The pontine micturition center projects to sacral cord GABA immunoreactive neurons in the cat

Blok, Bertil; Weerd, Henk de; Holstege, Gert

doi:10.1016/s0304-3940(97)00644-7

Cited by 133 publications

(65 citation statements)

References 17 publications

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“…A decrease in EUS-EMG activity may be induced by (1) decreased bladder contraction pressure because EUS activity changes according to bladder activity, (2) inhibition of EUS motoneurons because these neurons receive GABAergic innervation, 12 or (3) inhibition of C-fiber bladder afferents because a previous study indicated that hyperexcitability of C-fiber bladder afferents is also involved in DSD during voiding after SCI. 13 Since a low dose of muscimol inhibited both NVCs and MVP to a similar extent, and a high dose induced dribbling overflow incontinence in most rats, the first and second possibilities are more likely to be involved in suppression of EUS-EMG activity during GABA A receptor activation.…”

Section: Discussionmentioning

confidence: 99%

GABA Receptor Activation in the Lumbosacral Spinal Cord Decreases Detrusor Overactivity in Spinal Cord Injured Rats

et al. 2008

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Purpose-We investigated the effects of intrathecal application of GABA A and GABA B receptor agonists on detrusor overactivity in spinal cord injured rats.Materials and Methods-Adult female Sprague-Dawley rats were used. At 4 weeks after Th9-10 spinal cord transection, awake cystometry and recordings of external urethral sphincter electromyogram were performed to examine the effect of intrathecal application of GABA A and GABA B agonists (muscimol and baclofen, respectively) or GABA A and GABA B antagonists (bicuculline and saclofen, respectively) at the level of L6-S1 spinal cord. Expression of glutamate decarboxylase 67 mRNA in the L6-S1 spinal cord and dorsal root ganglia was also assessed.Results-Both muscimol and baclofen produced a dose-dependent inhibition of the number (51-73% decrease) and amplitude (35-93% decrease) of nonvoiding bladder contractions, and a decrease in micturition pressure. The effects of muscimol and baclofen were antagonized by bicuculline and saclofen, respectively. Bursting activity of external urethral sphincter electromyogram was inhibited corresponding to the inhibition of bladder activity by muscimol and baclofen. Glutamate decarboxylase 67 mRNA levels in the spinal cord and dorsal root ganglia was decreased (55% and 84%, respectively) after spinal cord transection.Conclusions-These results indicate that GABA A and GABA B receptor activation in the spinal cord inhibits detrusor overactiivty. The reduction in glutamate decarboxylase 67 mRNA suggests hypofunction of GABAergic inhibitory mechanisms in the spinal cord. Therefore, stimulation of spinal GABAergic mechanisms could be effective for the treatment of detrusor overactivity after spinal cord injury.

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Section: Discussionmentioning

confidence: 99%

GABA Receptor Activation in the Lumbosacral Spinal Cord Decreases Detrusor Overactivity in Spinal Cord Injured Rats

et al. 2008

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“…Blok et al (1997) demonstrated in cats a direct pathway from the PMC to the dorsal gray commissure of the sacral cord. It was suggested that the pathway produced relaxation of the external striated sphincter during micturition via inhibitory modulation by GABA neurons of the motoneurons in the sphincter of Onuf (Blok et al, 1997a). In rats, i.t.…”

Section: Pharmacology Of the Lower Urinary Tractmentioning

confidence: 99%

Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence

Andersson

Wein²

2004

Pharmacol Rev

455

364

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“…Activation of the PMC revealed by PET studies during the voiding phase (5)(6)(7)(8) has confirmed that the long -loop voiding reflex is excited during normal voiding. In addition, fMRI studies have shown that the PMC responds to bladder filling during the storage phase as well (both in normal subjects and in urge incontinent subjects prior to onset of detrusor overactivity, DO) (8)(9)(10).…”

Section: P O N T I N E M I C T U R I T I O N C E N T E R ( P M C )mentioning

confidence: 68%

CNS and bladder (short review for clinicians)

Tadić¹

2014

Acta Facultatis Medicae Naissensis

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Symptoms of bladder dysfunction are significant public health problem due to their prevalence, morbidity and treatment costs. Most stem from bladder control problem which is governed by the brain, yet we know little about CNS and bladder. Advances in brain imaging technology have brought new insight in how brain works in different bladder diseases and opened new possibilities to study lower urinary tract. Thus, it is important for urologists and clinicians alike to get informed about basic concepts of brain-bladder control. The aim of this article is to review basic neuroanatomy of central continence control based on the results of recent brain imaging studies in patients with symptoms of impaired bladder control.

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The pontine micturition center projects to sacral cord GABA immunoreactive neurons in the cat

Cited by 133 publications

References 17 publications

GABA Receptor Activation in the Lumbosacral Spinal Cord Decreases Detrusor Overactivity in Spinal Cord Injured Rats

GABA Receptor Activation in the Lumbosacral Spinal Cord Decreases Detrusor Overactivity in Spinal Cord Injured Rats

Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence

CNS and bladder (short review for clinicians)

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