The Plasma Kinin-Forming System

Spragg, Jocelyn

doi:10.1007/978-1-4684-0745-7_4

Cited by 5 publications

(1 citation statement)

References 92 publications

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“…During prooestrus, when kininogens decline, the threshold was around 3.75 ng/ml. This compares with values of <3 -5 ± 2 ng/ml in normal plasma (Spragg 1974;Pisano 1975), and 20-25 ng/ml when the kinin system is activated in pathological conditions (Eisen 1970). Before ovulation, which has many similarities to inflammation (Smith & Perks 1983a), plasma levels could become highly increased, since 41 -79% of the circulating precursors are depleted from the blood (Smith & Perks 1979).…”

Section: Discussionsupporting

confidence: 60%

The effects of bradykinin on the contractile activity of the isolated rat ovary

Smith¹,

Perks²

1984

Acta Endocrinologica

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Studies of ovarian contractility were carried out on 43 rat ovaries maintained in vitro. Eighteen ovaries showed spontaneous motility. In 65 of 155 tests (42%), synthetic bradykinin (3.75\p=n-\25.0 ng/ml saline) produced sustained increases in ovarian tone, or stimulated phasic contractions. Failure to respond was related to the stage of the oestrous cycle. Sensitivity was highest around ovulation (00.00\p=n-\04.00 h oestrus), when there were 25 responses in 26 tests, and the linear relationship between the response and the logarithm of the concentration suggested a threshod of 2.9 ng/ml saline. Sensitivity fell later in oestrus, and reached its lowest point in metoestrus (1 reponse in 20 tests). Since the plasma kinin system is activated before ovulation, and the threshold to bradykinin was within reported plasma kinin levels, it seems possible that plasma kinins are involved in contractile processes associated with ovulation.

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Section: Discussionsupporting

confidence: 60%