The polysaccharides from the fruits of Lycium barbarum ameliorate high-fat and high-fructose diet-induced cognitive impairment via regulating blood glucose and mediating gut microbiota

Tian, Xinyi; Dong, Wei; Zhou, Wangting; Yan, Yamei; Lu, Lu; Mi, Jia; Cao, Youlong; Sun, Yi; Zeng, Xiaoxiong

doi:10.1016/j.ijbiomac.2023.129036

Cited by 8 publications

(4 citation statements)

References 78 publications

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“…The active ingredients of goji berries can also improve microbial diversity in the gastrointestinal (GI) tract. For example, they increase the abundance of common probiotic bacteria, including Bifidobacteria [ 147 ], Lactobacilli , and Lactococcus [ 148 ]; inhibit the growth of disease-related microbes such as Lachnospiraceae and Bacteroides [ 149 ]; and affect microbes associated with the intestinal environment, like Allobaculum and Romboutsia , which can synthesize short-chain fatty acids (SCFAs) to alter the pH and nutritional status of the gut [ 148 , 150 , 151 ]. Through their complex influence on GI microbial interactions and interactions between microorganisms and their hosts, as well as the exchange and transformation of metabolites, the active ingredients in goji berries actively participate in immune regulation and energy metabolism and modulate neural messaging [ 152 ].…”

Section: Influence Of the Active Ingredients In Goji Berries On Gut M...mentioning

confidence: 99%

“…Therefore, they assist in the treatment of various metabolic diseases, including GI tract inflammation [ 153 , 154 , 155 ], nonalcoholic fatty liver disease [ 156 ], alcoholic liver disease [ 157 ], and diabetes [ 149 , 158 , 159 ]. Many studies have shown that LBPs could alleviate cognitive impairment and neuroinflammation caused by high-fat diets [ 148 , 160 , 161 ]. Recent clinical studies have demonstrated that LBPs can improve symptoms of subthreshold depression in adolescents without adverse side effects [ 162 ], indicating the potential of goji berries to be incorporated into daily diets as a healthy food option ( Figure 9 ).…”

Section: Influence Of the Active Ingredients In Goji Berries On Gut M...mentioning

confidence: 99%

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The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways

Jiang,

Chen,

Liao

et al. 2024

Plants

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Natural plants contain numerous chemical compounds that are beneficial to human health. The berries from the Lycium genus are widely consumed and are highly nutritious. Moreover, their chemical constituents have attracted attention for their health-promoting properties. In East Asia, there are three varieties of the Lycium genus (Lycium barbarum L., Lycium chinense Miller, and L. ruthenicum Murray) that possess medicinal value and are commonly used for treating chronic diseases and improving metabolic disorders. These varieties are locally referred to as “red Goji berries” or “black Goji berries” due to their distinct colors, and they differ in their chemical compositions, primarily in terms of carotenoid and anthocyanin content. The pharmacological functions of these berries include anti-aging, antioxidant, anti-inflammatory, and anti-exercise fatigue effects. This review aims to analyze previous and recent studies on the active ingredients and pharmacological activities of these Lycium varieties, elucidating their signaling pathways and assessing their impact on the gut microbiota. Furthermore, the potential prospects for using these active ingredients in the treatment of COVID-19 are evaluated. This review explores the potential targets of these Lycium varieties in the treatment of relevant diseases, highlighting their potential value in drug development.

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Section: Influence Of the Active Ingredients In Goji Berries On Gut M...mentioning

confidence: 99%

Section: Influence Of the Active Ingredients In Goji Berries On Gut M...mentioning

confidence: 99%

The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways

Jiang,

Chen,

Liao

et al. 2024

Plants

View full text Add to dashboard Cite

show abstract

“…Downregulation of the expression of TNF-α, and upregulation of the expression of MUC-2 and GPRs [ 112 ].…”

Section: Natural Compounds That Regulate Glucolipid Metabolismmentioning

confidence: 99%

“…These findings suggested that acetic acid may bind to receptors on intestinal neurons and regulate duodenal hypercontractility, thereby improving glucose homeostasis. A study by Xinyi Tian et al [ 112 ]. revealed that polysaccharides increase the relative abundance of Allobaculum and Lactococcus , decrease the relative abundance of Proteobacteria , and increase the level of SCFAs and the expression of related G-protein-coupled receptors in the intestinal bacterial community of mice fed a high-sugar and high-fat diet.…”

