The plasma glucose lowering action of Hei-Shug-Pian, the fire-processed product of the root of Aconitum (Aconitum carmichaeli), in streptozotocin-induced diabetic rats

Evaluation of Hypoglycemic Activity and Toxicity Profiles of the Leaves of Ficus deltoidea in Rodents

“…Apparently, the administration of lower or higher doses of methanol as well as hexane, chloroform, butanol and aqueous residual extracts gave rise to only transient blood glucose lowering responses. The effective dose of extracts derived from F. deltoidea was relatively narrow when compared to other antidiabetic plants (Andrade-Cetto and Wiedenfeld, 2004;Liou et al, 2006). 2.29 ± 0.65 (-34.32 ± 11.33) * 1.92 ± 0.58 (-44.55 ± 8.55) * * p < 0.05 in relation to control.…”

“…Nonetheless, a number of plants have shown a low margin of safety (LD 50 < 350 mg/kg body weight of animal model) in accordance to Hodge and Sterner scale of toxicity (Hodge and Sterner, 1956) and also various adverse reactions in spite of having substantial potential as hypoglycemic agents (Arena and Drew, 1980;Goldfain et al, 1989;AbdelHassan et al, 2000;Alarcon-Aguilar et al, 2002;Maroo et al, 2003;Nagappa et al, 2003;Liou et al, 2006;Ojewole, 2006). The treatment of diabetes is aggravated by the fact that the existing hypoglycemic agents are expensive and may develop adverse reactions upon consumption (Chakrabati et al, 2005;Sangameswaran and Jayakar, 2007).…”

Prescription Pattern of Chinese Herbal Products for Diabetes Mellitus in Taiwan: A Population-Based Study

“…Previous studies of traditional Chinese medicines have found that tianhuafen (Radix Trichosanthis) [16] , gegen (Radix Puerariae) [17], maimendong (Radix Ophiopogonis) [18], rougui (Cortex Cinnamomi) [19, 20], huangbai (Cortex Phellodendri) [21] and aconitum (Aconitum carmichaeli) [22] may have antidiabetic activity, and dihuang (Radix Rehmanniae) [23] , shanzhuyu (Fructus Corni) [24], renshen (Radix Ginseng) [25], gancao (Radix Glycyrrhizae Praeparata) [26], and bitter orange (Aurantii Fructus) [27] have been suggested to increase insulin secretion. Unfortunately, evidence obtained in human studies is limited regarding patterns of use of classical traditional Chinese medicine (TCM) in relation to type 2 diabetes, which seem to be an area in which complementary and alternative medicines have recently grown in popularity.…”

Chemical and biological studies of Aconitum pharmaceutical resources

“…Heterophyllinine A and heterophyllinine B of A. heterophyllum are selective butyrylcholinesterase inhibitors (Nisar et al, 2009). Heishunpian, the fire-processed product of the root of A. carmichaeli, lowers the plasma glucose concentrations of streptozotocin-induced diabetic rats through activation of opioid mu-receptors of peripheral tissues, resulting in enhanced glucose utilization (Liou et al, 2006). The significant hypolipidemic effect of A. heterophyllum may be linked to its ability to inhibit HMGR activity and block intestinal fat absorption (Subash and Augustine, 2012).…”