The place of botulinum toxin type A in the treatment of focal hyperhidrosis

Lowe, Nicholas J.; Campanati, Anna; Bodokh, Isaac; Cliff, S.; Jaén, Pedro; Kreyden, Oliver P; Naumann, Markus; Offidani, Annamaria; Vadoud, Javid; Hamm, Henning

doi:10.1111/j.1365-2133.2004.06317.x

Cited by 95 publications

(70 citation statements)

References 48 publications

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“…In most studies presented in the literature, the authors concentrate on relative impact of different forms of treatment on gravimetrically measured sweating [3,4,[10][11][12][13][14][15][16][17][18][19]. Mostly, such measurements were performed in dermatological settings and concerned the results of botox treatment [3,4,[13][14][15][16][17]19] or iontophoresis [12].…”

Section: Discussionmentioning

confidence: 99%

“…Mostly, such measurements were performed in dermatological settings and concerned the results of botox treatment [3,4,[13][14][15][16][17]19] or iontophoresis [12]. In those methods of treatment, associated with low level of transient complications or side effects, even less stringent approach to qualification will not cause longterm harm to the patients.…”

Section: Discussionmentioning

confidence: 99%

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Gravimetry in Sweating Assessment in Primary Hyperhidrosis and Healthy Individuals

Stefaniak¹

2017

Agache's Measuring the Skin

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Objective Though hyperhidrosis is generally considered a subjectively perceived disease, it seems more and more doubtful that merely subjective evaluation is sufficient to qualify the patient to surgery. The aim of this study was to develop further gravimetry as a method of evaluation of sweating intensity and determination of the applicability of it in post-operative follow-up of primary hyperhidrosis (PHH) patients. Methods Total of 1,485 gravimetry assays has been performed in 343 patients treated for hyperhidrosis and in 220 healthy volunteers. In all of the subjects the measurements were taken from four localizations (face, hands, armpits and trunk) and normalized by body surface of the participant. The measurements were taken twice for every participant to obtain test-retest correlations. Mean values and standard deviations (SD) have been evaluated and on that basis reference values were quantified. Thresholds for diagnosis of hyperhidrosis were quantified on the basis of normal distribution theory as healthy population mean ?2 SD. Interpretation Gravimetry is easy, reproducible and fast method of evaluation of sweating. The reference values are stable and can serve as a qualifying and follow-up tool for evaluation of the patients with PHH in any localization.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gravimetry in Sweating Assessment in Primary Hyperhidrosis and Healthy Individuals

Stefaniak¹

2017

Agache's Measuring the Skin

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“…Die Anwendung erfolgt initial meist 5-mal pro Woche und wird nach therapeutischem Ansprechen als Erhaltungsdosis auf 1-bis 2-mal wöchentliche Anwendungen reduziert [22,23]. Die Stromstärke kann individuell angepasst werden; moderne Geräte bieten darüber hinaus Schutzfunktionen gegenüber dem sog.…”

Section: Leitungswasser-iontophoreseunclassified

Hyperhidrose im Kindes- und Jugendalter

2011

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Hyperhidrosis is characterized by localized or general excessive sweating which is severe enough to be perceived as pathological. Since excessive sweating often starts in childhood and adolescence, usually in children between 6 and 16 years of age, hyperhidrosis is an important disorder for children and juveniles. This condition causes considerable disruption of both social life and educational career, leading to severe deterioration in the patient's quality of life. In addition, therapy is often challenging since many treatment modalities are not approved for children. Nonetheless, there are still effective therapeutic options for children with hyperhidrosis.

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“…Contradictory evidence was reported in patients diagnosed with anxiety neuroses with increased concentrations of circulating catecholamines, who were shown to be more responsive than normal controls to local injections of the cholinomimetic carbachol and phenylephrine [77,78,79]. However, as the intradermal injection of Botox is highly effective at preventing sweating [80], circulating catecholamines on their own are not capable of eliciting the primary sweat response during periods of acute psychological stress [81], suggesting that the humoral factors play little or no role in the activation of eccrine sweat glands. Sex steroid hormone concentrations have been shown to increase in the initial phase of acute psychosocial stress, though there is no evidence to suggest that they are directly responsible for the innervation of eccrine or apocrine sweat glands [82].…”

Section: Humoral Control Of Psychological Sweatingmentioning

confidence: 99%

Psychological Sweating: A Systematic Review Focused on Aetiology and Cutaneous Response

Harker¹

2013

Skin Pharmacol Physiol

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Psychological sweating in response to emotive stimuli like stress, anxiety and pain occurs over the whole body surface, but is most evident on the palms, soles, face and axilla. This is primarily a consequence of high eccrine sweat gland densities at these body sites. Cholinergic innervation is the primary effector eliciting activation of eccrine sweat glands during periods of acute psychological stress. A dual innervation pathway for eccrine glands (adrenergic and cholinergic) may augment increased sweat output, but this remains to be substantiated. Circulating catecholamines appear not to mediate eccrine gland activity, but may play a role in the activation of apocrine sweat glands. Apocrine sweating is strongly regulated by psychological stimuli and localised to those body sites hosting apocrine glands, with adrenergic peripheral pathways being the primary effector. Accordingly, in the axilla psychological sweating leads to increased sweat output and malodour formation, although this form of sweating at this body site is not observed until puberty.

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The place of botulinum toxin type A in the treatment of focal hyperhidrosis

Cited by 95 publications

References 48 publications

Gravimetry in Sweating Assessment in Primary Hyperhidrosis and Healthy Individuals

Gravimetry in Sweating Assessment in Primary Hyperhidrosis and Healthy Individuals

Hyperhidrose im Kindes- und Jugendalter

Psychological Sweating: A Systematic Review Focused on Aetiology and Cutaneous Response

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