This article studies the influence of the antineoliberal social movements in Peru and Ecuador in the face of the Multiparty Trade Agreement (MTA) between both countries and the European Union (EU). To identify and analyze this influence, a transdisciplinary theoretical framework was created, integrating debates and concepts from social movement theory and critical international political economy. In Peru, the movement used European allies to establish their demands on the EU’s agenda, which resulted in increased pressure on the government to enforce labor rights and environmental standards. In Ecuador, the movement was able to establish food sovereignty and the rejection of free trade in the national constitution. As a result, the negotiations with the EU were delayed and Ecuador achieved certain exceptions in its adhesion protocol. Nevertheless, both movements were unable to maintain their influence, due to political and socioeconomic dynamics on the domestic and global levels.