The Plasmepsin Family as Antimalarial Drug Targets

Ruben, Adam J.; Kiso, Yoshiaki; Freire, Ernesto

doi:10.1002/9783527630943.ch18

Cited by 2 publications

(1 citation statement)

References 161 publications

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“…KNI-10006 for example is very potent against plasmepsin II but has only poor influence on parasite growth. In contrast, compound KNI-10283, which does not contain a basic amine, has been tested for in vivo efficacy in the P. berghei -infected mouse model revealing an expanded increase in lifespan of mice of up to 170% [25, 111, 112]. These results support the development of broad-spectrum plasmepsin inhibitors as antimalarial agents.…”

Section: Interfering With Proteins Trafficked To the Food Vacuolementioning

confidence: 99%

Trafficked Proteins—Druggable inPlasmodium falciparum?

Lindner

Meissner

Schettert³

et al. 2013

International Journal of Cell Biology

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Malaria is an infectious disease that results in serious health problems in the countries in which it is endemic. Annually this parasitic disease leads to more than half a million deaths; most of these are children in Africa. An effective vaccine is not available, and the treatment of the disease is solely dependent on chemotherapy. However, drug resistance is spreading, and the identification of new drug targets as well as the development of new antimalarials is urgently required. Attention has been drawn to a variety of essential plasmodial proteins, which are targeted to intra- or extracellular destinations, such as the digestive vacuole, the apicoplast, or into the host cell. Interfering with the action or the transport of these proteins will impede proliferation of the parasite. In this mini review, we will shed light on the present discovery of chemotherapeutics and potential drug targets involved in protein trafficking processes in the malaria parasite.

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Section: Interfering With Proteins Trafficked To the Food Vacuolementioning

confidence: 99%