The plasma concentration of soluble Fc‐gamma RIII is related to production of neutrophils

Huizinga, Tom W J; Haas, Masja de; Oers, Marinus H. J. van; Kleijer, Marion; Vilé, Henriette A.; Wouw, Poll A. van der; Moulijn, Adriaan C.; Weezel, Harry van; Roos, Dirk; Borne, A. E. G. K. Von Dem

doi:10.1111/j.1365-2141.1994.tb08298.x

Cited by 44 publications

(41 citation statements)

References 17 publications

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“…42 Plasma concentrations of sFc␥RIIIb have been found to correlate with the production of neutrophils and total body mass of neutrophils. 64 Finally, we confirmed previous findings regarding the influence of donor IL-1Ra (IL-1RN*2) as a protective gene polymorphism in aGVHD. 65,66 Other gene polymorphisms, such as TNF, IL-6, IL-10, and CD31, have been correlated with the risk for aGVHD.…”

Section: Discussionsupporting

confidence: 90%

Host defense and inflammatory gene polymorphisms are associated with outcomes after HLA-identical sibling bone marrow transplantation

Rocha

Franco

Porcher

et al. 2002

Blood

174

139

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We made the hypothesis that donor and recipient gene polymorphisms that drive the host response to microorganisms could be associated with infections after bone marrow transplantation (BMT). HLAidentical BMT was performed for patients with acute (n ‫؍‬ 39) or chronic leukemia (n ‫؍‬ 68). Univariate and multivariate analyses, using death as a competing event, were performed to study risk factors. In multivariate analysis, first overall infections were increased in patients with the Fc␥RIIa R-131 genotype (hazard ratio [HR] ‫؍‬ 1.92; P ‫؍‬ .04), and severe bacterial infections were increased when the MPO donor genotype was AG or AA (HR ‫؍‬ 2.16; P ‫؍‬ .03). Viral and invasive fungal infections were not influenced by any genetic factor studied. Interestingly, we also found that (1) time to neutrophil recovery was shorter when donors were Fc␥RIIIb HNA-1a/HNA-1b (HR ‫؍‬ 1.77; P ‫؍‬ .002); (2) donor IL-1Ra (absence of IL-1RN*2) increased the risk for acute graft-versus-host disease (GVHD) (II-IV) (HR ‫؍‬ 2.17; P ‫؍‬ .017); and (3) recipient IL-10 (GG) and IL-1Ra genotypes increased the risk for chronic GVHD (P ‫؍‬ .03 and P ‫؍‬ .03, respectively). Finally, 180-day transplantation-related mortality rates were increased when donors were Fc␥RIIIb HNA-1a/HNA-1a or HNA-1b/ HNA-1b (HR ‫؍‬ 2.57; P ‫؍‬ .05) and donor MPO genotype was AA (HR ‫؍‬ 5.14; P ‫؍‬ .004). In conclusion, donor and recipient gene polymorphisms are informative genetic risk factors for selecting donor/ recipient pairs and could help in the understanding of mechanisms involved in host defenses of BM transplant recipients. (Blood. 2002;100:3908-3918)

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Section: Discussionsupporting

confidence: 90%

Host defense and inflammatory gene polymorphisms are associated with outcomes after HLA-identical sibling bone marrow transplantation

Rocha

Franco

Porcher

et al. 2002

Blood

174

139

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“…Ten subjects with hepatic diseases were excluded from this study because sFcγRIIIs may be catabolized in the liver (17). Furthermore, two subjects with renal diseases also were excluded because sFcγRIIIs are excreted from the kidney (6). In support of this, we detected sFcγRIIIa Mφ , as well as total sFcγRIII, in urine at about 10% to 20% concentration of plasma levels in healthy donors (unpublished data).…”

Section: Subjectssupporting

confidence: 59%

“…It has been shown that the levels of inflammatory markers in serum, such as C-reactive protein, TNFα, and IL-6, are increased in patients with atherosclerosis (23). Because the FcγRIIIa is released from NK cells and macrophages, and FcγRIIIb is released from neutrophils on activation (4)(5)(6)(7)(8), the sFcγRIIIs in plasma also are a kind of marker for inflammation. In this study, the levels of sFcγRIIIa Mφ , but not total sFcγRIII levels, increased with the number of risk factors for atherosclerosis (see Figure 2), and no correlation between the levels of two sFcγRIIIs (Table 3) was observed in subjects with an annual medical checkup.…”

