The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat

Kelly, Laura C.; Grehan, Belinda; Chiesa, Andrea Della; O’Mara, Shane M.; Downer, Eric J.; Sahyoun, George; Massey, Karen A.; Nicolaou, Anna; Lynch, Marina A.

doi:10.1016/j.neurobiolaging.2010.04.001

Cited by 117 publications

(98 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[41][42][43] The mechanism of the protective effect of DPA on prostate cancer may be explained by biochemical processes involving: reduced prostacyclin production, expression of inflammatory genes and TNF-induced necrotic cell death; competition with cycloxygenase 2 (COX2) enzymes resulting to anti-neoplastic activity via proapoptotic pathway; and inhibition of angiogenesis. [44][45][46][47][48][49] Detection of such association may suggest that serum level DPA implicates individual genetic difference in biochemical characteristics of enzymatic activities, which may be further investigated as a probable new serum biomarker for prostate cancer risk assessment in the future.…”

Section: Discussionmentioning

confidence: 99%

The relevance of serum levels of long chain omega-3 polyunsaturated fatty acids and prostate cancer risk: A Meta-analysis

Chua

Sio²,

Sorongon³

et al. 2013

CUAJ

View full text Add to dashboard Cite

Objective:Our objective was to systematically analyze the evidence for an association between serum level long chain omega-3 polyunsaturated fatty acid (n-3 PUFA) and prostate cancer risk from human epidemiological studies. Study Procedures: We searched biomedical literature databases up to November 2011 and included epidemiological studies with description of long chain n-3 PUFA and incidence of prostate cancer in humans. Critical appraisal was done by two independent reviewers. Data were pooled using the general variance-based method with random-effects model; effect estimates were expressed as risk ratio with 95% confidence interval (CI). Heterogeneity was assessed by Chi 2 and quantified by I 2 , publication bias was also determined. Results: In total, 12 studies were included. Significant negative association was noted between high serum level of n-3 PUFA docosapentaenoic acid (DPA) and total prostate cancer risk (RR:0.756; 95% CI 0.599, 0.955; p = 0.019). Likewise, a positive association between high blood level of fish oil contents, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and high-grade prostate tumour incidence (RR:1.381; 95% CI 1.050, 1.817; p = 0.021) was noted; however, this finding was evident only after adjustment was done on interstudy variability through the removal of a lower quality study from the pool. Conclusions: High serum levels of long chain n-3 PUFA DPA is associated with reduced total prostate cancer risk. While high blood level of EPA and DHA is possibly associated with increased high-grade prostate tumour risk.

show abstract

Section: Discussionmentioning

confidence: 99%

The relevance of serum levels of long chain omega-3 polyunsaturated fatty acids and prostate cancer risk: A Meta-analysis

Chua

Sio²,

Sorongon³

et al. 2013

CUAJ

View full text Add to dashboard Cite

show abstract

“…The increases in MTT and CTT are probably due to a combination of decreased blood flow and altered perfusion coefficient of the tissue (Kelly et al, 2009). MTT has been shown to correlate with accumulation of lactate following stroke suggesting that it may provide a marker of ischemia (Cvoro et al, 2009) and, in this context, it is interesting that there is evidence of oxidative changes in the brain of aged rats (Kelly et al, 2011;O'Donnell et al, 2000). These changes cannot be attributed to any age-related difference in hippocampal volume because, although a decrease in cortical thickness was observed, we found no evidence of any difference in hippocampal volume in aged, compared with young, rats.…”

Section: Discussionmentioning

confidence: 99%

The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability

Blau¹,

Cowley²,

O'Sullivan³

et al. 2012

Neurobiology of Aging

Self Cite

View full text Add to dashboard Cite

In view of the increase in the aging population and the unavoidable parallel increase in the incidence of age-related neurodegenerative diseases, a key challenge in neuroscience is the identification of clinical signatures which change with age and impact on neuronal and cognitive function. Early diagnosis offers the possibility of early therapeutic intervention, thus magnetic resonance imaging (MRI) is potentially a powerful diagnostic tool. We evaluated age-related changes in relaxometry, blood flow, and blood-brain barrier (BBB) permeability in the rat by magnetic resonance imaging and assessed these changes in the context of the age-related decrease in synaptic plasticity. We report that T2 relaxation time was decreased with age; this was coupled with a decrease in gray matter perfusion, suggesting that the observed microglial activation, as identified by increased expression of CD11b, MHCII, and CD68 by immunohistochemistry, flow cytometry, or polymerase chain reaction (PCR), might be a downstream consequence of these changes. Increased permeability of the blood-brain barrier was observed in the perivascular area and the hippocampus of aged, compared with young, rats. Similarly there was an age-related increase in CD45-positive cells by flow cytometry, which are most likely infiltrating macrophages, with a parallel increase in the messenger mRNA expression of chemokines IP-10 and MCP-1. These combined changes may contribute to the deficit in long-term potentiation (LTP) in perforant path-granule cell synapses of aged animals.

show abstract

“…Of particular interest, the lipid species showing the greatest change was DPAn-3. There have been many studies, both in vitro and in vivo, demonstrating the neuroprotective effects of DHA (Belayev et al, 2009;Ménard et al, 2009;Ward et al, 2010), but little work has been done on the role DPAn-3 can play in injury and disease (Kelly et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Improved Outcome after Peripheral Nerve Injury in Mice with Increased Levels of Endogenous Omega-3 Polyunsaturated Fatty Acids

Gladman¹,

Huang²,

Lim³

et al. 2012

J. Neurosci.

View full text Add to dashboard Cite

Functional recovery after a peripheral nerve injury (PNI) is often poor. There is a need for therapies that protect neurons against injury and enhance regeneration. Omega-3 polyunsaturated fatty acids (PUFAs) have been shown to have therapeutic potential in a variety of neurological disorders, including acute traumatic injury. The objective of this study was to assess the neuroprotective and proregenerative potential of -3 PUFAs in PNI. We investigated this in mice that express the fat-1 gene encoding for -3 fatty acid desaturase, which leads to an increase in endogenous -3 PUFAs and a concomitant decrease in -6 PUFAs. Dorsal root ganglion (DRG) neurons from wild-type or fat-1 mice were subjected to a mechanical strain or hypoxic injury, and cell death was assessed using ethidium homodimer-1 labeling. The fat-1 background appears to confer robust neuroprotection against both injuries. We then examined the early functional and morphological changes in wild-type and fat-1 mice after a sciatic nerve crush. An accelerated functional recovery 7 d after injury was seen in fat-1 mice when assessed using von Frey filaments and the sciatic nerve functional index. These observations were also mapped to changes in injury-related markers. The injury-induced expression of ATF-3 was decreased in the DRG of fat-1 mice, whereas the axons detected 6 mm distal to the crush were increased. Fat-1 animals also had some protection against muscle atrophy after injury. In conclusion, both in vitro and in vivo experiments support the idea that a higher endogenous -3 PUFA could lead to beneficial effects after a PNI.

show abstract

The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat

Cited by 117 publications

References 64 publications

The relevance of serum levels of long chain omega-3 polyunsaturated fatty acids and prostate cancer risk: A Meta-analysis

The relevance of serum levels of long chain omega-3 polyunsaturated fatty acids and prostate cancer risk: A Meta-analysis

The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability

Improved Outcome after Peripheral Nerve Injury in Mice with Increased Levels of Endogenous Omega-3 Polyunsaturated Fatty Acids

Contact Info

Product

Resources

About