The politics of germline therapy

Bonnicksen, Andrea L.

doi:10.1038/ng0598-10

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Does Modification Of the Mtdna Violate A Child's Right To An Open Future?1

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Cited by 5 publications

(2 citation statements)

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“…Modifications in the mtDNA may also influence nuclear gene expression. What does it mean to alter the match between nuclear and mitochondrial complements (Bonnicksen, 1998)? The ethical assessment of germ-line modification (in the context of mtDNA disorders) should therefore also reflect on the significance of the distinction between nuclear DNA and mtDNA.…”

Section: Conceptual Issuesmentioning

confidence: 99%

Ooplasmic and nuclear transfer to prevent mitochondrial DNA disorders: conceptual and normative issues

Bredenoord

Pennings

Wert

2008

Human Reproduction Update

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Section: Conceptual Issuesmentioning

confidence: 99%

Ooplasmic and nuclear transfer to prevent mitochondrial DNA disorders: conceptual and normative issues

Bredenoord

Pennings

Wert

2008

Human Reproduction Update

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“…Other authors have remarked that mitochondria may have a significant but unknown biological function other than energy production (Nagao et al, 1998). In fact, little is known about the exact role and function of the mtDNA (Thornburn et al, 2001) and little is known about the significance of altering the match between nuclear and mitochondrial complements (Bonnicksen, 1998;Bowles et al, 2007;St John et al, 2004;Poulton et al, 2006). Although perhaps hypothetical, the mtDNA may influence nuclear gene expression and this, in turn, may influence essential characteristics of the resulting child (Szebik, 1999;Parens and Juengst, 2001).…”

Section: Does Modification Of the Mtdna Violate A Child's Right To An Open Future?mentioning

confidence: 99%

Ethics at the interface of reproductive medicine and genetic technology : the case of mitochondrial disorders

Bredenoord¹

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