The polysaccharides from seeds of Glycyrrhiza uralensis ameliorate metabolic disorders and restructure gut microbiota in type 2 diabetic mice

Ye, Jianming; Ma, Jie; Rozi, Parhat; Kong, Lingming; Zhou, Jianzhong; Luo, Yane; Yang, Haiyan

doi:10.1016/j.ijbiomac.2024.130622

Cited by 11 publications

(2 citation statements)

References 68 publications

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“…In an STZ-induced mouse model, GU-Polysaccharides (GUP) were able to restore glucose homeostasis of the diabetic animals while also lowering lipid levels and liver compromise. At a microbiome level, it lowered the overall abundance of Firmicutes and raised Bacteroidetes, a profile attributed to insulin resistance in another previous study [56,57].…”

Section: Diabetes Lipid Metabolism and Glucose Tolerancementioning

confidence: 70%

“…Another species composing the Chinese pharmacopeia is Glycyrrhiza uralensis (GU). Its polysaccharide extract was found to have a purity of 90% carbohydrate content, 230 kDa average molecular weight, and was mostly composed of Manp and Galp residues [55,56]. In an STZ-induced mouse model, GU-Polysaccharides (GUP) were able to restore glucose homeostasis of the diabetic animals while also lowering lipid levels and liver compromise.…”

Section: Diabetes Lipid Metabolism and Glucose Tolerancementioning

confidence: 99%

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Polysaccharides from Medicinal Plants: Bridging Ancestral Knowledge with Contemporary Science

Pedrosa,

Fabi

2024

Plants

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Plants are a core part of cultural identity, as part of a diet, decorations, ceremonies, or as medicinal agents. Empirical knowledge regarding plants and their healing potential has existed worldwide for centuries. With the advance of science and technology, not only is the refinement of such sources or isolation of specific compounds possible, but these compounds can also be characterized based on their natural occurrence. Besides their importance for plant metabolism and structure, polysaccharides have been demonstrated to have substantial positive human health impacts on inflammation, metabolism, oxidative stress, and others. As an inherent part of plant cell walls, many polysaccharides from medicinal herbs, such as fructans, glucans, and pectins, have been extracted and analyzed for their structure and function. However, a review summarizing a significant portion of these studies was still unavailable. This review helps to fill the knowledge gap between polysaccharide bioactivity, their structure, and their plant matrix sources, focusing on historical medicinal usage.

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Section: Diabetes Lipid Metabolism and Glucose Tolerancementioning

confidence: 70%

Section: Diabetes Lipid Metabolism and Glucose Tolerancementioning

confidence: 99%

Polysaccharides from Medicinal Plants: Bridging Ancestral Knowledge with Contemporary Science

Pedrosa,

Fabi

2024

Plants

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Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic‐Comorbidities Related Signatures in Craniopharyngioma

Lin,

Ye,

Cao

et al. 2024

Advanced Science

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Craniopharyngioma (CP) is an intracranial tumor with high mortality and morbidity. Though biologically benign, CP will damage the hypothalamus, inducing comorbidities such as obesity, metabolic syndrome, and cognitive impairments. The roles of gut microbiome and serum metabolome in CP‐associated hypothalamic comorbidities are aimed to be explored. Patients with CP are characterized by increased Shannon diversity, Eubacterium, Clostridium, and Roseburia, alongside decreased Alistipes and Bacteroides. CP‐enriched taxa are positively correlated with dyslipidemia and cognitive decline, while CP‐depleted taxa are negatively associated with fatty liver. Subsequent serum metabolomics identified notably up‐regulated purine metabolism, and integrative analysis indicated an association between altered microbiota and elevated hypoxanthine. Phenotypic study and multi‐omics analysis in the Rax‐CreERT2::BrafV600E/+::PtenFlox/+ mouse model validated potential involvement of increased Clostridium and dysregulated purine metabolism in hypothalamic comorbidities. To further consolidate this, intervention experiments are performed and it is found that hypoxanthine co‐variated with the severity of hypothalamic comorbidities and abundance of Clostridium, and induced dysregulated purine metabolism along with redox imbalance in target organs (liver and brain cortex). Overall, the study demonstrated the potential of increased Clostridium and up‐regulated purine metabolism as signatures of CP‐associated hypothalamic‐comorbidities, and unveiled that elevated Clostridium, dysregulated purine metabolism, and redox imbalance may mediate the development and progression of CP‐associated hypothalamic‐comorbidities.

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Biological insights and therapeutic potential of Glycyrrhiza uralensis and its bioactive compounds: an updated review

Shaikh,

Ahmad,

Lim

et al. 2024

Arch. Pharm. Res.

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The polysaccharides from seeds of Glycyrrhiza uralensis ameliorate metabolic disorders and restructure gut microbiota in type 2 diabetic mice

Cited by 11 publications

References 68 publications

Polysaccharides from Medicinal Plants: Bridging Ancestral Knowledge with Contemporary Science

Polysaccharides from Medicinal Plants: Bridging Ancestral Knowledge with Contemporary Science

Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic‐Comorbidities Related Signatures in Craniopharyngioma

Biological insights and therapeutic potential of Glycyrrhiza uralensis and its bioactive compounds: an updated review

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