The pontocerebellar projection: longitudinal zonal distribution of fibers from discrete regions of the pontine nuclei to vermal and parafloccular cortices in the rat

Serapide, Maria Francesca; Cicirata, F; Sotelo, Constantino; Pantò, Maria Rosita; Parenti, Rosalba

doi:10.1016/0006-8993(94)90362-x

Cited by 37 publications

(29 citation statements)

References 28 publications

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“…The LRtN projections to the cer ebellum are well documented. The distribution o f this projection was described as a symmetrical and parasagit tal pattern [19,21], which is also confirmed by our results. However, data from the present study suggest that pro jections from the LRtN overlap with NOS-containing patches in the paravermal region and in 1 case (from the We have noticed that mossy fiber afferents branch upon reaching the cerebellar cortex, to produce several rosettes (MF terminals).…”

Section: Discussionsupporting

confidence: 80%

“…The organization of these inputs, described as clusters within parasagittal bands, may be of critical importance in sensory processing [18][19][20][21], Schill ing et al [22] have reported that NOS expression in mouse cerebellar granule cells exhibits a patch-like pat tern of distribution, the functional significance of which is not clear. The similarities of their respective patterns of distribution suggested a potential relationship between the compartments o f NOS and clusters of mossy fiber ter minals.…”

mentioning

confidence: 99%

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Cerebellar Nitric Oxide Synthase Is Expressed within Granule Cell Patches Innervated by Specific Mossy Fiber Terminals: A Developmental Profile

Chen²,

Lin³

et al. 1997

Dev Neurosci

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The nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) staining technique was utilized as a marker of nitric oxide synthase (NOS) to map NOS expression in developing and adult rat cerebellum. NADPH-d-positive cells were first visualized in the cerebellar cortex at postnatal day 5 (PND5) which increased to peak levels by PND30 when they began to exhibit a patch-like organization. In order to determine the relationship of the NADPH-d staining pattern with mossy fiber innervation, mossy fiber projections were traced using cholera toxin B subunit or biocytin injected into the lateral reticular nuclei (LRtN) or pontine nuclei (PtN), respectively. Double staining revealed that the clustered mossy fiber terminals projecting from the ventrorostral LRtN and caudal PtN were well matched with NADPH-d-stained patches. This patch-like localization of NOS matched with specific mossy fiber terminals in adult cerebellum implicates these NOS patches as defining distinct anatomical zones.

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Section: Discussionsupporting

confidence: 80%

mentioning

confidence: 99%

Cerebellar Nitric Oxide Synthase Is Expressed within Granule Cell Patches Innervated by Specific Mossy Fiber Terminals: A Developmental Profile

Chen²,

Lin³

et al. 1997

Dev Neurosci

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“…In turn, the Purkinje cells within these bands project to specific regions of the fastigial and interposed nuclei (see Buisseret-Delmas and Angaut, 1993;Voogd and Glickstein, 1998, for review). Furthermore, anterograde tracing studies in the rat have shown that pontocerebellar and cuneocerebellar mossy fibers terminate in lobules VI/VII in parasagittal stripes (Serapide et al, 1994;TolFig. 9.…”

Section: Hsp25 Expression In the Czmentioning

confidence: 99%

Constitutive expression of the 25-kDa heat shock protein Hsp25 reveals novel parasagittal bands of Purkinje cells in the adult mouse cerebellar cortex

et al. 2000

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“…Anterograde studies of the projections from the LRN (Kü nzle, 1975;Chan-Palay et al, 1977) and from other major sources of mossy fibre afferents, such as the pontine nuclei (see, e.g., Kawamura and Hashikawa, 1981;Serapide et al, 1994), the dorsal column nuclei (see, e.g., Gerrits et al, 1985;Jasmin and Courville, 1987), and the spinal cord (see, e.g., Voogd, 1969;Matsushita and Yaginuma, 1989;Gravel and Hawkes, 1990), have revealed some evidence for the termination of mossy fibres in sagittal zones within the granular layer of the cerebellar cortex. These results, together with physiological studies (Ekerot and Larson, 1980) and the findings from the present retrograde study, strongly favour the proposition that at least some sources of mossy fibres are organised so that their projection to the cortex ''respects'' the olivocerebellar cortical zones.…”

Section: Sagittal Organisation Of Mossy Fibre Afferents To the Cerebementioning

confidence: 98%

Topographical organisation within the lateral reticular nucleus mossy fibre projection to the c1 and c2 zones in the rostral paramedian lobule of the cat cerebellum

Apps

Trott

1997

J. Comp. Neurol.

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The organisation of the projection from the principal lateral reticular nucleus (LRN) to the electrophysiologically defined cerebellar cortical c1 and c2 zones within apical folia of the forelimb-receiving area of the rostral paramedian lobule was investigated in cats. In individual experiments, small injections of either of two retrograde tracers, wheat germ agglutinin-horseradish peroxidase or fluorescent-tagged beads, were made into one or the other of the two zones. The mossy fibre projection from the LRN was found to arise almost entirely from the ipsilateral nucleus, primarily from its magnocellular region. In the pars anterior (folia 1-3) of the paramedian lobule, the projection to the c1 zone arose from cells located throughout most of the rostrocaudal extent of the magnocellular LRN, whereas the projection to the c2 zone was from cells in the rostral half of this region. There was also a small projection from cells in the dorsolateral parvicellular LRN to the c2 zone, but there was none to the c1 zone. Double-label experiments showed that, in territories within LRN where overlap occurred, cells that target either zone were intermingled, and, at most, about 9% of cells had axons that branched to innervate both zones. In the pars posterior (folia 4-6), cells targeting the two zones arose from largely overlapping areas throughout both the magnocellular and the dorsolateral parvicellular LRN, although cells targeting the c2 zone appeared to be more restricted in distribution. In addition to these interzonal differences, it was found that the projection to the pars posterior from cells in the parvicellular LRN was stronger than that to the pars anterior, irrespective of the cortical zone injected. Overall, the present study provides evidence that there is at least some topographical organisation within the LRN mossy fibre projection to certain cerebellar cortical zones.

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The pontocerebellar projection: longitudinal zonal distribution of fibers from discrete regions of the pontine nuclei to vermal and parafloccular cortices in the rat

Cited by 37 publications

References 28 publications

Cerebellar Nitric Oxide Synthase Is Expressed within Granule Cell Patches Innervated by Specific Mossy Fiber Terminals: A Developmental Profile

Cerebellar Nitric Oxide Synthase Is Expressed within Granule Cell Patches Innervated by Specific Mossy Fiber Terminals: A Developmental Profile

Constitutive expression of the 25-kDa heat shock protein Hsp25 reveals novel parasagittal bands of Purkinje cells in the adult mouse cerebellar cortex

Topographical organisation within the lateral reticular nucleus mossy fibre projection to the c1 and c2 zones in the rostral paramedian lobule of the cat cerebellum

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