The Porcine Model for Intratemporal Facial Nerve Trauma Studies

Barrs, David M.; Trahan, Creighton J.; Casey, Kenneth L.; Brooks, Daniel I.

doi:10.1177/019459989110500613

Cited by 12 publications

(15 citation statements)

References 13 publications

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“…The Callithrix sp is promising in the application of these study models since surgically we have been able to locate the same anatomical structures mentioned in these papers [1][2][3][4][5][6][7][8][9][10] . However, some details must be stressed.…”

Section: Discussionmentioning

confidence: 99%

“…Small size mammals such as rats, mice and guinea pigs [1][2][3][4][5] are commonly used in studies of temporal bones, and their anatomy and physiology are broadly described. Other mammals such as racoons 6 and pigs 7 are also well defined experimental models. However, the phylogenetic distance of such animals to human beings does not allow direct inference of the results obtained 8 .…”

Section: Introductionmentioning

confidence: 99%

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Estudo anatômico do osso temporal de um primata não-humano (Callithrix sp)

Borin

Covolan

Mello

et al. 2008

Rev. Bras. Otorrinolaringol.

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The search for experimental (animal) models is essential to the development of clinical studies. Aim: To demonstrate, by means of micro dissection techniques, the anatomical structures of temporal bones from the primate Callithrix sp. Study design: Experimental. Methods: Dissection of temporal bone structures of Callithrix sp and photographic documentation. Results: We identified the main constituents of the temporal bone (external, medium and inner ear and facial nerve). Conclusion: The non-human primate Callithrix sp. is an adequate experimental model for the studies of temporal bone structures given its close anatomical similarities to that found in humans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Estudo anatômico do osso temporal de um primata não-humano (Callithrix sp)

Borin

Covolan

Mello

et al. 2008

Rev. Bras. Otorrinolaringol.

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show abstract

“…30 All have been well documented in the literature; however, cadaveric dissection always appears to set the standard against which other methods must compare in order to gain general acceptance as valid training alternatives to live surgery.…”

Section: Alternatives To Cadaveric Dissectionmentioning

confidence: 99%

Review of temporal bone dissection teaching: how it was, is and will be

2009

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Objective: We aimed to review the history of anatomical dissection, and to examine how modern educational techniques will change the way temporal bone dissection is taught to otolaryngology trainees.Method: Review of the literature using Medline, Embase and PubMed database searches. Results: Temporal bone anatomy has traditionally been taught using cadaveric specimens. However, resources such as three-dimensional reconstructed models and 'virtual reality' temporal bone simulators have a place in educating the otolaryngology trainee.Conclusion: We should encourage the use of fresh frozen cadaveric temporal bone specimens for future otologists. Artificial three-dimensional models and virtual reality temporal bone simulators can be used to educate junior trainees, thus conserving the scarce resource of cadaveric bones.

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“…In the present study, the effects of the collagen/β‐TCP conduit was evaluated by utilizing the facial nerve gap of a mini‐swine model, which may represent a relatively actual situation in most human nerve injuries, and be an optimal model for studying facial nerve injury …”

Section: Discussionmentioning

confidence: 99%

Collagen/β‐TCP nerve guidance conduits promote facial nerve regeneration in mini‐swine and the underlying biological mechanism: A pilot in vivo study

Zhang

et al. 2018

J Biomed Mater Res

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This study aimed to evaluate the efficiency of new nerve guidance conduits (NGCs) in bridging facial nerve gaps, and investigate the underlying biological mechanisms implicated in the regeneration process. A collagen/β-TCP conduit was prepared and applied to a facial nerve gap in a mini-swine model. Functional recovery and axonal regeneration were further evaluated by electrophysiological and histological examinations at 3 months after surgery. Furthermore, the global transcriptomic profiles of regenerated and normal tissues were analyzed by gene microarray to identify the differentially expressed genes at day three and seven, postoperatively. Subsequently, associated biological processes were analyzed by gene ontology (GO) enrichment analysis. The electrophysiological examination and morphological analysis revealed that significant nerve regeneration effects were achieved in the Col/β-TCP group (p < 0.05). Transcriptional analysis revealed that at day three post-surgery, the majority of overexpressed genes were associated with inflammatory, immune and stimuli response, accompanied by angiogenesis, while at day seven, the majority of overexpressed genes were associated with cell, tissue and organ regeneration and development, synaptic transmission, neurogenesis, and neuronal differentiation, as well as the WNT, MAPK/ERK, and JAK/STAT signaling pathways. In conclusion, the present results suggest that collagen/ β-TCP NGCs provide a promising tubular micro-environment for nerve regeneration.

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The Porcine Model for Intratemporal Facial Nerve Trauma Studies

Cited by 12 publications

References 13 publications

Estudo anatômico do osso temporal de um primata não-humano (Callithrix sp)

Estudo anatômico do osso temporal de um primata não-humano (Callithrix sp)

Review of temporal bone dissection teaching: how it was, is and will be

Collagen/β‐TCP nerve guidance conduits promote facial nerve regeneration in mini‐swine and the underlying biological mechanism: A pilot in vivo study

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