into 2 groups. Group A (two or more antibiotics regimen) and Group B (one or no antibiotic regimen). Then the patients were followed on 1st, 2nd, 3rd and 4th week respectively after surgery to check for any surgical site infection by direct interviewing the patients. Results:The overall surgical site infection rate was 48.3% (58 out of 120 patients).However, this study was more dominated by female patientsthere were 63% female patients compared to 37% male patients enrolled in this study. Also, the post-operative surgical site infection was comparatively observed more in female patients than in male. General surgery department too had many gynaecology related patients followed by Orthopaedic and Endocrinology surgeries. Results revealed that the patients in Group A (Two or more antibiotics) had significantly lower number of surgical site infections when compared with Group B (One or no antibiotics) with p<0.001. Conclusion:Our study concludes that patients receiving two or more antibiotics had significantly less number of post-operative surgical site infections when compared to patients receiving one or no antibiotics and following two or more antibiotics can reduce the excess hospital cost.

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Section: Introductionmentioning

confidence: 99%

Assessment of Two or More Antibiotics Regimen Versus One or No Antibiotic Regimen in Post-Operative Surgery

Mihirkumar¹,

Ashley²,

Nawaz³

et al. 2017

Int J Pharm Pharm Sci

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“…Especially the idea of decreasing postoperative complications such as anastomotic dehiscences, intra-abdominal septic complications and wound infections was nourished by the fact that these kinds of complications caused about half of the postoperative deaths in earlier patient series [5, 6]. Since both the rate of anastomotic dehiscences and infections were attributed to an elevated intestinal contamination [7, 8], emptying the colon of its content seemed to be a logical step prior to interventions. Thus, preoperative bowel cleaning was established as a dogma in the early seventies [8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Preoperative Bowel Preparation: Surgical Standard or Past?

Müller‐Stich

Choudhry²,

Vetter³

et al. 2006

Dig Surg

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Background: Preoperative bowel preparation is still routinely used prior to colorectal surgery. This concept is based on traditional and personal empiricism and usually not evidence based. The objective of the present review was to reassess this dogma against the background of the highest level of evidence published thus far. Methods: The Medline database was searched using the search terms ‘preoperative’, ‘bowel’ and ‘preparation’ limited to ‘randomized controlled trials’ and ‘meta-analyses’. Ten randomised controlled trials and seven meta-analyses comparing orthograde bowel cleansing to no preoperative bowel preparation were considered for rates of anastomotic leakages, surgical infections and other types of complications, reoperations and mortality. Results: All the most recent meta-analyses showed a significant increase of anastomotic dehiscences in patients with preoperative orthograde bowel cleansing. Additionally, a trend towards higher rates of surgical infectious complications and re-operations was revealed. Mortality remained unchanged by preoperative orthograde bowel cleansing. Conclusion: Routine preoperative orthograde bowel cleansing is no longer justified prior to colorectal surgery in general due to increased risk of anastomotic leakages. Further investigations should focus on different types of bowel preparation in situations where preoperative bowel preparation still may have a role such as total mesorectal resection with low anastomosis and protective ileostomy.

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“…Without any antibiotic prophylaxis, the inci dence of postoperative wound infection is 30-60% [1][2][3][4], Significant reductions in the incidence of postopera tive septic complications after colorectal surgery can be achieved by mechanical and antibiotic bowel prepara tion [5][6][7], However, reports on investigations of postop erative abdominal infectious complications following to tal cystectomy with ileal urinary diversion [8] as well as of preventive preoperative preparation of the bowel [9] have been rare. This report describes an investigation of postoperative abdominal infectious complications and discusses two regimens for preoperative prophylactic antibiotic bowel preparation in patients who underwent total cystectomy with ileal urinary diversion.…”

Section: Introductionmentioning

confidence: 99%

Preoperative Oral and Postoperative Parenteral Antibiotic Prophylaxis of Wound Infection in Total Cystectomy with Heal Urinary Diversion

Tanaka¹,

Matsumoto²,

Ogata³

et al. 1991

Urol Int

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We describe an investigation of postoperative abdominal infectious complications and discuss two regimens for preoperative antibiotic bowel preparation in cases who underwent total cystectomy with ileal urinary diversion. Ten cases (28.6%) of 35 who had been operated developed abdominal infectious complications. Six showed abdominal wound infection, 2 showed intrapelvic abscess and 2 showed abdominal wound infection with intrapelvic abscess. Of the 19 strains of organisms isolated from the postoperative infections, 11 (57.9%) were anaerobic bacteria and the most commonly isolated bacteria was Bacteroides. A significantly lower incidence of postoperative infection was found in cases who had received tobramycin and vancomycin (0%) than in those who had received kanamycin alone (41.7%). These results indicate that anaerobic bacteria are the major contributors to postoperative infections following total cystectomy with ileal urinary diversion and that tobramycin-vancomycin prophylaxis greatly reduces the incidence of postoperative infections.

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The place of antibiotics in colonic surgery: A clinical study

Cited by 53 publications

References 11 publications

Assessment of Two or More Antibiotics Regimen Versus One or No Antibiotic Regimen in Post-Operative Surgery

Assessment of Two or More Antibiotics Regimen Versus One or No Antibiotic Regimen in Post-Operative Surgery

Preoperative Bowel Preparation: Surgical Standard or Past?

Preoperative Oral and Postoperative Parenteral Antibiotic Prophylaxis of Wound Infection in Total Cystectomy with Heal Urinary Diversion

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