Section: Natural Compounds That Regulate Glucolipid Metabolismmentioning

confidence: 99%

Mechanisms of regulation of glycolipid metabolism by natural compounds in plants: effects on short-chain fatty acids

Li,

Zhao,

Tian

et al. 2024

Nutr Metab (Lond)

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Background Natural compounds can positively impact health, and various studies suggest that they regulate glucose‒lipid metabolism by influencing short-chain fatty acids (SCFAs). This metabolism is key to maintaining energy balance and normal physiological functions in the body. This review explores how SCFAs regulate glucose and lipid metabolism and the natural compounds that can modulate these processes through SCFAs. This provides a healthier approach to treating glucose and lipid metabolism disorders in the future. Methods This article reviews relevant literature on SCFAs and glycolipid metabolism from PubMed and the Web of Science Core Collection (WoSCC). It also highlights a range of natural compounds, including polysaccharides, anthocyanins, quercetins, resveratrols, carotenoids, and betaines, that can regulate glycolipid metabolism through modulation of the SCFA pathway. Results Natural compounds enrich SCFA-producing bacteria, inhibit harmful bacteria, and regulate operational taxonomic unit (OTU) abundance and the intestinal transport rate in the gut microbiota to affect SCFA content in the intestine. However, most studies have been conducted in animals, lack clinical trials, and involve fewer natural compounds that target SCFAs. More research is needed to support the conclusions and to develop healthier interventions. Conclusions SCFAs are crucial for human health and are produced mainly by the gut microbiota via dietary fiber fermentation. Eating foods rich in natural compounds, including fruits, vegetables, tea, and coarse fiber foods, can hinder harmful intestinal bacterial growth and promote beneficial bacterial proliferation, thus increasing SCFA levels and regulating glucose and lipid metabolism. By investigating how these compounds impact glycolipid metabolism via the SCFA pathway, novel insights and directions for treating glucolipid metabolism disorders can be provided.

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Neuroprotective Roles of Lauric Acid and Resveratrol: Shared Benefits in Neuroinflammation and Anxiety, Distinct Effects on Memory Enhancement

Kisioglu,

Onal,

Karabulut

et al. 2024

Food Science & Nutrition

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Neuroinflammation can be triggered by a high‐fat/high‐fructose diet (HFFD), and CD36 may be an underlying mechanism. Lauric acid (LA), the major fatty acid in coconut oil, and resveratrol, the plant‐based polyphenolic compound, may exert anti‐inflammatory effects. Therefore, this study investigated the possible effects of LA and resveratrol on diet‐induced neuroinflammation and CD36. Healthy male C57BL/6 mice (8 weeks of age, n = 31) were fed a control diet (10%kcal fat) or diets containing high fat (60%kcal fat) and fructose (5% w/v fructose drinking water) for 6 weeks, ad libitum. Supplemented to the HFFD, mice daily received resveratrol (7.5 mg/kg) (HFFD‐RSV) or LA (750 mg/kg) (HFFD‐LA). At the end of the study, HFFD resulted in anxiety‐like behavior, reduced locomotor activity, neuroinflammation (increased brain GFAP, IL‐6, MCP‐1, IFN‐γ, TNF‐α), and systemic inflammation (increased plasma GFAP, IFN‐γ, TNF‐α, IL‐12p70, reduced plasma IL‐10). HFFD‐RSV and HFFD‐LA alleviated HFFD‐induced anxiety‐like behavior, neuroinflammation, and systemic inflammation. HFFD‐LA improved memory. Brain and plasma CD36 levels were increased by HFFD and reduced by HFFD‐RSV or HFFD‐LA. Dietary resveratrol and LA intake may alleviate HFFD‐induced neuroinflammation, systemic inflammation, and anxiety‐like behavior and improve memory, as CD36 may be an underlying mechanism.

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The polysaccharides from the fruits of Lycium barbarum ameliorate high-fat and high-fructose diet-induced cognitive impairment via regulating blood glucose and mediating gut microbiota

Cited by 8 publications

References 78 publications

The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways

The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways

Mechanisms of regulation of glycolipid metabolism by natural compounds in plants: effects on short-chain fatty acids

Neuroprotective Roles of Lauric Acid and Resveratrol: Shared Benefits in Neuroinflammation and Anxiety, Distinct Effects on Memory Enhancement

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