The plasma ACTH, AVP, CRH and catecholamine responses to conventional and laparoscopic cholecystectomy

Donald, R. A.; Perry, Emily; Wittert, Gary; Chapman, Melissa; Livesey, J. H.; Ellis, M. J.; Evans, Margaret J.; Yandle, Timothy G.; Espiner, Eric A.

doi:10.1111/j.1365-2265.1993.tb02142.x

Cited by 105 publications

(58 citation statements)

References 34 publications

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“…This was confirmed in the present study, where urocortin was detected in the perfusate and the plasma of rats exposed to ex vivo and in vivo I/R injury, respectively. The absence of urocortin from the plasma of sham-operated rats, both before the execution of the thoracotomy and after the closure of the thoracotomy breach, suggests that neither anesthesia nor surgery alone increase circulating urocortin levels, although small but significant rises in plasma CRH have been reported in patients undergoing cholecystectomy [18].…”

Section: Discussionmentioning

confidence: 99%

Retracted: Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury

Knight¹,

Chen‐Scarabelli²,

Yuan³

et al. 2008

FEBS Letters

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This study evaluates whether cardiac ischemia induces release of urocortin, before and independently from myocyte cell death. Urocortin levels rose after 5-min ischemia and peaked after 10-min ischemia, when cell death was not detected. However, myocyte apoptosis and/or necrosis occurred following 20-and 30-min ischemia, which paralleled a fall in urocortin levels, suggesting that urocortin expression and release are mainly sustained by metabolically challenged, though still viable myocytes. Hence, since cardiac release of urocortin, unlike that of conventional biomarkers, occurs before and apart from cell death, urocortin levels may be clinically useful in the diagnosis of sublethal myocardial ischemia.

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Section: Discussionmentioning

confidence: 99%

Retracted: Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury

Knight¹,

Chen‐Scarabelli²,

Yuan³

et al. 2008

FEBS Letters

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“…The maximum ACTH and cortisol levels are reached in the early postoperative period, especially following anaesthesia reversal and endotracheal extubation (30 min after extubation) [8][9][10].…”

Section: Effect Of Anaesthesia and Surgerymentioning

confidence: 99%

“…The intactness of the HPA axis and need for steroid may be assessed by provocative tests which measure the plasma cortisol response to administration of ACTH, CRH, lysine, vasopressin, metyrapone, and insulin-induced hypoglycemia [26]. The gold standard for assessment of HPA function is the insulin tolerance test, but short synacthen test is cheaper and less unpleasant [27].…”

Section: Perioperative Steroid Replacement Therapymentioning

confidence: 99%

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Applications of Steroid in Clinical Practice: A Review

Shaikh

Verma²,

Yadav³

et al. 2012

ISRN Anesthesiology

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Steroids are perhaps one of the most widely used group of drugs in present day anaesthetic practice, sometimes with indication and sometimes without indications. Because of their diverse effects on various systems of the body, there has been renewed interest in the use of steroids in modern day anaesthetic practice. This paper focuses on the synthesis and functions of steroids and risks associated with their supplementation. This paper also highlights the recent trends, relevance, and consensus issues on the use of steroids as adjunct pharmacological agents in relation to anaesthetic practice and intensive care, along with emphasis on important clinical aspects of perioperative usefulness and supplementation.

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“…The pathophysiologic mechanisms responsible for this dramatic increase in plasma AVP in the per-operative period of major scheduled surgical procedures had not yet been fully clarified [5,24], but it can be influenced by the type [4,5,7,8,10] and invasiveness [25] of the surgical procedure, the type of employed anesthesia [24,26], and by hemodynamic [8,27] and/or serum osmolarity alterations in the per-operative period [24].…”

Section: Time Course Of Vasopressin In Our Patientsmentioning

confidence: 99%

Vasopressina plasmática em pacientes submetidos à correção de aneurisma de aorta infrarrenal

Carvalho¹,

Guillaumon²,

Cintra³

et al. 2011

Rev Bras Cir Cardiovasc

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Objectives: To evaluate plasmatic arginine vasopressin (AVP) levels in patients undergoing scheduled conventional abdominal aortic aneurysm (AAA) repair.Methods: Plasmatic AVP concentrations were measured by radioimmunoassay in 22 non-consecutive adult patients undergoing infra-renal AAA repair. They were under combined general and epidural anesthesia at the following time frames: 1 -pre-operative (T0); 2 -2h (T1) and 6h (T2) after the surgical procedure; 3 -in the morning at the first (T3), second (T4) and third (T5) post-operative days. Some clinical and laboratory variables were also recorded.Results: The mean age of patients was 68±10 years; 17 were males. Plasmatic AVP (mean±SD; pg/mL) was within the normal range at T0 (1.4±0.7; baseline), increasing significantly at T1 (62.6±62.9; P<0.001) and at T2 (31.5±49.7; P<0.001), with a progressive fall, returning to basal levels at T5 (2.1±3.8; P=NS). Positive and statistically significant correlations were found between AVP and glycemia, serum lactate and white blood cells counts, but not with systemic arterial pressure or plasma osmolarity during the postoperative period.Conclusions: Considering that no correlations were found between AVP levels and hemodynamic or plasmatic osmolarity variations in AAA repair, it seems that stress response is mainly secondary to noxious stimulation mediated by the autonomic nervous system that is not completely blocked by anesthetics. Descriptors: Intensive care units. Cardiovascular abnormalities. Receptors, vasopressin. Resumo Objetivos: Avaliar os níveis plasmáticos de vasopressina (AVP) em pacientes submetidos à correção convencional de aneurisma de aorta abdominal (AAA).Métodos: A AVP plasmática foi mensurada por radioimunoensaio em 22 pacientes não-consecutivos submetidos à correção eletiva de AAA infrarrenal sob anestesia geral + epidural nos seguintes momentos: pré-operatório (T0); 2h (T1) e 6h (T2) após a cirurgia; e nas manhãs do primeiro (T3), segundo (T4) e terceiro (T5) dia pós-operatório (PO). Variáveis clínicas e laboratoriais de interesse também foram anotadas.Resultados: A média de idade dos pacientes foi de 68±10 anos, sendo 17 homens. A AVP plasmática (média±DP; pg/ mL) estava dentro de limites normais no T0 (1,4±0,7; basal), aumentando no T1 (62,6±62,9; P<0,001) e no T2 (31,5±49,7; P<0,001), e retornando aos valores basais no T5 (2,1±3,8; RBCCV 44205-1296

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The plasma ACTH, AVP, CRH and catecholamine responses to conventional and laparoscopic cholecystectomy

Cited by 105 publications

References 34 publications

Retracted: Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury

Retracted: Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury

Applications of Steroid in Clinical Practice: A Review

Vasopressina plasmática em pacientes submetidos à correção de aneurisma de aorta infrarrenal

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