The polymorphism of estrogen receptor α is important for metabolic consequences associated with menopause

Pinkas, Jarosław; Gujski, Mariusz; Wierzbińska-Stępniak, Anna; Owoc, Alfred; Bojar, Iwona

doi:10.5603/ep.a2016.0058

Cited by 14 publications

(23 citation statements)

References 22 publications

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“…It is possible that at the luteal phase of the cycle in younger women factors different from estradiol have crucial effects on skin moisture, while in older women (around the menopause) the moisture depends mainly on estradiol concentration, but it cannot be too high. It is known that estrogens have a wide effect not only on the skin, but also on the entire metabolism acting via different membrane and intracellular receptors [14-16]. …”

Section: Resultsmentioning

confidence: 99%

Analysis of the Effect of Serum Estradiol Concentration on Facial Skin Moisture, Pore Width, Discoloration and Smoothness in 16- to 50-Year-Old Women at the 5th and 25th Days of the Menstrual Cycle

Jabłońska¹,

Mielicki

2019

Skin Pharmacol Physiol

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Background/Aims: Analysis of the relationship between the estradiol blood concentration and the skin moisture, pore width, discoloration and smoothness in differently aged women on the 5th and 25th days of the menstrual cycle. Methods: The study involved 57 women divided into 4 age groups. Measurements of skin moisture, pore width, discoloration and smoothness were performed using the Aramo SG Aram Huvis device. The estradiol serum concentration was determined by radioimmunoassay. Results: In the luteal phase of the cycle, facial skin moisture increases from 93.5% of the correct standard moisture index in the youngest to 115.5% in the oldest group. A positive correlation (r² = 0.45) between estradiol concentration and skin moisture was observed on the 5th day of the cycle in 40- to 50-year-olds. For women on the 25th day of the menstruation cycle, estrogen concentration below the normal range was more beneficial for skin smoothness and pore width for the oldest group. The difference was not statistically significant (p > 0.05); however, in the 40- to 50-year age group, skin smoothness was much better (43.5 ± 6.7%) for low estradiol while it was 37.5 ± 4.7% in the 20- to 29-year age group. Similarly, in the 40- to 50-year age group, skin pore width was much smaller (35.2 ± 15.7%) for low estradiol while it was 54.3 ± 28.8% in the 20- to 29-year age group. Conclusions: Skin moisture was related to the concentration of estradiol only in the oldest examined group of women regardless of the phase of menstrual cycle. In the 40- to 50-year-old group of women, the low level of estradiol on the 25th day of the cycle is better used to maintain a good facial skin appearance and has a positive influence not only on skin moisture, but also on pore width and skin smoothness.

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Section: Resultsmentioning

confidence: 99%

Analysis of the Effect of Serum Estradiol Concentration on Facial Skin Moisture, Pore Width, Discoloration and Smoothness in 16- to 50-Year-Old Women at the 5th and 25th Days of the Menstrual Cycle

Jabłońska¹,

Mielicki

2019

Skin Pharmacol Physiol

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“…Ao reunir as evidências científicas, deseja-se fornecer um embasamento teórico breve a todos os profissionais que atuam, principalmente, na Unidade Básica de Saúde, pois grande parte da população feminina desconhece o período menopausal e suas particularidades, em razão da escassez de uma assistência integral. PINKAS et al, 2016).…”

Section: Brazilian Journal Of Health Reviewunclassified

“…A Síndrome Metabólica, por sua vez, tem papel importante na deterioração cognitiva, pois as alterações vasculares da substância branca geram déficits na atenção, função executiva, memória, velocidade de processamento e emoções, evidenciando a importância de sua prevenção (PINKAS et al, 2016).…”

Section: Metodologiaunclassified

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Impactos da menopausa na saúde da mulher / Impacts of menpause on women’s health

