This paper explores how a global health crisis affects the causes and consequences of social movements. Drawing on media coverage, press releases, emails, and other available primary data sources, we examine how the pandemic changed the opportunities and conditions for activists on the right and left and those they challenge. We begin by considering the nature of the COVID-19 pandemic and the concomitant government response, which alters the structure of political opportunities activists face. We then look at the development of a range of protest campaigns that have emerged in response, assessing changes in opportunities for activists to reach and mobilize target constituencies, the construction of grievances, nature of alliances, as well as innovation in tactics and organization. Finally, we consider the potential outcomes of these protests during the pandemic and extending afterward.