The porcine intestinal receptor forEscherichia coliK88ab, K88ac: regional localization on chromosome 13 and influence of IgG response to the K88 antigen

Abstract

The loci encoding the porcine intestinal receptors for Escherichia coli K88ab and K88ac (K88abR and K88acR) were firmly assigned to chromosome 13 by linkage analysis using a three-generation pedigree. The linear order of these loci and seven other markers on chromosome 13 was determined by multipoint analyses. The K88abR and K88acR loci were tightly linked (theta = 0.01, zeta = 41.06) with the K88abR locus localized 7.4 cM (sex average) proximal to the transferrin locus. The results, together with previous reports from two other groups, provide an unequivocal assignment of the K88 receptor loci to chromosome 13, and reject a previous assignment to chromosome 4. Pigs possessing the receptor had a slightly higher specific IgG response to the K88 antigen after an intramuscular immunization with an E. coli vaccine.

Differential immunity in pigs with high and low responses to porcine reproductive and respiratory syndrome virus infection1,2

“…Incidence of pigs in disease classifications and distributions of leukocytes in serum of pigs are low to moderately heritable (Henryon et al, 2001(Henryon et al, , 2002. Genetic variation in response to modulation of the immune system also has been demonstrated (Edfors-Lilja et al., 1995;Mallard et al, 1998;Wilkie and Mallard, 1999).…”

Utilizing stochastic genetic epidemiological models to quantify the impact of selection for resistance to infectious diseases in domestic livestock.

“…trait loci influencing disease resistance have been demonstrated (Belt et al, 1995;Edfors-Lilja et al, 1995). Genetic selection for resistance to infectious diseases, although possible, may be difficult and costly.…”

A second-generation linkage map of the bovine genome.

“…Average marker interval exceeds 5 cM in pigs and 10 cM in cattle, sheep, and goats. These maps have been used to identify loci in cattle [horn development (Georges et al 1993a), weaver disease (Georges et al 1993b), milk production (Georges et al 1995), roan coat color (Charlier et al 1996), muscle hypertrophy (Charlier et al 1995)]; sheep [fecundity (Montgomery et al 1994) and muscle hypertrophy (Cockett et al 1994)]; and pigs [fat and growth traits ) and disease resistance (Edfors-Lilja et al 1995)]. Most of these loci have been mapped to >10-cM intervals or they extend beyond the end of the linkage group.…”