The Polymorphic Forms of α1-Acid Glycoprotein of Normal Caucasian Individuals*

Schmid, Karl; Binette, J. P.; Tokita, K; Мороз, Л. В.; Yoshizaki, H

doi:10.1172/jci105108

Cited by 32 publications

(12 citation statements)

References 8 publications

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“…Polymorphism of the intact glycoprotein is manifested by a variable number of bands on starch-gel electrophoresis at pH 2.9 (3). After removal of the sialyl residues by either enzymatic (4) or acid (5) hydrolysis, the variants are distinguished on starch-gel electrophoresis at pH 5.0 by a major slow moving band, a major fast band, or both bands in equal concentration.…”

Section: Introductionmentioning

confidence: 99%

Inheritance of human α1-acid glycoprotein (orosomucoid) variants

Johnson¹,

Schmid²,

Alper³

1969

J. Clin. Invest.

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Section: Introductionmentioning

confidence: 99%

Inheritance of human α1-acid glycoprotein (orosomucoid) variants

Johnson¹,

Schmid²,

Alper³

1969

J. Clin. Invest.

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“…The obtained sera amounting to 13 to 22 ml were fractionated by a modification of Cohn methods 6 and 10 (11,12). The resulting Fractions VI were chromatographed on Amberlite IRC-50 (12,13).…”

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confidence: 99%

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confidence: 99%

“…The resulting Fractions VI were chromatographed on Amberlite IRC-50 (12,13). The isolated, homogeneous ai-acid glycoprotein preparations were treated with Clostridium perfringens neuraminidase (14) and then analyzed by starch gel electrophoresis at pH 5 (11,12). In control experiments using normal pooled a,-acid glycoprotein it could be demonstrated that over 99% of the sialic acid was cleaved off and that on starch gel electrophoresis the expected patterns were obtained (11).…”

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confidence: 99%

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The constancy of the alpha-1-acid glycoprotein variants of normal adults under conditions of severe stress.

Tokita¹,

Burke²,

Yoshizaki³

et al. 1966

J. Clin. Invest.

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“…Recent investigations of the polymorphism of a1-acid glycoprotein demonstrated that this blood globulin may resolve on starch gel electrophoresis in five, six, seven, or eight bands depending on the individual from whom the glycoprotein was derived (1). However, it was noted earlier that pooled a,-acid glycoprotein from which the sialic acid had been split off enzymatically exhibited only two main bands (2).…”

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confidence: 99%