The polymorph and crystal habit control of dl-methionine assisted by ultrasound

Li, Zhixu; Ma, Yiming; Lin, Jiawei; Gao, Zhenjie; Wu, Songgu; Li, Wei; Han, Dandan; Gong, Junbo; Wang, Jingkang

doi:10.1016/j.jcrysgro.2022.126818

Cited by 12 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…69 After nearly 100 years of development, the ultrasound field has been widely used in the optimization of crystal products, such as to improve the purity, particle size, and uniformity of crystals; shorten the crystallization time; control the crystal habit; produce the desired polymorph of API; and so on. 70 It is reported that the capability of ultrasound to regulate polymorphs mainly derived from the ultrasonic cavitation activity, as shown in Figure 26. 71 One of the most comparative advantages of ultrasound is the the unstable form β selectively crystallized under ultrasonic irradiation, while the metastable form α was selectively crystallized without ultrasonic irradiation.…”

Section: Ultrasoundmentioning

confidence: 99%

“…The application of ultrasound in crystallization can date back to 1927 . After nearly 100 years of development, the ultrasound field has been widely used in the optimization of crystal products, such as to improve the purity, particle size, and uniformity of crystals; shorten the crystallization time; control the crystal habit; produce the desired polymorph of API; and so on . It is reported that the capability of ultrasound to regulate polymorphs mainly derived from the ultrasonic cavitation activity, as shown in Figure .…”

Section: Novel Techniques For Preparation and Regulation Of Drug Poly...mentioning

confidence: 99%

See 1 more Smart Citation

An Overview on Polymorph Preparation Methods of Active Pharmaceutical Ingredients

Zhou,

Lv,

Liu

et al. 2023

Crystal Growth & Design

View full text Add to dashboard Cite

Polymorphism, which plays an important role in the pharmaceutical industry, is quite common for active pharmaceutical ingredients (API). Owing to the structural differences between polymorphs, they often possess remarkably different physical and chemical properties, thus leading to diversity in curative effects and shelf life. How to precisely control the polymorph of API has attracted the attention of researchers around the world. In this paper, the regulation methods of drug polymorphs are comprehensively reviewed, to give a better view for the future research. The traditional method, including the control of the nucleation and growth process, is systematically introduced and analyzed from the aspects of the action mechanism and their application in recent years. In addition, novel techniques, including templates, microfluidics technology, ultrasound, laser, ionic liquids, and supramolecular gels, are expounded and analyzed in detail. Considerable studies indicate that polymorph control of API is a promising research field. Finally, the existing problems are discussed and the future prospects are given.

show abstract

Section: Ultrasoundmentioning

confidence: 99%

Section: Novel Techniques For Preparation and Regulation Of Drug Poly...mentioning

confidence: 99%

An Overview on Polymorph Preparation Methods of Active Pharmaceutical Ingredients

Zhou,

Lv,

Liu

et al. 2023

Crystal Growth & Design

View full text Add to dashboard Cite

show abstract

“…Generally, the crystal morphology depends on the relative growth rates of different crystal surfaces. The faster the growth in a given direction, the lower the morphological importance. , It has been found that process conditions, such as cooling rate and stirring rate, have very limited abilities to engineer the crystal morphology. − In particular, some crystals have strong hydrogen bonds in their internal structure, leading to the overgrowth of specific crystal surfaces, thus making the formation of needle habits . Unfortunately, the process conditions have a much weaker ability to modify the crystal habits of strongly hydrogen-bonded systems.…”

Section: Introductionmentioning

confidence: 99%

Insight into the Role of Hydroxypropyl Cellulose in Tuning Crystallization Behaviors of dl-Methionine

Yin,

Xia,

Chen

et al. 2024

Chem Bio Eng.

View full text Add to dashboard Cite

Efficient regulation of DL-methionine (DL-met) crystallization behavior remains of great interest since it usually appears in the form of needles or flakes, which is prone to cause problems in downstream processes. In this study, the crystallization process and crystal morphology of DL-met were focused with hydroxypropyl cellulose (HPC) as the tuning additive. The crystallization behaviors of DL-met with HPC were investigated through experiments and theoretical calculations from thermodynamic and kinetic perspectives to understand the mechanism of HPC in the DL-met crystal morphology. It was found that HPC could raise the interfacial energy γ, making nucleation more difficult. Furthermore, the inhibitory effect of HPC on the axial direction growth was much stronger than that on the radial direction, thereby changing the DL-met crystal morphology from rod-like to block-like. Theoretical calculations explained the underlying mechanism of HPC in regulating crystal habits. Due to the structural differences between different crystal surfaces, HPC exhibited a stronger hydrogen bonding with the (111) crystal surface, thus notably hindering its growth, specifically in the axial direction.

show abstract

“…Generally, crystal habit and other characteristics can be controlled by manipulating the growth conditions of crystals . Factors that influence crystal growth include the addition of seed crystals, processing methods, crystal growth conditions, solvents, − additives, , etc. Introducing seed crystals of specific size and habit can generate crystals with similar characteristics.…”

Section: Introductionmentioning

confidence: 99%

Mechanistic Insights into the Crystal Habit of d-Xylose in the Presence of Solvents and Additives

Zhao,

Han,

Gao

et al. 2023

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

D-Xylose has wide applications in industries such as food, pharmaceuticals, and energy and chemical engineering. Understanding its crystal habit and particle size is important for its further application. In this study, molecular dynamics simulations were used to explore how different solvents and additives affect the crystal habit of D-xylose. By considering surface properties and calculating diffusion coefficients, the interactions and distribution of electrostatic potentials were analyzed. The results showed that solvents including DMSO, methanol, and DMF had varying diffusion coefficients on crystal surfaces. Solvent polarity influenced hydrogen bonding distance, affecting crystal growth rates. Except for Tween 80, the increase in additive concentration was favorable in reducing the aspect ratio. This study demonstrates the potential of the atomic environment model to investigate sugar crystal habits and provides insights into controlling the aspect ratio of D-xylose with additive. These findings pave the way for future research on D-xylose crystals with smaller aspect ratios.

show abstract

The polymorph and crystal habit control of dl-methionine assisted by ultrasound

Cited by 12 publications

References 37 publications

An Overview on Polymorph Preparation Methods of Active Pharmaceutical Ingredients

An Overview on Polymorph Preparation Methods of Active Pharmaceutical Ingredients

Insight into the Role of Hydroxypropyl Cellulose in Tuning Crystallization Behaviors of dl-Methionine

Mechanistic Insights into the Crystal Habit of d-Xylose in the Presence of Solvents and Additives

Contact Info

Product

Resources

About