The pleiotropic role of interleukin-17 in atherosclerosis

Allam, Gamal; Abdel-Moneim, Adel; Gaber, Asmaa

doi:10.1016/j.biopha.2018.07.110

Cited by 36 publications

(35 citation statements)

References 118 publications

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“…The role of IL‐17 in atherosclerosis is debatable, as it may have a proatherogenic or atheroprotective effect . It is suggested that the potential pathogenic or protective effects of Th17 cells, which produce IL‐17, depends on the different environmental cues .…”

Section: Discussionmentioning

confidence: 99%

Effect of biologics targeting interleukin‐23/‐17 axis on subclinical atherosclerosis: results of a pilot study

et al. 2020

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Summary Background Psoriasis is associated with an increased risk of developing atherosclerotic vascular disease. The hypothesis that treatment of the skin inflammation may decrease the risk of developing atherosclerosis and consequently, cardiovascular disease, is currently a focus of significant attention. Aim To assess the effect of biologic drugs targeting the interleukin (IL)‐23/IL‐17 axis on selected subclinical atherosclerosis parameters in patients with psoriatic disease. Methods In a series of patients with moderate to severe psoriasis who were eligible for biologic therapy, pulse wave velocity (PWV) and intima–media thickness (IMT) were determined before therapy and after 6 months of treatment with biologics (ustekinumab, secukinumab, ixekizumab). Results After 6 months of treatment, a marked clinical improvement of skin lesions was observed in all patients. No significant changes in PWV or IMT values were observed before (8.59 ± 1.96 mm and 0.54 ± 0.9 mm, respectively) and after 6 months (8.89 ± 2.02 mm and 0.53 ± 0.9 mm) of therapy (P = 0.16 and P = 0.74). Conclusions Systemic treatment of patients with a psoriatic disease with biologics targeting the IL‐23/IL‐17 axis has a possibly neutral effect on atherosclerosis. Additional studies are needed to assess the impact of newer biologic treatments on atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Effect of biologics targeting interleukin‐23/‐17 axis on subclinical atherosclerosis: results of a pilot study

et al. 2020

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“…AGE-RAGE signaling pathway can not only cause glycolipid metabolism disorder and oxidative stress enhancement, but also induce MAPK, JAK-STAT and PI3K Akt signaling pathway to promote in ammation and promote the development of diabetes [46] ,Previous studies also found that regulating AGE-RAGE signaling pathway can alleviate oxidative stress in prefrontal cortex and hippocampus of depressed rats and improve stroke symptoms [47] ,It has been reported that DCHD can reduce the content of oxygen free radicals (such as no, Co, MDA) and improve the level of SOD [48] .It is also con rmed that Th17 and IL-17 signaling pathway affect diabetes mellitus and acute hemorrhagic stroke by regulating immune in ammatory response. [49][50][51][52] It is also proved that DCHD can reduce the levels of hs CRP, IL-6 and TNF -α in serum, and reduce the damage of in ammatory factors to the focus and surrounding cells. [53,54] The common signaling pathways regulating immune and in ammatory responses in PD and AHS also include EGFR tyrosine kinase inhibitor resistance, TNF, PI3K Akt, toll like receptor, MAPK, JAK stat, cytokine cytokine receptor interaction and other signaling pathways [55][56][57][58][59][60] .HIF-1 signaling pathway has cell-speci c response to vascular endothelial cells, smooth muscle cells and macrophages.…”

Section: Discussionmentioning

confidence: 99%

Study on The Effect Mechanism of “Common Treatment for Different Diseases” of Dachaihu Decoction on Prediabetes and Acute Hemorrhagic Stroke Based on Network Pharmacology

