The Polyphenolic Compound Resveratrol Attenuates Pain: Neurophysiological Mechanisms

Takeda, Masatoshi; Takehana, Shiori; Shimazu, Yoshihito

doi:10.1016/b978-0-12-813006-3.00018-0

Cited by 2 publications

(2 citation statements)

References 88 publications

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“…Furthermore, Resv had a signifcant efect on reduction of VAS-10 pain scores. Te suggested mechanism of Resv in the amelioration of pain was elucidated by the reduction in the production of prostaglandins [50], via various voltagedependent ion/ligand-gated channels, neurotransmitter receptors, and infammatory signaling cascades [51]. Te P2X7 and P2X3 receptors in the dorsal root ganglia (DRG) are associated with infammatory and neuropathic pain [52].…”

Section: Discussionmentioning

confidence: 99%

Impact of Resveratrol and Pharmaceutical Care on Type 2 Diabetes Mellitus and Its Neuropathic Complication: A Randomized Placebo Controlled Clinical Trial

Amin,

Marouf,

Namiq

et al. 2024

Journal of Clinical Pharmacy and Therapeutics

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Background. Management of diabetic neuropathy (DN) is a challenging issue. Therefore, integration of pharmaceutical care provided by the clinical pharmacists with pharmacotherapy may provide multifaceted approach to target the management of hyperglycemia and diabetic neuropathic complication. This study aimed to evaluate the effects of resveratrol (Resv) and/or pharmaceutical care (PC) on glycemic control and amelioration of diabetes-associated neuropathic complications. Patients and Methods. A four-arm randomized placebo-controlled clinical trial assigned 120 patients from the Diabetes and Endocrinology Center in Sulaymaniyah City, Iraq. The patients were divided into four groups. The Resv group (n = 30) received 500 mg Resv capsules once daily. The Placebo group (n = 30) received placebo capsules. Resv + PC (n = 30) received Resv 500 mg capsules with PC. Placebo + PC (n = 30) received placebo capsule plus PC. The duration of the intervention was 90 days. Drug therapy problems (DTPs) have been utilized as an important domain in PC. Clinical signs, symptoms, and neuropathic abnormalities were assessed using the Michigan Neuropathy Screening Instrument (MNSI), Douleur Neuropathique 4 (DN4) questions, and nerve conduction studies (NCSs) of the lower-limb sensory and motor nerves. Results. 97 patients from all the groups completed the study. At baseline, 84% of the Resv, 87% of the Placebo, and 92% of each of Resv + PC and Placebo + PC groups, respectively, had at least one DTP. The provision of PC resulted in a dramatic reduction in the number of DTP. Resveratrol with PC significantly ameliorated hyperglycemic status, neuropathic signs, and symptoms, as evidenced by a decrease in MNSI and DN4 scores and improvement in electroneurographic parameters. Conclusion. These findings support the integration of the PC concept into a pharmacotherapy intervention; they also encourage supplementation of Resv with conventional diabetes therapy to emphasize on the importance of this herbal medicine with the provision of PC in the management of diabetes and its neuropathic complications. This trial is registered with NCT05172947.

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Section: Discussionmentioning

confidence: 99%

Impact of Resveratrol and Pharmaceutical Care on Type 2 Diabetes Mellitus and Its Neuropathic Complication: A Randomized Placebo Controlled Clinical Trial

Amin,

Marouf,

Namiq

et al. 2024

Journal of Clinical Pharmacy and Therapeutics

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“…These findings suggest that local administration of resveratrol to the peripheral receptive field inhibits TRPA1 and Nav channels and facilitate the opening of Kv channels in the peripheral free nerve endings of TG neurons, thereby decreasing the excitability of SpVc WDR neurons. This strongly suggests that resveratrol may be a substitute for local anesthetics, without any side effects on the heart and cardiovascular system [41].…”

Section: Local Anesthetic Effect Of Phytochemicals On Nociceptive Painmentioning

confidence: 98%

Neurophysiological Mechanisms Underlying the Attenuation of Nociceptive and Pathological Pain by Phytochemicals: Clinical Application as Therapeutic Agents

Takeda

2024

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Although phytochemicals are plant-derived toxins that are primarily produced by plants as a form of defense against insects or microbes, several lines of studies have demonstrated that phytochemicals (e.g., polyphenols, carotenoids, and amino acids) have several beneficial biological actions for human health, such as anti-oxidative, anti-inflammatory, and cardioprotective effects. Recent studies have demonstrated that phytochemicals can modulate neuronal excitability in the nervous system, including nociceptive sensory transmission, so it is possible that phytochemicals could be complementary alternative medicine candidates; specifically, therapeutic agents against pain. The focus of this review is to elucidate the mechanisms underlying the modulatory effects of phytochemicals on neuronal electrical signals, such as generator potentials, action potentials, and postsynaptic potentials, in the nociceptive pathway neurons resulting in potential local anesthetic effects, intravenous anesthesia and analgesic effects, and inflammatory pain relief effects. In addition, we discuss the contribution of phytochemicals to the relief of nociceptive and/or pathological pain and their potential clinical application on the basis of our recent studies in vivo.

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The Polyphenolic Compound Resveratrol Attenuates Pain: Neurophysiological Mechanisms

Cited by 2 publications

References 88 publications

Impact of Resveratrol and Pharmaceutical Care on Type 2 Diabetes Mellitus and Its Neuropathic Complication: A Randomized Placebo Controlled Clinical Trial

Impact of Resveratrol and Pharmaceutical Care on Type 2 Diabetes Mellitus and Its Neuropathic Complication: A Randomized Placebo Controlled Clinical Trial

Neurophysiological Mechanisms Underlying the Attenuation of Nociceptive and Pathological Pain by Phytochemicals: Clinical Application as Therapeutic Agents

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