The place of beta-adrenergic receptor blockers in the treatment of arterial hypertension: From bench-to-bedside

Avagimyan, Ashot; Kajaia, Nana; Gabunia, Luiza; Trofimenko, Artem; Sulashvili, Nodar; Sanikidze, Tamar; Gorgaslidze, Nana; Challa, Abhiram; Sheibani, Mohammad

doi:10.1016/j.cpcardiol.2024.102734

Current Problems in Cardiology

2024

DOI: 10.1016/j.cpcardiol.2024.102734

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The place of beta-adrenergic receptor blockers in the treatment of arterial hypertension: From bench-to-bedside

Ashot Avagimyan,

Nana Kajaia,

Luiza Gabunia

et al.

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2024

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Cited by 1 publication

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Efficacy of Different Beta Blockers in Reducing Mortality in Heart-Failure Patients

Roghani,

Khan,

Shafiq

et al. 2024

Cureus

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This study evaluated the comparative efficacy of different beta blockers bisoprolol, carvedilol, and metoprolol in reducing mortality and hospitalizations among 120 heart-failure (HF) patients. The sample had an equal gender distribution (50% male, 50% female) with a mean age of 69.28 years. Baseline characteristics, such as systolic blood pressure (mean: 134.36 mmHg) and left ventricular ejection fraction (LVEF) (mean: 40.24%), were comparable across the treatment groups. Patients were treated with either bisoprolol (30%), carvedilol (30%), or metoprolol (40%) for an average of 27.54 weeks. The study utilized Poisson and negative binomial regression models to assess hospitalization rates, and chi-square tests to compare mortality outcomes. Results revealed that mortality was 44.2% across the entire cohort, with no significant differences between the three beta-blocker groups (p = 0.301). Similarly, no significant differences were observed in hospitalizations (p = 0.276) or ICU admissions (p = 0.797). However, patients on bisoprolol and carvedilol exhibited a slight improvement in New York Heart Association (NYHA) class and LVEF, though this was not statistically significant (p = 0.145 and p = 0.477, respectively). Side effects, including bradycardia, fatigue, and hypotension, were noted in 32.5%, 21.7%, and 23.3% of patients, respectively. These findings suggest that all three beta blockers are similarly effective in reducing mortality, though bisoprolol and carvedilol may offer better control of HF symptoms.

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Efficacy of Different Beta Blockers in Reducing Mortality in Heart-Failure Patients

Roghani,

Khan,

Shafiq

et al. 2024

Cureus

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The place of beta-adrenergic receptor blockers in the treatment of arterial hypertension: From bench-to-bedside

Cited by 1 publication

References 102 publications

Efficacy of Different Beta Blockers in Reducing Mortality in Heart-Failure Patients

Efficacy of Different Beta Blockers in Reducing Mortality in Heart-Failure Patients

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