Zhang¹,

Cao²,

Zhang³

et al. 2020

Preprint

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Background: In this study, network pharmacology method was used to systematically predict and analyze the mechanism of "Common treatment for different diseases" effect of Dachaihu Decoction(DCHD) in the treatment of Prediabetes(PD) and Acute hemorrhagic stroke(AHS).Methods: TCMsp (Traditional Chinese Medicine systems pharmacology database and analysis platform) database was used to collect all the candidate active components related to 8 kinds of traditional Chinese medicine of DCHD, and UniProt database was used to obtain the drug action target and construct the "traditional Chinese medicine -Compound -target" action network; Genecards, OMIM(Online Mendelian Inheritance in Man), DisGeNET, CTD(Comparative Toxicogenomics Database) and TTD（Therapeutic Target Database）databases were used to obtain the related genes of PD and AHS respectively, and the interaction analysis of Venn with potential active components was carried out to obtain the common target of DCHD in the treatment of the two diseases.Using STRING 11.0 and Cytoscape3.72 to analyze protein-protein interaction of common targets and screen key common targets. BioGPS was used to obtain the distribution information in organs and tissues, and the relationship between the molecules and the key functional molecules were described. Bioconductor (R) was used to analyze the gene ontology (go) enrichment and the pathway analysis of the Kyoto Encyclopedia of genes and genomes (KEGG), so as to systematically predict the mechanism of "Common treatment for different diseases" of DCHD for PD and AHS.Results: with OB ≥ 30% and DL ≥ 0.18 as the screening criteria, 133 active compounds were screened out and 1034 drug targets were obtained; There are 3878 PD gene targets, 2674 AHS gene targets, 129 drug disease common targets, and 10 key targets whose median value is greater than 18;The key common targets displayed by biogps are mainly distributed in CD33+_ Myeloid.2(degree = 4)，Prostate.2(degree = 3)，CD56+_ NKCells.1(degree = 3)，Lung.2(degree = 3)，CD56+_ Nkcells. 2 (degree = 2);2281 biological processes, 65 cell components and 142 molecular functions were obtained by GO functional enrichment analysis;161 signal pathways were obtained by KEGG enrichment analysis, and the ones with higher proportion were AGE-RAGE signaling pathway in diabetic complications,PI3K-Akt signaling pathway,TNF signaling pathway,IL-17 signaling pathway,MAPK signaling pathway,HIF-1 signaling pathway,Relaxin signaling pathwa,C-type lectin receptor signaling pathway,which is mainly related to oxidative stress, glycolipid metabolism, immune inflammatory response, and neuroendocrine.Conclusion: DCHD can achieve the effect of "Common treatment for different diseases" by acting on the common receptor of PD and AHS through multi-component, multi-target and multi-channel, providing reference for further experimental verification, potential pharmacological mechanism and clinical application.

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“…Intriguingly, this cytokine has also been implicated in the pathobiology of vascular disease. 27 IL-17A is produced by Th17 cells, which represent a subpopulation of the CD4 þ T-helper cells. It is believed that IL-17A can serve as an upstream stimulus for key atherogenic cytokines such as IL-1b, IL-6, tumour necrosis factor a, and nuclear factor-kB activator 1.…”

mentioning

confidence: 99%

“…It is believed that IL-17A can serve as an upstream stimulus for key atherogenic cytokines such as IL-1b, IL-6, tumour necrosis factor a, and nuclear factor-kB activator 1. 27 In this issue of the Journal, Makavos et al report the results of a study evaluating the impact of IL-17A inhibition (with the use of secukinumab) on measures of cardiovascular function in patients with psoriasis. 28 The authors studied 150 patients with psoriasis who were treated with either secukinumab, cyclosporine, or methotrexate over a 12-month period.…”

mentioning

confidence: 99%

Does Interleukin-17A Blockade Have a Potential Clinical Role to Reduce Cardiovascular Risk in Psoriasis?

Verma

Bhatt

2020

Canadian Journal of Cardiology

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The pleiotropic role of interleukin-17 in atherosclerosis

Cited by 36 publications

References 118 publications

Effect of biologics targeting interleukin‐23/‐17 axis on subclinical atherosclerosis: results of a pilot study

Effect of biologics targeting interleukin‐23/‐17 axis on subclinical atherosclerosis: results of a pilot study

Study on The Effect Mechanism of “Common Treatment for Different Diseases” of Dachaihu Decoction on Prediabetes and Acute Hemorrhagic Stroke Based on Network Pharmacology

Does Interleukin-17A Blockade Have a Potential Clinical Role to Reduce Cardiovascular Risk in Psoriasis?

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