The plasma levels of hsa-miR-19b-3p, hsa-miR-125b-5p and hsa-miR-155b-5p in NSCLC patients

Bulgakova, Olga; Kussainova, Assiya; Kalibekov, N.; Serikbaiuly, Dulat; Zinoveva, T.; Aripova, Akmaral; Bersimbaev, R. I.

doi:10.26577/ijbch-2019-v2-10

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“…The level of freecirculating microRNA hsa-miR-19b-3p was significantly higher in groups of patients with lung cancer compared with healthy individuals. Our results indicate that the detection of hsa-miR-19b-3p levels in blood plasma can potentially be used as a non-invasive method for diagnosing lung cancer [58] and further identification of miRNAs as a specific marker of radon exposure becomes very relevant. However, a major disadvantage of this approach is the low specificity of the method based on freecirculating miRNAs and the inability to obtain miRNAsdirectly from tumor tissue.…”

Section: Role Of Exosomal Microrna In Diagnosis Of Lung Cancermentioning

confidence: 92%

Exosomes and the role of exosomal miRNA in the diagnosis of lung cancer

Bersimbaev¹,

Bulgakova²,

Aripova³

et al. 2021

bulbioenu

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Exosomes are extracellular vesicles secreted by almost all cell types that can function as a cell-to-cell carrier of information, providing pleiotropic functions in intercellular communication. Exosomes can transport various biomolecules, including proteins and nucleic acids, into recipient cells. The review analyzed the current data on the role of exosomes and the possibility of using exosomal microRNAs as a biomarker in the diagnosis of lung cancer. MicroRNAs can act as oncogenes or tumor suppressors, so they can regulate the expression of genes that play an important role in oncogenesis. At the moment, microRNAs of exosomes are one of the main candidates for the role of molecular markers in liquid biopsy for the diagnosis of oncological diseases. The review analyzes the diagnostic potential of the use of exosomes in carcinogenesis in general, with an emphasis on the use of exosomal microRNAs as biomarkers of lung cancer.

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Section: Role Of Exosomal Microrna In Diagnosis Of Lung Cancermentioning

confidence: 92%