Abstract:The results show that the pollen extract in Femal does not give the preparation any estrogenic effect. Thus, Femal, which has proven clinical efficacy, is a nonestrogenic alternative to hormone therapy in women with menopausal symptoms.
“…The results show the higher amount of this isoflavone in the extracts of PanserinaUniSa and PanserinaUniVie as well as in the commercial product 2, thus confirming the similarities between these three samples already deduced from PCA analysis. Since genistein is considered as an active compound in estrogenic therapy (Ferrante et al 2004; Hellstrom and Muntzing 2012), our results highlight that genistein intake may change depending on the origin of different commercial products, thereby having different effects on the treatment of PMS.Fig. 5Relative quantitative analysis of genistein in the commercial products (# 1, 2, 3, 4, 5) and in the hydroaloholic extracts PanserinaUnisa and UniVie.…”
Potentilla anserina L. (Rosaceae) is known for its beneficial effects of prevention of pre-menstrual syndrome (PMS). For this reason P. anserina is processed into many food supplements and pharmaceutical preparations. Here we analyzed hydroalcoholic reference extracts and compared them with various extracts of different pharmacies using an integrative metabolomics platform comprising GC-MS and LC-MS analysis and software toolboxes for data alignment (MetMAX Beta 1.0) and multivariate statistical analysis (COVAIN 1.0). Multivariate statistics of the integrated GC-MS and LC-MS data showed strong differences between the different plant extract formulations. Different groups of compounds such as chlorogenic acid, kaempferol 3-O-rutinoside, acacetin 7-O-rutinoside, and genistein were reported for the first time in this species. The typical fragmentation pathway of the isoflavone genistein confirmed the identification of this active compound that was present with different abundances in all the extracts analyzed. As a result we have revealed that different extraction procedures from different vendors produce different chemical compositions, e.g. different genistein concentrations. Consequently, the treatment may have different effects. The integrative metabolomics platform provides the highest resolution of the phytochemical composition and a mean to define subtle differences in plant extract formulations.Electronic supplementary materialThe online version of this article (doi:10.1007/s11306-012-0473-x) contains supplementary material, which is available to authorized users.
“…The results show the higher amount of this isoflavone in the extracts of PanserinaUniSa and PanserinaUniVie as well as in the commercial product 2, thus confirming the similarities between these three samples already deduced from PCA analysis. Since genistein is considered as an active compound in estrogenic therapy (Ferrante et al 2004; Hellstrom and Muntzing 2012), our results highlight that genistein intake may change depending on the origin of different commercial products, thereby having different effects on the treatment of PMS.Fig. 5Relative quantitative analysis of genistein in the commercial products (# 1, 2, 3, 4, 5) and in the hydroaloholic extracts PanserinaUnisa and UniVie.…”
Potentilla anserina L. (Rosaceae) is known for its beneficial effects of prevention of pre-menstrual syndrome (PMS). For this reason P. anserina is processed into many food supplements and pharmaceutical preparations. Here we analyzed hydroalcoholic reference extracts and compared them with various extracts of different pharmacies using an integrative metabolomics platform comprising GC-MS and LC-MS analysis and software toolboxes for data alignment (MetMAX Beta 1.0) and multivariate statistical analysis (COVAIN 1.0). Multivariate statistics of the integrated GC-MS and LC-MS data showed strong differences between the different plant extract formulations. Different groups of compounds such as chlorogenic acid, kaempferol 3-O-rutinoside, acacetin 7-O-rutinoside, and genistein were reported for the first time in this species. The typical fragmentation pathway of the isoflavone genistein confirmed the identification of this active compound that was present with different abundances in all the extracts analyzed. As a result we have revealed that different extraction procedures from different vendors produce different chemical compositions, e.g. different genistein concentrations. Consequently, the treatment may have different effects. The integrative metabolomics platform provides the highest resolution of the phytochemical composition and a mean to define subtle differences in plant extract formulations.Electronic supplementary materialThe online version of this article (doi:10.1007/s11306-012-0473-x) contains supplementary material, which is available to authorized users.
“…Compared with ethinyl estradiol, PureCyTonin V R did not show any uterotrophic effect in immature female rats when the uterotrophic screening assay was applied in juvenile Wistar rats [16]. No estrogenic effect was demonstrated in a reporter gene assay using human embryonic kidney 293T cells that were co-transfected with estrogen receptors ER alpha and ER beta and a luciferase reporter plasmid containing ER response elements.…”
Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones. This review focuses on one such non-hormonal option, namely, purified and specific cytoplasmic pollen extract, or PureCyTonin V R. This extract has been evaluated in several preclinical and clinical studies, where it demonstrated its value as a safe and non-estrogenic alternative for menopause. This review presents the beneficial effects of PureCyTonin V R in the treatment of menopausal symptoms (e.g. hot flushes) in healthy women, as well as in premenstrual syndrome. We discuss the mechanism of action of PureCyTonin V R , an SSRI-'like' therapy. The lack of estrogenic effect demonstrated in preclinical studies suggests that PureCyTonin V R may also be a suitable option for the management of menopausal symptoms in women with breast cancer.
“…Hellström and Muntzing [ 9 ] published a study in which they used chromatography to determine the composition of PI 82-GC FEM with respect to presence of phytoestrogenic substances. Additionally, the oestrogenic effect of these extracts was assessed by an uterotrophic assay in an animal model.…”
Over 30% of women suffering from menopausal symptoms use products of plant origin. This paper presents the results of a study devoted to evaluation of the efficacy of the Femelis Meno dietary supplement containing standardized flower pollen and pistil extracts (PI 82-GC FEM).
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