The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma

Montico, Barbara; Giurato, Giorgio; Pecoraro, Giovanni; Salvati, Annamaria; Covre, Alessia; Colizzi, Francesca; Steffan, Agostino; Weisz, Alessandro; Maio, Michele; Sigalotti, Luca; Fratta, Elisabetta

doi:10.1002/1878-0261.13034

Cited by 16 publications

(13 citation statements)

References 230 publications

(229 reference statements)

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“…Yet, advanced melanoma is still a life‐threatening disease 16 . CircRNAs are part of the drivers of melanoma progression 17 . For instance, CDR1as acts as a key player in melanoma metastasis via IGF2BP3 18 .…”

Section: Discussionmentioning

confidence: 99%

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circITCH suppresses cell proliferation and metastasis through miR‐660/TFCP2 pathway in melanoma

et al. 2022

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Background Melanoma is an aggressive disease that is rising in incidence. Advanced melanoma is still a life‐threatening disease. CircRNAs are documented to be involved in melanoma progression. But circITCH role in melanoma remains unclear. Methods and Results To explore the functions of circITCH in melanoma, levels of circITCH in melanoma tissues and paracarcinoma normal tissues were detected. To study the roles of circITCH in melanoma in terms of cell proliferation and migration, in vitro and in vivo experiments were performed. Mechanism study was designed to investigate the potential regulatory effect of circITCH in melanoma. Results revealed that circITCH expression was repressed in melanoma versus adjacent normal tissues. Function study showed that circITCH suppressed melanoma cell proliferation and metastasis. The mechanism study showed that circITCH‐sponged miR‐660 to upregulate TFCP2 and suppress melanoma progression. Conclusions The circITCH/miR‐660/TFCP2 axis is involved in melanoma progression hence circITCH can be a diagnostic biomarker as well as a target for treating melanoma.

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Section: Discussionmentioning

confidence: 99%

“… 16 CircRNAs are part of the drivers of melanoma progression. 17 For instance, CDR1as acts as a key player in melanoma metastasis via IGF2BP3. 18 And circ_0020710 promotes melanoma progression and immune evasion through the miR‐370‐3p/CXCL12 axis, 19 indicating the importance of circRNAs in melanoma.…”

Section: Discussionmentioning

confidence: 99%

circITCH suppresses cell proliferation and metastasis through miR‐660/TFCP2 pathway in melanoma

et al. 2022

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“…The level of macrometastasis was reduced in the liver of anti -miR-182-treated animals, highlighting the pro-oncogenic and prometastatic role of miR-182 [ 33 ]. However, several limitations of miRNA-based therapy within clinical applications remain, including a lack of efficient delivery into the cells, pleiotropic functioning of miRNAs and rapid plasma degradation [ [34] , [35] , [36] ].…”

Section: Discussionmentioning

confidence: 99%

miR-204-5p in vivo inhibition cause diminished CD45RO cells rate in lungs of melanoma B16-bearing mice

Palkina

Aksenenko

Zemtsov

et al. 2022

Non-coding RNA Research

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“…CircRNAs have been found to interact with miR-NAs and create a network to control cellular physiological and pathological functions in several scenarios [19]. In melanoma, several circRNAs such as CDR1-AS [20] , circ_0002770 [21] circRNA_0084043 [22,23], circ_0025039 [24], circ-MYC [25], circ_0079593 [26], circ-FOXM1 [27], circ_0020710 [28] work as miRNA sponges or interact with RBPs to modulate the expression level of target miRNAs or proteins, which in turn affects various cellular signaling cascades and cancer-related cellular transitions [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

“…An increasing amount of data suggests that LncRNAs have a variety of roles in cellular activities notwithstanding that they are not translated into proteins. LncRNA can interact to control gene expression by altering local chromatin structure or recruiting regulatory molecules to particular locations [30]. While the interactions with proteins can either promote or inhibit protein complexes formation, the interactions with mRNAs can be more intricate and alter their stability, translation, and isolation [32].…”

Section: Introductionmentioning

confidence: 99%

Association of Circular RNA and Long Noncoding RNA Dysregulation to Clinical Response to Immunotherapy in Cutaneous Metastatic Melanoma

Oliver¹,

Onieva²,

Garrido-Barros³

et al. 2022

Preprint

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Cutaneous Melanoma (CM) is the most lethal form of skin cancer if it becomes metastatic, where treatment options and survival chances decrease dramatically. Immunotherapy treatments based on the immunologic checkpoint inhibitors (PD-1 and CTLA4) constituted a main breakthrough in the treatment of metastatic CM, particularly in the long-term benefit. However, several molecular pathways are responsible for the failure of this strategy in about 50-70% of CM patients. Some Long Non-coding RNAs (lncRNAs), and circular RNAs (circRNA) are implicated in triggering pro- and antitumorigenic responses to various cancer treatments. The relationship between lncRNA, circRNA and Immune Checkpoint Blockade (ICB) immunotherapy is not extensively explored in cutaneous metastatic melanoma (CMM). The aim of this study is to evaluate the potential role of both circRNA and lncRNA as a predictive immunotherapy biomarker in CMM. RNA-seq from 12 FFPE samples from the metastatic biopsy of metastatic melanoma patients treated with Nivolumab were analyzed. Our findings indicate that specific lncRNA and circRNA are involved in regulatory networks of the immune response against metastatic melanoma under treatment with nivolumab. Moreover, we have established a risk score that allows the prediction of Overall survival (OS) and Progression-free survival (PFS) of CMM patients with high accuracy. This proof of principle work provides a possible insight on the function of ceRNA, contributing to decipher the complex molecular mechanism of ICB cancer treatment response.

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The pleiotropic roles of circular and long noncoding RNAs in cutaneous melanoma

Abstract: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

Cited by 16 publications

References 230 publications

circITCH suppresses cell proliferation and metastasis through miR‐660/TFCP2 pathway in melanoma

circITCH suppresses cell proliferation and metastasis through miR‐660/TFCP2 pathway in melanoma

miR-204-5p in vivo inhibition cause diminished CD45RO cells rate in lungs of melanoma B16-bearing mice

Association of Circular RNA and Long Noncoding RNA Dysregulation to Clinical Response to Immunotherapy in Cutaneous Metastatic Melanoma

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