The paper considers the notion of Science Policy from a postcolonial perspective. It examines the theoretical implications of the recent trend to include emerging and developing countries in international Science Policies by way of the case study of Switzerland. This country’s new international science policy instruments and measures have challenged the classical distinction between international scientific cooperation and development cooperation, with consequences on standards and evaluation criteria. The analysis reveals that the underlying assumptions of the concept of Science Policy perpetuate traditional asymmetries in the global political economy of science. The paper suggests that the present legacy of Science Policy institutions and practices needs to be transformed to reflect an increasingly diverse spectrum of scientific purposes and traditions. It offers a revised set of foundational assumptions on Science Policy and, more broadly, proposes a fresh point of entry for the field of Science & Technology Studies (STS) to contribute to the Science Policy discourse.