The PLAN Score

Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis

“…In addition, identifying patients with poor prognosis may be beneficial for informed clinical decision making and assessing the risk-benefit ratio for acute therapies. Although several clinical scores have been proposed to predict outcome and mortality, [21][22][23] these scores are not routinely used in the clinic, in part, because of their complexity. We have shown that a simple model including only baseline mRS, primary stroke type, and MCEMP1 expression may predict 1-month disability and mortality.…”

Predicting Functional Outcome and Symptomatic Intracranial Hemorrhage in Patients With Acute Ischemic Stroke

“…It would be interesting to see whether oxygen administration would still remain an independent covariate if a comorbidity index (eg, Charlson 40 or Elixhauser indexes 41 ) was included in the model. This could possibly be also the case for other comorbidities included in some scores like cancer, 8,9 dementia, 9 renal dialysis, 9 atrial fibrillation, [8][9][10] coronary artery disease, 9,10,42 chronic heart failure, 8,9,42 diabetes mellitus, [9][10][11][12]42 hypertension, 42 smoking habit, 9 and dyslipidemia 10,43 or a more general approach of the prestroke functional status. 5,8,9 In 3 scores, 9,10,13 sex is among their constituents.…”

“…The preadmission comorbidities, level of consciousness, age, neurologic deficit (PLAN) score does not include a stroke severity score like the NIHSS or the CNS as its constituent. 8 The ASTRAL score, the DRAGON score, the iScore, the Six Simple Variables score, and the Get With The Guidelines (GWTG) score have been extensively validated in external data sets and sometimes for the prediction of outcomes other than the ones for which they were originally developed. 69,70,[82][83][84][85][86][87][88][89][90][91][92][93][94][95] These extended validations further increase the scores' reliability.…”

“…The scores that are free of specialized laboratory tests or imaging techniques and include only simple parameters are more feasible for centers with limited resources. [5][6][7][8][9][10][11][12]43 However, we cannot underestimate the additional value of imaging and laboratory parameters. The prediction score cannot be simple just for the sake of simplicity if it does not serve its purpose.…”

External Validation of the ASTRAL and DRAGON Scores for Prediction of Functional Outcome in Stroke

“…Several attempts have been made to create prognostication scores for patients with acute ischemic stroke, aiming to facilitate treatment decisions and communicate prognostic expectations to patients and families. [6][7][8][9][10][11][12][13][14] Stroke June 2016…”