Section: Discussionmentioning

confidence: 99%

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Soluble FcγRIIIaMϕ Levels in Plasma Correlate with Carotid Maximum Intima-Media Thickness (IMT) in Subjects Undergoing an Annual Medical Checkup

Masuda

Amano

Hong

et al. 2008

Mol Med

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Macrophages play a major role in the development of vascular lesions in atherogenesis. The cells express FcγRIIIa (CD16) identical to that in NK cells, but with a cell type-specific glycosylation, and these soluble forms (sFcγRIIIa) are present in plasma. We measured sFcγRIIIa Mφ derived from macrophages in plasma from subjects undergoing an annual medical checkup. The levels of sFcγRIIIa Mφ increased with age, and correlated positively with body mass index, blood pressure, LDL cholesterol to HDL cholesterol ratio, triglycerides, hemoglobin A1c, and creatinine, but negatively with HDL-cholesterol levels. The sFcγRIIIa Mφ levels were related to the number of risk factors for atherosclerosis: such as aging, current smoking, diabetes, hypertension, hyper-LDLcholesterolemia, hypo-HDL-cholesterolemia, and family history of atherosclerotic diseases. In addition, the sFcγRIIIa Mφ levels were correlated with carotid maximum intima-media thickness (IMT). These findings indicate the macrophages are activated during the incipient stage of atherosclerosis, and suggest sFcγRIIIa Mφ may be used as a predictive marker for atherosclerosis.

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“…Endogenous IgGs can compete with IgG mAbs for binding to various classes of FcgRs, in particular with FcgRIII (15,31,32). Moreover, shedded FcgRIII can also act as a decoy element partially neutralizing the Fc part of mAbs and other IgGs (33). Finally, Her2 can also be shedded in plasma in patients with breast cancer expressing high levels of this (34).…”

Section: Discussionmentioning

confidence: 99%

Elements Related to Heterogeneity of Antibody-Dependent Cell Cytotoxicity in Patients Under Trastuzumab Therapy for Primary Operable Breast Cancer Overexpressing Her2

et al. 2007

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Preliminary results from a pilot trial on trastuzumab's mechanism of action against operable breast tumors overexpressing Her2 suggested a role for antibody-dependent cell cytotoxicity (ADCC). To examine factors affecting ADCC intensity and variability, we extended this study to the phenotypic and functional analysis of circulating mononuclear cells in 18 patients. ADCC was induced by trastuzumab therapy in 15 of 18 patients (83%). Inability to develop ADCC in three patients did not depend on inadequate levels of trastuzumab because further increase in its concentration in vitro was ineffective. Rather, susceptibility to develop ADCC was fairly predicted by test with trastuzumab before therapy and was correlated to the number of lymphocytes coexpressing CD16 and CD56. Phenotypic analysis at the end of ADCC evaluating down-regulation of CD16, and up-regulation of CD69 and CD107a, confirmed that natural killer (NK) cells and CD56 + T cells were involved in productive engagement of trastuzumab. Also, the killing efficiency of CD16 + lymphocytes was influenced by 158 V/F polymorphism of Fc;RIII (CD16), whereas variations of CD247 on NK cells were consistent with trends between ADCC before and after therapy. Complete pathologic response was observed in one patient showing ADCC of outstanding intensity, whereas four cases of partial response showed intermediate ADCC; none of the three patients unable to mount ADCC had significant tumor regression. These data indicate that quantity and lytic efficiency of CD16 + lymphocytes are major factors for ADCC induction by trastuzumab, and confirm that breast cancer responses to short-term trastuzumab monotherapy may depend on involvement of the ADCC mechanism. [Cancer Res 2007;67(24):11991-9]

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The plasma concentration of soluble Fc‐gamma RIII is related to production of neutrophils

Cited by 44 publications

References 17 publications

Host defense and inflammatory gene polymorphisms are associated with outcomes after HLA-identical sibling bone marrow transplantation

Host defense and inflammatory gene polymorphisms are associated with outcomes after HLA-identical sibling bone marrow transplantation

Soluble FcγRIIIaMϕ Levels in Plasma Correlate with Carotid Maximum Intima-Media Thickness (IMT) in Subjects Undergoing an Annual Medical Checkup

Elements Related to Heterogeneity of Antibody-Dependent Cell Cytotoxicity in Patients Under Trastuzumab Therapy for Primary Operable Breast Cancer Overexpressing Her2

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