The place of omega-3 and omega-6 acids in supplementary treatment of inflammatory joint diseases

Kwiatkowska, Brygida; Maślińska, Maria

doi:10.5114/reum.2020.93511

Cited by 5 publications

(3 citation statements)

References 57 publications

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“…Both, EPA and DHA supplementation was discovered to increase membrane fluidity and lipid raft clustering leading to Other important PUFAs involved in inflammation and allergy are the ω-3 acids eicosapentaenoic acid (EPA, 20:5) and docosahexaenoic acid (DHA, 22:6) (Figure 2). The supplementation of these ω-3 acids with diet was previously associated with favorable outcomes in a variety of disease models [147][148][149][150][151]. Both, EPA and DHA supplementation was discovered to increase membrane fluidity and lipid raft clustering leading to decreased cell activation [152].…”

Section: Phospholipase a 2 Cleavage Products: Free Fatty Acidsmentioning

confidence: 99%

Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids, Polyunsaturated Fatty Acids and Eicosanoids

Knuplez

Sturm

Marsche

2021

IJMS

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Eosinophils are important effector cells involved in allergic inflammation. When stimulated, eosinophils release a variety of mediators initiating, propagating, and maintaining local inflammation. Both, the activity and concentration of secreted and cytosolic phospholipases (PLAs) are increased in allergic inflammation, promoting the cleavage of phospholipids and thus the production of reactive lipid mediators. Eosinophils express high levels of secreted phospholipase A2 compared to other leukocytes, indicating their direct involvement in the production of lipid mediators during allergic inflammation. On the other side, eosinophils have also been recognized as crucial mediators with regulatory and homeostatic roles in local immunity and repair. Thus, targeting the complex network of lipid mediators offer a unique opportunity to target the over-activation and ‘pro-inflammatory’ phenotype of eosinophils without compromising the survival and functions of tissue-resident and homeostatic eosinophils. Here we provide a comprehensive overview of the critical role of phospholipase-derived lipid mediators in modulating eosinophil activity in health and disease. We focus on lysophospholipids, polyunsaturated fatty acids, and eicosanoids with exciting new perspectives for future drug development.

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Section: Phospholipase a 2 Cleavage Products: Free Fatty Acidsmentioning

confidence: 99%

Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids, Polyunsaturated Fatty Acids and Eicosanoids

Knuplez

Sturm

Marsche

2021

IJMS

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“…The ratio of ω-3 to ω-6 PUFAs in vivo may be determined by the individual’s inflammatory status 27 , 28 . Derivatives of EPA, which is an ω-6 PUFA, are predominantly proinflammatory (prostaglandin-E2, thromboxane-A2, and leukotriene-B4), whereas metabolism of long-chain ω-3 PUFAs produces anti-inflammatory eicosanoids (e.g., resolvins and protectins), which can inhibit the production of proinflammatory mediators such as interleukin-1 (IL-1) and tumor necrosis factor (TNF-α) 29 , 30 . These mechanisms have been linked to ocular surface damage and tear film quality in individuals with DES.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Tisochrysis lutea on dry eye syndrome via NF-κB inhibition

Hong

Kim

et al. 2022

Sci Rep

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Dry eye syndrome (DES) affects the cornea, causes pain and hypersensitivity to light. Although inflammation and endoplasmic reticulum stress are known to be involved, the detailed mechanisms remain unknown. DES is characterized by a decrease in corneal thickness, tear volume, and lacrimal gland size, and damage to corneal cells. Tisochrysis lutea is a microalga that has been shown to reduce immune factors. Therefore, we hypothesized that T. lutea could ameliorate DES. We investigated the role of T. lutea in scopolamine-induced DES in BALB/c mice. Oral administration of T. lutea increased corneal thickness, tear volume, and size of the corneal cells, and reduced damage to the corneal cells. Furthermore, treatment of ARPE-19 human retinal pigmented epithelial cells with T. lutea reduced expression of the inflammatory factor, NF-κB, MAPK, and AKT. T. lutea may be used therapeutically to reduce the symptoms of DES.

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“…It seems that the role of omega-3 acids has been proven [40]. The Mediterranean diet is a widely recognized beneficial pattern of nutrition in inflammatory diseases, including RA [41,42]. Apart from omega-3 acids, the immunomodulatory effect of fiber has been demonstrated [38].…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Dysbiosis, gut-blood barrier rupture and autoimmune response in rheumatoid arthritis and schizophrenia

Maślińska¹,

Trędzbor²,

Krzystanek³

2021

Reumatologia

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The primary cause of chronic autoimmune diseases is elusive both in somatic medicine and psychiatry. Examples of such conditions are rheumatoid arthritis and schizophrenic disorders. Immune disturbances occur in both diseases, but it is difficult to combine them into a meaningful pathogenetic model. The immunological hypothesis of schizophrenia is based on non-specific changes in the cytokine system and exponents of chronic inflammation in some patients. In rheumatoid arthritis the cytokine network is much better known than in schizophrenia, and interleukin-6, tumor necrosis factor or Janus kinases became a target of treatment. Microbiome dysbiosis and disturbances of the blood-gut barrier may be a new hypothesis of the pathogenesis of somatic and psychiatric diseases. The purpose of this narrative review was to show, using the example of two chronic diseases -rheumatoid arthritis and schizophrenic disorders -that disturbances in the blood barrier of the intestine can be a common mechanism of somatic and mental disorders. The paper presents the current state of knowledge on the hypothetical relationship between microbiome dysbiosis and the pathogenesis of schizophrenia and rheumatoid arthritis. In conclusion, in the light of discoveries regarding the microbiome-gut-brain axis the immunological model of rheumatoid arthritis and schizophrenia formation may gain importance and contribute to the creation of new strategies for causal treatment of these still incurable diseases.

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The place of omega-3 and omega-6 acids in supplementary treatment of inflammatory joint diseases

Cited by 5 publications

References 57 publications

Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids, Polyunsaturated Fatty Acids and Eicosanoids

Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids, Polyunsaturated Fatty Acids and Eicosanoids

Protective effect of Tisochrysis lutea on dry eye syndrome via NF-κB inhibition

Dysbiosis, gut-blood barrier rupture and autoimmune response in rheumatoid arthritis and schizophrenia

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