The plasma clearance of injected doses of folic acid as an index of folic acid deficiency

Metz, J.; Stevens, K.; Krawitz, S.; Brandt, Verena

doi:10.1136/jcp.14.6.622

Cited by 31 publications

(11 citation statements)

References 16 publications

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“…The rapid rise in serum folate back to the control level between hours 28 and 32 in this subject was probably caused in part by an intravenous injection of 5 mg of folic acid' at the 30th h (arrow, Fig. 1), although with a half-life of approximately 15 min for intravenously injected folic acid (14,15), the great majority of this folic acid would have been cleared from the plasma within 2 h.…”

Section: Resultsmentioning

confidence: 99%

Effect of Alcohol on Serum Folate Level

Eichner¹,

Hillman²

1973

J. Clin. Invest.

146

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Section: Resultsmentioning

confidence: 99%

Effect of Alcohol on Serum Folate Level

Eichner¹,

Hillman²

1973

J. Clin. Invest.

146

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“…One notable aspect of short-term kinetic studies involved the measurement of plasma folate clearance rate following an intravenous injection of folic acid (13,37,46,54). Chanarin et al (13) observed that the clearance rate of serum folate following folic acid injection (based on Streptococcus faecalis assays) was greater in vitamin B12-deficient megaloblastic anemia patients than in normal controls.…”

Section: Short-term Kineticsmentioning

confidence: 98%

IN VIVO KINETICS OF FOLATE METABOLISM

Gregory

Quinlivan²

2002

Annu. Rev. Nutr.

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Investigation of the in vivo kinetics of folate metabolism provides information that contributes to a better understanding of the manner in which this vitamin is processed in vivo. Kinetic studies can yield insight into the requirements for folate, especially with respect to factors that may lead to increased requirements. This review considers the strengths and weaknesses of various approaches to the study of folate kinetics and resulting data, followed by a summary and interpretation of existing data.

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“…10 Vitamin C has been shown to increase iron absorption two-to six-fold, and to prevent oxidation and excretion of folate. 13,14 In human experiments, vitamin C deficiency impaired vasoconstriction in response to adrenergic stimuli; this effect may underlie episodes of syncope, ST-segment elevation, and apparent sudden cardiac death. 15 The mechanism by which vitamin C deficiency causes other commonly described symptoms of scurvy, including fatigue, depression, and cardiovascular events, is less understood, but may reflect vitamin C's involvement in the metabolism of carnitine, corticosteroids, and neurotransmitters.…”

Section: Discussionmentioning

confidence: 99%

Petechial Rash in a Child with Autism and Trisomy 21

Sobotka¹,

Deal²,

Casper³

et al. 2014

Pediatr Ann

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A 10-year-old boy with Trisomy 21 presented to the emergency department with a history of rash on his legs, easy bruising and bleeding, and walking with a limp. One month prior to presentation, he had developed a non-pruritic, non-painful, petechial rash on his lower legs ( Figure 1). Eczema was suspected and he was treated with a topical steroid cream, but there was no improvement in the rash. Subsequently, he developed easy bruising and bleeding gums when brushing his teeth. The day prior to presentation, he began limping and then refused to walk. His parents also reported a several-month history of decreased appetite and poor weight gain. They deny any fever, night sweats, or recent illnesses.His medical history was also significant for autism, chronic constipation, and very restricted diet for the past 3 years. Over this time, his diet had been limited to peanut butter and jelly sandwiches, soy bacon, pasta, waffles, wheat porridge, cheese crackers, vanilla pudding, toaster pastries, chocolate sandwich cookies, and pretzels. He refused to eat all other foods. He was not taking any supplemental medications, vitamins, or alternative therapies. PHYSICAL EXAMINATIONOn presentation, he was noted to be a thin-appearing child who had fine, kinky hair. He was 24.5 kilograms (15 th percentile on growth curve for Trisomy 21). He had gingival swelling and bleeding around the base of several teeth, but otherwise good dentition without caries. There was blood in the left external auditory canal obscuring the left tympanic membrane; the right canal and right tympanic membrane were normal. Heart, lung, and abdominal examinations were unremarkable. His left knee was swollen without effusion or tenderness and had full range of motion; the right knee was normal. His skin was remarkable for perifollicular petechiae over bilateral lower extremities, face, and trunk, with scattered bruises over his legs. HOSPITAL COURSEHe was admitted to the hospital for further evaluation. Complete blood count, serum chemistries, liver function panel, and coagulation panel (prothrombin time, activated partial thromboplastin time, and international normalized ratio) were normal. Plain radiographs of the lower extremities were unremarkable. Additional laboratory testing confirmed the diagnosis.Editor's note: Each month, this department features a discussion of an unusual diagnosis. A description and images are presented, followed by the diagnosis and an explanation of how the diagnosis was determined. As always, your comments are welcome via email at pedann@Healio.com.

show abstract

The plasma clearance of injected doses of folic acid as an index of folic acid deficiency

Cited by 31 publications

References 16 publications

Effect of Alcohol on Serum Folate Level

Effect of Alcohol on Serum Folate Level

IN VIVO KINETICS OF FOLATE METABOLISM

Petechial Rash in a Child with Autism and Trisomy 21

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