Lins

Regis

Fernandes

et al. 2020

BJHR

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A menopausa corresponde ao último ciclo menstrual, sendo somente reconhecida depois de 12 meses, e ocorre, em média, aos 51 anos. Dessa forma, ela pode ser caracterizada como de início precoce (antes dos 40 anos) ou tardio (depois dos 55 anos). Neste cenário, as flutuações hormonais levam a alterações, não só na função reprodutiva, mas em outras importantes áreas corporais. Vale salientar que a amenorreia pode ser, também, de causa induzida, decorrente da remoção de partes do sistema reprodutivo feminino, por exemplo. Assim, a parada da atividade ovariana induz um caráter inflamatório crônico, aumentando a suscetibilidade da mulher a diversas doenças. Nessa perspectiva, o presente estudo tem como objetivo analisar as principais características da menopausa, bem como os aspectos psicológicos, o seu impacto na vida da mulher e a qualidade da assistência proporcionada pela Atenção Primária à saúde feminina. Realizou-se uma revisão integrativa da literatura nas bases de dados Medline (via PubMed) e Lilacs (via BVS), a partir da utilização de descritores (MeSH e DeCS). Aplicou-se os filtros de artigos publicados durante o período de 2015 a 2020, texto completo gratuito, pesquisas realizadas em humanos e sexo feminino. Dessa forma, foram encontrados um total de 3.548 artigos, dos quais, após a leitura dos títulos, resumos e texto na íntegra, 27 foram selecionados para compor a revisão. A menopausa pode ser assintomática ou sintomática e seus impactos levam a alterações na função reprodutiva e em outras áreas do corpo e da mente, atingindo os aspectos hormonais, imunológicos, emocionais, estressantes e sociais. O que reflete a importância da promoção à saúde ao público feminino de forma direcionada, integral, singular e de qualidade.

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“…The risk of diabetes and cardiovascular diseases in women increases with age. These diseases cause the deterioration in the functioning of the entire organism, therefore contributing to an increased mortality and disability [23].…”

Section: Objectivementioning

confidence: 99%

Impact of menopause on women's health

Iwanowicz-Palus¹,

Świst²,

Skurzak³

et al. 2019

Med Og Nauk Zdr.

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Perimenopause is the process of a gradual decline in the production of hormones by the female reproductive system, accompanied by various body changes. These changes cause both somatic and mental symptoms in women which vary in intensity, including inter alia vasomotor disorders and psychiatric issues. Urogenital atrophy and related sexual dysfunctions, as well as possible cardiovascular diseases, osteoporosis, and musculoskeletal disorders, occur at a later period. Perimenopausal symptoms negatively affect women's everyday lives, their functions and professional responsibilities, as well as their family relations, in particular if their family show neither interest nor support, and their partner is unwilling to be of assistance. Menopause involves several somatic and mental changes in women. Unhealthy lifestyle habits, such as poor nutrition and physical inactivity, may aggravate the condition of perimenopausal women. Women who lack a positive attitude frequently experience mental and somatic symptoms associated with menopause, exhibiting a lower esteem and low degree of satisfaction with life. Contemporary women are professionally and socially active. They value satisfaction, fitness and attractiveness. These are also the social norms they are subjected to in their communities, and by failing to conform, women risk being regarded as negligent. Furthermore, hormonal changes related to perimenopause cause somatic and mental symptoms. These occur in a highly individual manner, depending on the situation of a given woman. They may affect her self-esteem and satisfaction with life. The aim of the study is to present the impact of menopause on women's lives.

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The polymorphism of estrogen receptor α is important for metabolic consequences associated with menopause

Cited by 14 publications

References 22 publications

Analysis of the Effect of Serum Estradiol Concentration on Facial Skin Moisture, Pore Width, Discoloration and Smoothness in 16- to 50-Year-Old Women at the 5th and 25th Days of the Menstrual Cycle

Analysis of the Effect of Serum Estradiol Concentration on Facial Skin Moisture, Pore Width, Discoloration and Smoothness in 16- to 50-Year-Old Women at the 5th and 25th Days of the Menstrual Cycle

Impactos da menopausa na saúde da mulher / Impacts of menpause on women’s health

Impact of menopause on women's health

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